Toxicological evaluation of &lt;em&gt;Thymelaea hirsuta&lt;/em&gt; and protective effect against CCl&lt;sub&gt;4&lt;/sub&gt;-induced hepatic injury in rats

Azza, Zora; Marnissi, F.; Naya, Aziza Ben; Benjelloun, Naima; Zamyati, S; Amrani, M.; Oudghiri, Mounia

doi:10.4314/ijbcs.v6i1.33

Cited by 9 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Measurement of these enzymes is significant in clinical and toxicological studies as changes in their activities are indicative of tissue damage by toxicants. The increase in serum level of these enzymes might be due to their leakage out of the tissues into the blood system due to destruction of their cellular membranes (Azza et al, 2012). Exposure to chemical compounds may result into significant changes in the structure, function, metabolic transformation and concentration of biomolecules, enzymes and even metabolic pathways.…”

Section: Discussionmentioning

confidence: 99%

Changes in activities of tissues enzymes in rats administered <i>Ficus exasperata</i> leaf extract

Oyewole¹,

Oladele²

2017

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

This study evaluates the effects of methanolic extract of Ficus exasperata leaf on the activities of some enzymes in the serum, liver, kidney and heart of albino rats. Twenty four rats were sorted into four groups: Group A (control) received distilled water while rats in groups B, C and D were administered graded doses (100, 200 and 500 mg/kg bw) of methanolic leaf extract of Ficus exasperata respectively for 14 days. Activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and acid phosphatase (ACP) were determined in the serum and tissues. Results obtained showed that administration of graded doses of Ficus exasperata leaf extract to rats caused significant increase (p<0.05) in growth rate compared to the control. Rats administered 500 mg/kg bw of the extract recorded significant decrease in tissues levels of the enzymes accompanied with their elevation in the serum indicating toxicity at this dose. There was also a significant increase in relative organ weight in rats who received 500 mg/kg bw of the extract. Rats administered low and moderate doses (100 and 200 mg/kg bw) of the extract showed no significant alteration in enzyme activities in the serum and tissues as well as relative organ weight. The results suggest that intake of leaf extract of Ficus exasperata as a medicinal remedy is safe at lower dose and could help to promote growth. The extract might however be toxic to the organs when taken at high doses.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in activities of tissues enzymes in rats administered <i>Ficus exasperata</i> leaf extract

Oyewole¹,

Oladele²

2017

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

show abstract

“…The aqueous extract was screened for alkaloids, flavonoids, tannins, and saponins as described before 14,15 . Tests were based on the visual observation of color changes or formation of a precipitate after the addition of specific reagents.…”

Section: Preliminary Phytochemical Screeningmentioning

confidence: 99%

Untitled

2019

IJPSR

View full text Add to dashboard Cite

Euphorbia resinifera Berg. (ER) an endemic Moroccan plant has been used to treat different diseases. In spite of its toxicological potential, no scientific report until now was made to evaluate in-vivo neither the toxic effect nor its immunomodulatory activity. The objective was to evaluate the safety of an aqueous extract (AE) of ER in-vivo and its effect on the biochemical, immunological and histopathological parameters. The AE was administrated in single oral dose (5g/kgbw) for the acute toxicity tests given daily by gavages at 0.1, 0.5, 1, 2.5, or 5 g/kg for 28 consecutive days. Serum was analyzed for creatinine, urea, alanine aminotransferase, and aspartate aminotransferase. Histopathological examination of liver, kidneys, and spleen was done at the end of the study. The immunological effect was tested by the evaluation of antibodies production and the level of the delayed type hypersensitivity reaction. No signs of toxicity or deaths were observed in mice treated by a single dose. In the sub-acute toxicity tests, no visible toxic effects were observed at 0.1-1 g/kg doses. However, at 2.5 and 5 g/kg doses, the mice showed some behavioral signs of toxicity. This was confirmed by the histological and biochemical evaluations. When tested against SRBC, there was a significant increase of "haemagglutinating antibody titer" and in "delayed-type hypersensitivity" response in mice treated by ER at 1 g/kg bw (4 and 1.5 times respectively p<0.05). Higher than 2.5 g/kg, the ER can cause liver and kidney toxicity. The immune-stimulatory effect was induced by an inflammatory reaction. QUICK RESPONSE CODE

show abstract

“…(Quezel et Santa 1963). Previous studies showed that T. hirsuta has no toxic effects on humans (Bnouham et al 2007;Azza et al 2012). Various parts of T. hirsuta have been widely used in the paper industry (Schmidt et al 1983).…”

Section: Introductionmentioning

confidence: 99%

“…In traditional medicine, T .hirsuta is used as antiseptic, anti-inflammatory and in the treatment of hypertension (Le Floc'h 1983;Azza et al 2012;Bnouham et al 2012;Azza and Oudghiri 2015). It is also used in hypoglycemic, antidiabetic drugs and as an antioxidant (Ziyyat et al 1997;Djeridane et al 2006;El Amrani et al 2009;Akrout et al 2011;Trigui et al 2013;Yahyaoui et al 2017, 2018a and.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and antibacterial activity of essential oils of Thymelaea hirsuta from Algeria

et al. 2019

View full text Add to dashboard Cite

Abstract. Souhila B, Takia L, Messaoud R, Pierre C, Gilles F. 2019. Chemical composition and antibacterial activity of essential oils of Thymelaea hirsuta from Algeria. Biodiversitas 20: 2868-2876. The objectives of this study were to determine the chemical composition and to evaluate the antibacterial activity of Thymelaea hirsuta (L.) Endl., essential oils from seven sampling locations in M'sila region (Algeria). Extraction of essential oils was carried out by the hydro-distillation; the analysis of chemical composition of essential oil was carried out by GC-MS. Antimicrobial activity was performed by disc diffusion method at the essential oil concentration of non-diluted and diluted (1:2, 1:4 and 1:8 v:v of DMSO) against eight species of bacteria. The results showed that the average yields of essential oils were 0.3 ± 0.12%. A total of 45 components were identified, averaging 98.2 ± 1.85% of the total oils. The main components were nonanal-n (10.39 ± 3.21%), hexadecanoic acid (9.77 ± 2.81%), nonanoic acid (9.13 ± 6.49%), triacontane (7.2 ± 3.34%), isopropyl tetradecanoate (6.16 ± 1.99%) and tridecane (4.87 ± 3.1%). Based on the UPGMA cluster analysis, there were two clades of T. hirsuta. T. hirusta has a chemical polymorphism with different chemotypes marked in nature. There were four chemotypes identified in the essential oil of T. hirsuta in the region of M'sila. The essential oil of T. hirsuta has antibacterial activity against eight tested bacteria on the concentration-dependentt manner.

show abstract

Toxicological evaluation of <em>Thymelaea hirsuta</em> and protective effect against CCl<sub>4</sub>-induced hepatic injury in rats

Cited by 9 publications

References 14 publications

Changes in activities of tissues enzymes in rats administered <i>Ficus exasperata</i> leaf extract

Changes in activities of tissues enzymes in rats administered <i>Ficus exasperata</i> leaf extract

Untitled

Chemical composition and antibacterial activity of essential oils of Thymelaea hirsuta from Algeria

Contact Info

Product

Resources

About