2020
DOI: 10.20527/dentino.v5i1.8132
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Toxicological Screening of Ellagic Acid in Pomegranate Fruit and Hydroxyapatite Combination as Bone Graft Material on BHK-21 Fibroblast Cell

Abstract: Background: Bone graft is an alternative therapy for periodontitis and other bone destructive lesions. Several studies had revealed Ellagic Acid (EA) ability in increasing osteogenesis process. EA contains polyphenols, such as Ellagitannin, Gallotannin, and Anthocyanin, which demonstrate anti-inflammatory and antibacterial activity as well as growth factor stimulating effect. EA combination with bone graft material (hydroxyapatite) is anticipated to enhance bone osteogenesis yet no investigation was performed … Show more

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