Toxicological safety evaluation of an aqueous lemon balm (Melissa officinalis) extract

Lobach, Alexandra R.; Schmidt, Florian; Fedrizzi, Davide; Müller, Severin

doi:10.1016/j.fct.2024.114565

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Lemon balm is mainly used for its aromatic leaves, which have a lemon-like scent and flavour. The leaves are harvested before or during flowering and can be used fresh or dried as food, food ingredients, food supplements, or medicinal agents [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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NMR Metabolomics of Arctium lappa L., Taraxacum officinale and Melissa officinalis: A Comparison of Spontaneous and Organic Ecotypes

Ambroselli,

Masciulli,

Romano

et al. 2024

Foods

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Officinal plants are a source of metabolites whose chemical composition depends on pedoclimatic conditions. In this study, the NMR-based approach was applied to investigate the impacts of different altitudes and agronomical practices (Land, Mountain Spontaneous, and Organically Grown Ecotypes, namely LSE, MSE, and OE, respectively) on the metabolite profiles of Burdock root, Dandelion root and aerial part, and Lemon balm aerial part. Sugars, amino acids, organic acids, polyphenols, fatty acids, and other metabolites were identified and quantified in all samples. Some metabolites turned out to be tissue-specific markers. Arginine was found in roots, whereas myo-inositol, galactose, glyceroyldigalactose moiety, pheophytin, and chlorophyll were identified in aerial parts. Caftaric and chicoric acids, 3,5 di-caffeoylquinic acid, and chlorogenic and rosmarinic acids were detected in Dandelion, Burdock and Lemon balm, respectively. The metabolite amount changed significantly according to crop, tissue type, and ecotype. All ecotypes of Burdock had the highest contents of amino acids and the lowest contents of organic acids, whereas an opposite trend was observed in Lemon balm. Dandelion parts contained high levels of carbohydrates, except for the MSE aerial part, which showed the highest content of organic acids. The results provided insights into the chemistry of officinal plants, thus supporting nutraceutical–phytopharmaceutical research.

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Section: Introductionmentioning

confidence: 99%

“…The European Medicines Agency (EMA) has evaluated Melissa officinalis L., folium for its use as a medicinal agent and has established a traditional use based on sufficient safety data and plausible efficacy. However, there is a lack of conventional clinical safety data [ 27 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

NMR Metabolomics of Arctium lappa L., Taraxacum officinale and Melissa officinalis: A Comparison of Spontaneous and Organic Ecotypes

Ambroselli,

Masciulli,

Romano

et al. 2024

Foods

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Clinical Efficacy and Tolerability of Lemon Balm (Melissa officinalis L.) in Psychological Well-Being: A Review

Mathews,

Eastwood,

Lamport

et al. 2024

Nutrients

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Background: There is renewed interest in the use of ancient herbal remedies for their potential health benefits, particularly in the psychological domain. One herb that is receiving growing attention is lemon balm (Melissa officinalis L.) which has received considerable interest for its influence on the brain. Lemon balm boasts an array of phytochemicals, including rosmarinic acid, citral, oleanolic acid, and ursolic acid, which are believed to underpin these effects on psychological well-being. Pharmacological evidence from animal and cellular work reveals that lemon balm and its components may modulate several brain signalling pathways, including GABAergic, cholinergic, and serotonergic systems. Results/Conclusions: Although further robust randomised controlled trials using lemon balm are required, existing research indicates that lemon balm holds promise as a calming agent exhibiting both anxiolytic and anti-depressant properties and can elicit cognitive and sleep-quality enhancement.

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Toxicological safety evaluation of an aqueous lemon balm (Melissa officinalis) extract

Cited by 2 publications

References 28 publications

NMR Metabolomics of Arctium lappa L., Taraxacum officinale and Melissa officinalis: A Comparison of Spontaneous and Organic Ecotypes

NMR Metabolomics of Arctium lappa L., Taraxacum officinale and Melissa officinalis: A Comparison of Spontaneous and Organic Ecotypes

Clinical Efficacy and Tolerability of Lemon Balm (Melissa officinalis L.) in Psychological Well-Being: A Review

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