Toxicological evaluation of clay minerals and derived nanocomposites: A review

Maisanaba, Sara; Pichardo, Silvia; Puerto, María; Gutiérrez-Praena, Daniel; Cameán, Ana M.; Jos, Ángeles

doi:10.1016/j.envres.2014.12.024

Cited by 194 publications

(140 citation statements)

References 152 publications

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“…This might further substantiate the results of WST-1 assay where only 1000 g/mL concentration was found to exert cytotoxicity. While discussing the prospects of halloysite nanotubes two things must be kept in mind, the first being the fact that other nanoclay materials are known to exhibit lower toxicity in-vivo as compared to in-vitro results [14]. Secondly, for various conventional dosage forms especially tablets, the diluents are used in the range of minimum 20% for tablets having large dose sizes (∼400-500 mg) to maximum 90% in tablets having low dose sizes (≤25 mg), respectively [39].…”

Section: Resultsmentioning

confidence: 99%

“…So far few studies have tried to explore its cytotoxicity with some promising results through mostly random in-vitro studies against some cancer cell lines for e.g., HeLa, MCF-7, NIH-3T3, and A549 etc. [12][13][14][15][16]. A very recent in-vivo toxicity study in a soil nematode Caenorhabditis elegans has also demonstrated high safety prospects of this novel clay even at high concentration of 1000 g/mL [17].…”

Section: Introductionmentioning

confidence: 92%

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In-vitro assessment of cytotoxicity of halloysite nanotubes against HepG2, HCT116 and human peripheral blood lymphocytes

Ahmed

Shoaib

Azhar

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

In-vitro assessment of cytotoxicity of halloysite nanotubes against HepG2, HCT116 and human peripheral blood lymphocytes

Ahmed

Shoaib

Azhar

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Besides the great potential of organic-inorganic combinations, data from toxicological studies are highly conflicting and pertain mostly to in vitro models (104). These results indicate that further studies with a technological emphasis should be carried out in this segment, since no correlation exists between the volume of articles published and number of patents lodged.…”

Section: Technological Prospectionmentioning

confidence: 90%

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Meirelles

Raffin

2017

J Pharm Pharm Sci

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-There has been a growing trend in recent years for the development of hybrid materials, called composites, based on clay and polymers, whose innovative properties render them attractive for drug release. The objective of this manuscript was to conduct a review of original articles on this topic published over the last decade and of the body of patents related to these carriers. A scientific prospection was carried out spanning the period from 2005 to 2015 on the Web of Science database. The technological prospection encompassed the United States Patent and Trademark Office, the European Patent Office, the World International Patent Office and the National Institute of Industrial Property databases, filtering patents with the code A61K. The survey revealed a rise in the number of publications over the past decade, confirming the potential of these hybrids for use in pharmaceutical technology. Through interaction between polymer and clay, the mechanical and thermal properties of composites are enhanced, promoting stable, controlled drugs release in biological media. The most cited clays analyzed in the articles was montmorillonite, owing to its high surface area and capacity for ion exchange. The polymeric part is commonly obtained by copolymerization, particularly using acrylate derivatives. The hybrid materials are obtained mainly in particulate form on a nanometric scale, attaining a modified release profile often sensitive to stimuli in the media. A low number of patents related to the topic were found. The World International Patent Office had the highest number of lodged patents, while Japan was the country which published the most patents. A need to broaden the application of this technology to include more therapeutic classes was identified. Moreover, the absence of regulation of nanomaterials might explain the disparity between scientific and technological output.

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“…Moreover, Cooper and Sargent (1986) indicated that perlite dust does not pose a significant health risk for workers. However, more recent studies, such as those conducted by Maisanaba et al (2015); Maxim et al (2014); Sampatakakis et al (2013), suggest that excess of exposure to perlite dust without the necessary protective equipment might result in adverse health effects. In addition, they indicate that the potential impact of the other minerals that are present in the perlite ore should not be underestimated.…”

Section: Environmental Risks Associated With Perlite Oresmentioning

confidence: 99%

Infrared detection of ore variability that influences the environmental risks during perlite mining and processing

Guatame-Garcia

Buxton

2017

Environ Earth Sci

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In the mining of perlite deposits, controlling the generation of fine particles and the concentration of metals is of outstanding importance to meet the environmental and market requirements. Particle size and chemical purity are conventionally manipulated during the processing of the ore to achieve high product specifications. However, the current practices do not consider a proactive approach that focuses in the in-pit characterisation of the ore that would minimise the environmental impact and optimise the mining process since its early stages. This paper presents a method for the in-pit detection of the perlite ore variability that is related to the generation of fine particles and the elevated concentration of metals. Particle size and chemical purity showed to be dependent on the mineralogical variations of the ore, specifically opal and montmorillonite. Using a portable infrared spectrometer, an index that establishes the relative proportions of these minerals in the perlite ore was created. Such index provided insight into the correlation between mineralogy, fine particles and concentration of metals. Consequently, the index could be used not only for mineralogical determination but also as a predictor of the presence of the main impurities in the perlite ore. These results can be implemented in perlite mining to reduce the generation of waste and can influence the production of high-quality perlite products.

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Toxicological evaluation of clay minerals and derived nanocomposites: A review

Cited by 194 publications

References 152 publications

In-vitro assessment of cytotoxicity of halloysite nanotubes against HepG2, HCT116 and human peripheral blood lymphocytes

In-vitro assessment of cytotoxicity of halloysite nanotubes against HepG2, HCT116 and human peripheral blood lymphocytes

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Infrared detection of ore variability that influences the environmental risks during perlite mining and processing

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