Toxicological safety evaluation in acute and 28-day studies of aqueous extract from Serjania marginata Casar. (Sapindaceae) leaves in rats

Moreira, Suyane da Silva; Tamashiro, Letícia Kaory; Jorge, Bárbara Campos; Balin, Paola da Silva; Vieira, Silvia Cristina Heredia; Almeida, Gabriela L.; Cardoso, Cláudia Andréa Lima; Kassuya, Cândida Aparecida Leite; Arena, Arielle Cristina

doi:10.1016/j.jep.2018.11.024

Cited by 19 publications

(10 citation statements)

References 29 publications

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“…O efeito de antixenose causado pelas espécies S. erecta e S. marginata foi observado em todos os tratamentos, independentemente do método (sem chance e com chance) utilizado, podendo ser decorrente da presença de compostos bioativos oriundos dos metabólitos secundários destas espécies vegetais (Guimarães et al, 2015;Moreira et al, 2019).…”

Section: Discussionunclassified

“…Dentre as famílias vegetais, a Sapindaceae é investigada em alguns estudos apresentando espécies com potencial ação inseticida (Couto et al, 2019;Ramírez-Zamora et al, 2020). Os compostos mais abundantes encontrados nessa família são os compostos fenólicos, flavonoides, esteroides, taninos, saponinas e antraquinonas, que podem apresentar ação inseticida para determinados insetos (Quintanilla et al, 2014;Guimarães et al, 2015;Moreira et al, 2019Salinas-Sánchez et al, 2020.…”

Section: Introductionunclassified

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Efeito de extratos aquosos de Serjania spp. sobre a oviposição de Plutella xylostella L. (Lepidoptera: Plutellidae)

Faca

Ferreira

Silva

et al. 2021

RSD

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A bioprospecção de espécies vegetais para o desenvolvimento de bioinsetidas pode contribuir para o controle de populações de Plutella xylostella na cultura das brássicas. O objetivo desta pesquisa foi estudar o efeito dos extratos aquosos de Serjania erecta e Serjania marginata, nas concentrações 5 e 10%, sobre a oviposição de P. xylostella. Para isso, foram realizados dois testes: o primeiro consistiu em um teste sem chance de escolha, onde foi colocado em cada gaiola um disco de couve tratado e um casal de adultos de P. xylostella; o segundo consistiu em um teste com chance de escolha, onde foram colocados em cada gaiola quatro discos tratados (dois discos tratados com extrato vegetal e dois discos tratados com água destilada) e um casal de adultos de P. xylostella. O experimento de oviposição sem chance de escolha foi realizado em delineamento experimental inteiramente casualizado (DIC) em esquema fatorial duplo (3x2) com 15 repetições por tratamento e o experimento com chance de escolha em delineamento experimental inteiramente casualizado (DIC). Foram contabilizados, diariamente, o número de ovos (fecundidade) e o número de larvas recém-emergidas (fertilidade dos ovos) durante 10 dias e calculado a viabilidade dos ovos (%) e o Índice de Dissuasão de Oviposição (IDO). Os resultados indicaram o efeito dissuasor das duas espécies vegetais, com redução da fecundidade, fertilidade e viabilidade de ovos nos tratamentos com os extratos aquosos de S. erecta e S. marginata, nas concentrações 5% e 10%, sendo que a concentração 10% apresentou melhores resultados para o teste sem chance de escolha. Portanto, as duas espécies vegetais apresentaram ação inseticida, atuando na redução da fecundidade, fertilidade, viabilidade de ovos e na dissuasão de oviposição deste microlepidóptero, contribuindo para o seu controle em cultivos de hortaliças.

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Section: Discussionunclassified

Section: Introductionunclassified

Efeito de extratos aquosos de Serjania spp. sobre a oviposição de Plutella xylostella L. (Lepidoptera: Plutellidae)

Faca

Ferreira

Silva

et al. 2021

RSD

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“…Périco and colleagues (2015) also showed that hydroalcoholic extract from leaves of S. marginata was antimicrobial, antidiarrheal, and (anti)mutagenic. Moreira et al (2019) demonstrated that S. marginata leaves aqueous extract was not toxic after a single exposure, however if it was used after prolonged periods it affected some parameters. Périco et al (2015) showed that after 14 days of administration hydroalcoholic extract also affected some parameters such as induce gastric lesions.…”

Section: Introductionmentioning

confidence: 99%

Serjania marginata Casar. hydroalcoholic extract reduced cytokine and inflammatory parameters in experimental models of inflammation and infection in mice

