Toxicological evaluation of acute and sub-chronic ingestion of hydroalcoholic extract of Solanum cernuum Vell. in mice

Almança, Carlos Cesar Jorden; Saldanha, Samara V.; Sousa, Dyeime Ribeiro de; Trivilin, Leonardo Oliveira; Nunes, Lélia Cápua; Porfírio, Lenir Cardoso; Marinho, Bruno Guimarães

doi:10.1016/j.jep.2011.09.045

Cited by 34 publications

(26 citation statements)

References 14 publications

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“…Normal food and water consumption of animals clearly support the gain in body of animals throughout the study period. Hematopoietic system is the most sensitive target for toxic substances and it is the important index of physiological and pathological status 8,9 and hence hematological investigation was carried out. No abnormality was observed in hematopoietic function indices for AECH treated groups compared with control groups indicating the extract is safe.…”

Section: Discussionmentioning

confidence: 99%

Acute and sub-acute Toxicity study of Aqueous extracts of Canscora heteroclita (L) Gilg in Rodents

Rajasekaran¹,

Arivukkarasu²

2016

Phcogj

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Background: Canscora heteroclita (C. heteroclita) being used in the Ayurvedic system of medicine in India for the treatment of various diseases. No systematic toxicity study for this plant was described. Objective: The present study was undertaken to assess the safe use of this plant in traditional practice. Materials and Methods: The acute oral toxicity study of aqueous extract of Canscora heteroclita (AECH) was carried out as per the OECD guidelines 423 in mice and the sub-acute toxicity was carried out at a dose of 200 mg/kg and 400 mg/kg as per OECD 407 guidelines in male and female rats. Results: Mice administered upto 2000 mg/kg as a single dose orally not caused any signs of toxicity or mortality in mice. In sub-acute toxicity study in rats, AECH at two different daily doses of 200 and 400 mg/kg for 28 days did not cause any significant change including the hematological and biochemical parameters. Histopathological examinations showed normal architecture suggesting no morphological disturbances.

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Section: Discussionmentioning

confidence: 99%

Acute and sub-acute Toxicity study of Aqueous extracts of Canscora heteroclita (L) Gilg in Rodents

Rajasekaran¹,

Arivukkarasu²

2016

Phcogj

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“…Its folk name, ‘panaceia’, suggests that it can be used to treat many diseases, such as gastric ulcer, liver damage, skin infections, gonorrhea, as well as antitumor, anti‐arrhythmic agents. These uses have been reported for the aerial parts of S. cernuum …”

Section: Introductionmentioning

confidence: 77%

Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

Miranda

Mondal

Singh

et al. 2019

Chemistry & Biodiversity

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Cernumidine (CER) is a guanidinic alkaloid isolated from Solanum cernuum leaves. In this work, we investigated the cytotoxicity, chemosensitizing effect of cernumidine to cisplatin (cDDP) and the possible mechanism of action of the combination on bladder cancer cells. Cernumidine showed cytotoxicity and could sensitize bladder cancer cells to cisplatin. The combination of CER+cDDP inhibited cell migration on T24 cells. CER+cDDP down‐regulated MMP‐2/9 and p‐ERK1/2, while it increased EGFR activity corroborating the observed cell migration inhibition. Down‐regulation of Bcl‐2 and up‐regulation pro‐apoptotic Bax and further depletion of the mitochondrial membrane potential (ΔΨm) indicates that mitochondria play a central role in the combination treatment inducing the mitochondrial signaling pathway of apoptosis in T24 cells. Our data showed that the alkaloid cernumidine is worthy of further studies as a chemosensitizing agent to be used in complementary chemotherapy.

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“…Normal food and water consumption of animals clearly support the gain in body of animals throughout the study period. Hematopoietic system is the most sensitive target for toxic substances and it is the important index of physiological and pathological status [20][21] and hence hematological investigation was carried out. No abnormality was observed in hematopoietic function indices for AEEA treated groups compared with control groups indicating the extract is safe.…”

Section: Discussionmentioning

confidence: 99%

Acute and Sub-acute Toxicity Study of Aqueous Extracts of Enicostemma axillare (Lam.) Raynal in Animal models

Rajasekaran¹,

Arivukkarasu²

2015

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Background: Enicostemma axillare (Lam.) Raynal is used in traditional practice for the treatment of diabetes, malaria and liver disorders. No systematic toxicity study was described for this plant and hence the present was undertaken to evaluate acute and sub-acute toxicity of aqueous extract of Enicostemma axillare (AEEA). Objective: The acute oral toxicity study of AEEA was carried out as per the OECD guidelines 423 in mice and the sub-acute toxicity was carried out as per the guidelines set by OECD 407 in male and female rats. Materials and Methods: Body weight, food and water consumption, hematological parameters, biochemical parameters, organ weight and histopathological analysis were carried out. Results: No gross toxicity and mortality was observed upto a dose of 2000 mg/kg. For sub-acute toxicity test, 200 mg/kg and 400 mg/kg daily dose of AEEA administered orally for 28 days in male and female group of rats not exhibited any signs of toxicity and mortality.

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Toxicological evaluation of acute and sub-chronic ingestion of hydroalcoholic extract of Solanum cernuum Vell. in mice

Cited by 34 publications

References 14 publications

Acute and sub-acute Toxicity study of Aqueous extracts of Canscora heteroclita (L) Gilg in Rodents

Acute and sub-acute Toxicity study of Aqueous extracts of Canscora heteroclita (L) Gilg in Rodents

Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

Acute and Sub-acute Toxicity Study of Aqueous Extracts of Enicostemma axillare (Lam.) Raynal in Animal models

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