2008
DOI: 10.1016/j.toxlet.2008.06.639
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Toxicological studies, membrane transport and pharmacodynamic effect of gliclazide in rats

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“…The presence of the characteristic melting endotherm of GZ in the DSC thermograms of the physical mixtures designates the absence of interaction between the drug and the used polymers. 38 , 39
Figure 3 DSC thermogram for ( A ) gliclazide, ( B ) gelatin, ( C ) chitosan, and ( D ) carbopol.
…”
Section: Resultsmentioning
confidence: 99%
“…The presence of the characteristic melting endotherm of GZ in the DSC thermograms of the physical mixtures designates the absence of interaction between the drug and the used polymers. 38 , 39
Figure 3 DSC thermogram for ( A ) gliclazide, ( B ) gelatin, ( C ) chitosan, and ( D ) carbopol.
…”
Section: Resultsmentioning
confidence: 99%
“…In conformity with in silico studies [49,54], from the results of the study that used Caco-2 cells, it is possible to suggest that gliclazide is a highly permeable drug. Moreover, it indicates that the transcellular passive pathway is the main permeation route of the drug [55]. However, it is worthy to highlight that some studies suggest the influence of efflux transporters, such as MRP2 and MRP3, in the oral absorption of gliclazide [51,60].…”
Section: Permeabilitymentioning
confidence: 99%