Leitão¹,

Radai²,

Macorini³

et al. 2021

Preprint

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This study investigated the antimycobacterial, anti-inflammatory and antihyperalgesic effects of EESM in in vitro and in vivo models. EESM (0.98–1000 µg/ml) was evaluated in in vitro against Mycobacterium tuberculosis, M. bovis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus epidermidis. The EESM oral administration (p.o.) (30, 100 and 300 mg/kg) and dexamethasone subcutaneous injection (s.c.) (1 mg/kg) were tested against the carrageenan-induced inflammatory paw edema and pleurisy in Swiss mice. The EESM (30 and 100 mg/kg, p.o.) and dexamethasone (1 mg/kg, s.c.) were tested against the CFA-induced paw inflammation and M. bovis (bacillus Calmette-Guerin - BCG)-induced pleurisy in C57bL6 mice. The minimum inhibitory concentration (MIC) of EESM in the presence of M. tuberculosis was 62.4 µg/ml. The values of MIC of EESM in the presence S. epidermidis, K. pneumoniae were 1000 µg/mL while EESM did not interfere with against P. aeruginosa growth. EESM significantly inhibited paw edema/mechanical hyperalgesia in carrageenan induced paw inflammation and leukocytes migration/proteins exudation in carrageenan-induced pleurisy model. In the BCG-induced pleurisy model, the daily treatment for 7 days, with EESM inhibited the levels of IL-1β in blood and in pleural exudate. The EESM did not alter the mycobacterial growth in the cell culture from pleural lavage, spleen and liver samples collected from BCG-treated animals. The EESM significantly inhibited the persistent edema and mechanical hyperalgesia induced by CFA. This study confirms the EESM anti-inflammatory property and showed that EESM has high potency in inducing inhibition of mycobaterial growth and low potency or no effects in relation to other microorganisms.

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“…17 However, despite these beneficial effects, daily administration of the SM hydroalcoholic extract aggravates gastric injuries, 16 and the use of the SM aqueous extract for extended periods alters kidney histology and increases abnormal sperm production in rats. 18 These results suggest the need for further experiments to evaluate possible hazard effects (i.e., cytotoxicity and mutagenicity) of the SM extract. and the proanthocyanidins A-1 and A-2, as well as cinnamtannin B-1.…”

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confidence: 99%

“…17 In the SM aqueous extract, the major compounds identified were quinic acid, the glycosylated flavonoids quercitrin and isoquercitrin, and A-type proanthocyanidin trimer. 18 Due to the therapeutic importance of SM leaf extract to treat gastrointestinal disorders, the present study investigated whether it affected cell viability and proliferation, expression of genes involved in cell cycle regulation, apoptosis and antioxidant defense, and production of intracellular reactive oxygen species (ROS) in non-tumor gastric epithelium cells (MNP01) and tumor gastric adenocarcinoma cells (ACP02) in vitro. The goal of this study is to contribute to better understanding of the biological activities of Serjania marginata Casar., which are poorly evaluated in the literature, and to contribute to future studies for the treatment of inflammation-, mutagenesis-, and oxidative stress-related gastric diseases.…”

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confidence: 99%

Selective anticancer effects of Serjania marginata Casar. extract in gastric cells are mediated by antioxidant response

Serpeloni

Specian

Ribeiro

et al. 2021

Environmental Toxicology

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Gastric cancer is the fifth most common malignancy worldwide. Serjania marginata Casar. (SM) displays anti-inflammatory properties and has been used to treat gastrointestinal disorders. In the current study, we examined whether the hydroethanolic extract of SM leaves exerted cytotoxic, mutagenic, and protective effects in nontumor gastric epithelium cells (MNP01) and gastric adenocarcinoma cells (ACP02) in vitro and analyzed whether its action was selective. Initially, cell viability (MTT assay), cell cycle kinetics (flow cytometry), and cell proliferation (total protein content) were analyzed. In addition, genomic instability (cytokinesis-block micronucleus cytome assay), anti/pro-oxidant status (CM-H 2 DCFDA probe), and transcriptional expression (RT-qPCR) of genes related to cell cycle, cell death, and antioxidant defense were also evaluated. The SM extract was cytotoxic toward MNP01 and ACP02 cells at concentrations greater than 300 and 100 μgÁml À1 , respectively, and decreased protein content only toward ACP02 cells at 200 μg ml À1 . In ACP02 cells, the SM extract at 100 μgÁml À1 associated with doxorubicin (DXR; 0.2 μg ml À1 ) clearly promoted cell cycle arrest at the G2/M phase. The extract alone was not mutagenic to either cell type and reversed DXR-induced DNA damage and H 2 O 2 -induced oxidative stress in MNP01 cells. The gene expression experiments showed that SM hydroethanolic extract exerts an antioxidant response via NFE2L2 activation in nontumor gastric cells, and cell cycle arrest (G2/M) in ACP02 gastric cancer cells via the TP53 pathway. The selective action of SM indicates that it is a promising therapeutic agent to treat gastric diseases and merits further studies.

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Toxicological safety evaluation in acute and 28-day studies of aqueous extract from Serjania marginata Casar. (Sapindaceae) leaves in rats

Cited by 19 publications

References 29 publications

Efeito de extratos aquosos de Serjania spp. sobre a oviposição de Plutella xylostella L. (Lepidoptera: Plutellidae)

Efeito de extratos aquosos de Serjania spp. sobre a oviposição de Plutella xylostella L. (Lepidoptera: Plutellidae)

Serjania marginata Casar. hydroalcoholic extract reduced cytokine and inflammatory parameters in experimental models of inflammation and infection in mice

Selective anticancer effects of Serjania marginata Casar. extract in gastric cells are mediated by antioxidant response

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