Toxicological evaluation of hydrochlorofluorocarbon 142b

Seckar, J.A.; Trochimowicz, Henry J.; Hogan, G.K.

doi:10.1016/0278-6915(86)90234-6

Cited by 13 publications

(11 citation statements)

References 10 publications

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“…is mutagenic in the Ames test with S. typhimurium TA1535 or TA100 as the test organisms (35) and in a BHK21 cell-transformation assay (34,35). Rats exposed to HCFC-142b by inhalation (100, 10,000, or 20,000 ppm for 6 hr/day, 5 days/week for 13 or 15 weeks) did not show compound-related effects in a bone marrow cytogenetic assay or in a dominant lethal assay (61). No treatment-related effects were observed in a 90-day study of rats and dogs exposed by inhalation to HCFC-142b (1,000 or 10,000 ppm for 6 hr/day, 5 days/week for 90 days) (62) or in a 104-week study ofrats exposed by inhalation to HCFC-142b (1,000, 10,000, or 20,000 ppm for 6 hr/day, 5 days/week for 104 weeks) (61).…”

Section: Metabolism and Toxicity Of Hcfcs Principles Of Metabolism Ofmentioning

confidence: 99%

Metabolism and Toxicity of Hydrochlorofluorocarbons: Current Knowledge and Needs for the Future

Anders¹

1991

Environmental Health Perspectives

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Hydrochlorofluorocarbons (HCFCs) are being developed as replacements for chlorofluorocarbons (CFCs) that deplete stratospheric ozone. The depletion of stratospheric ozone may increase the intensity of ultrviolet radiation at the earth's surface, which may be assodated with global, adverse human health effects. The greater tropospheric lability of HCFCs, which is due to the presence ofC-H bonds, reduces HCFC migration to the stratosphere; HCFCs should, therefore, cause less depletion of stratospheric ozone than CFCs. HCFCs under development include HCFC-22 (chlorodifluoromethane), HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane), HCFC-132b (1,2-dichloro-1,1-difluoroethane), HCFC-134a (1,1,1,2-tetrafluoroethane), HCFC-141b (1,-dich l-fluoroethane, and HCFC-142b (1-chloro-1,1-duoroethane). With the exception ofHCFC-22, which is already in use, the metabolism and toxicity ofHCFCs have not been studied in detail. By analogy to chlorinated ethanes, predictions can be made about the possible metabbolism ofHCFCs, but there are insufficient data available to predict rates of metabolism. Although most HCFCs appear to show low acute toxicity, some HCFCs are mutagenic in the Ames test. Hence, future researh on HCFCs should include studies on the in vivo and in vibo metabolism of HCFCs as well as on their toxicity in in ivo and in vitro systems.

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Section: Metabolism and Toxicity Of Hcfcs Principles Of Metabolism Ofmentioning

confidence: 99%

Metabolism and Toxicity of Hydrochlorofluorocarbons: Current Knowledge and Needs for the Future

Anders¹

1991

Environmental Health Perspectives

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“…A cell transformation test with BALB/3T3 cells produced negative results [14], another cell transformation test with BHK21 cells ("Styles test") was (weakly) positive [13].…”

Section: Mutagenicity and Carcinogenicitymentioning

confidence: 99%

“…The results of the subsequent cytogenetic investigation of bone marrow cells were considered to be negative [14]. A dominant lethal test was carried out on another set of groups of 10 male animals which had been exposed for 15 weeks, again under the same conditions.…”

Section: Mutagenicity and Carcinogenicitymentioning

confidence: 99%

“…Since the results of these short-term tests raised the question of a carcinogenic potential of 1-chloro-1,1-difluoroethane, a long-term inhalation study was carried out with groups of 110 male and female Sprague-Dawley-derived CD rats [14]. The animals inhaled concentrations of 0 (controls), 1000, 10000 or 20000 ml 1-chloro-1,1-difluoroethane/m 3 , 6 hours per day, 5 days per week for 104 weeks.…”

Section: Mutagenicity and Carcinogenicitymentioning

confidence: 99%

“…With the exception of a single anomalous result caused by two animals in one group (mated after 7 weeks), no statistically significant accumulation of dead implants occurred in the experiments with animals given 1-chloro-1,1-difluoroethane. The results of the dominant lethal test were considered to be negative [14].…”

Section: Mutagenicity and Carcinogenicitymentioning

confidence: 99%

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1‐Chloro‐1,1‐difluoroethane [MAK Value Documentation, 1990]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 1 (1990) The article contains sections titled: Toxic Effects and Modes of Action Effects in Man Effects on Animals Mutagenicity and Carcinogenicity Manifesto (classification/MAK value)

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Organic Chlorofluoro Hydrocarbons

Gadagbui,

Onyema

2023

Patty's Toxicology

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This chapter is about organic chlorofluoro hydrocarbons, which are fully or partly halogenated hydrocarbons that contain carbon (C), hydrogen (H), chlorine (Cl), and fluorine (F). In the early 1930s, chlorofluorocarbons (CFCs) were introduced in the 1930s as “safe” replacements for refrigerants such as sulfur dioxide, ammonia, carbon tetrachloride, and chloroform. The list was later expanded during World War II to include their use to produce insecticide aerosols to protect the troops in tropical areas against malaria and other insect‐borne diseases. Current usages include foam blowing, precision cleaning, and propellants for medicinal, cosmetic, and general‐purpose aerosols, air conditioning, and refrigeration. The expanded use of these CFCs has resulted in their emissions into the atmosphere. The CFCs have low chemical reactivity, long atmospheric lifetime, and are globally distributed. However, since they are ozone‐depleting and are also powerful greenhouse gases (GHGs), development was initiated to replace them with comparatively less ozone‐depleting and less greenhouse‐warming hydrochlorofluorocarbons (HCFCs). Subsequently, hydrofluorocarbons (HFCs) were developed that were both less ozone‐depleting and less GHGs accumulating. Both CFCs and HCFCs are controlled under the Montreal Protocol. The widespread use concerns about their environmental and human health effects of these substances have been extensively reviewed. This chapter updates information on the health effects of some of the major and minor CFCs, HCFCs, and HFCs, their global emissions estimates, the discrepancies, if any, between the major reporting regions and the global atmospheric emissions values, and the likely sources of the gap between the atmospheric measurements and the reported emissions.

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Toxicological evaluation of hydrochlorofluorocarbon 142b

Cited by 13 publications

References 10 publications

Metabolism and Toxicity of Hydrochlorofluorocarbons: Current Knowledge and Needs for the Future

Metabolism and Toxicity of Hydrochlorofluorocarbons: Current Knowledge and Needs for the Future

1‐Chloro‐1,1‐difluoroethane [MAK Value Documentation, 1990]

Organic Chlorofluoro Hydrocarbons

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