Toxicological Studies of the Ayurvedic Medicine “Naradiya Laksmivilasa Rasa” Used in Sinusitis

Hasan, Shemonty; Sikder, Md. Mamun; Ali, Massnoon; Hossain, Mustari; Zulfiquar, Tasniya Nahiyan

doi:10.4172/0974-8369.1000359

Cited by 2 publications

(2 citation statements)

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“…Some substances like alkaloids and heavy metals like mercury, lead, and arsenic may be found in ayurvedic medicines that can be hazardous to the liver and kidney if not properly manufactured, prescribed, or used. [24][25][26][27][28][29] Heavy metals such as mercury in different concentrations is found in all kind of Makaradhwaja formulations and so prolonged use of these medications has a deleterious impact on the liver, kidney, and lipid profile. [30][31][32][33] Previously reported Makardhwaja, which contains sulfur and mercury (24:1), induces considerable elevations in progesterone and luteinizing hormone levels following chronic dosing.…”

Section: Discussionmentioning

confidence: 99%

Steroidal and gonadotropin hormone profile studies of a classical ayurvedic preparation of “Saraguna Balijarita Makardhwaja” after chronic administration to male Sprague-Dawley rats

Kishoara,

Munna,

Mousumi

et al. 2024

Int J Basic Clin Pharmacol

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Background: Saraguna Balijarita Makardhwaja (SGM) is an Ayurvedic preparation used as a traditional antipyretic in the rural population. This research work was designed to get an overview of steroidal and gonadotropin hormone profiles after chronic administration of this drug. Methods: The acute pharmacological test of SGM recorded no death or any signs of effectivity even at the highest dose of 4000 mg/kg body weight. For chronic pharmacological evaluation, sixteen healthy Sprague-Dawley male rats were randomly divided into two groups, one group was a control group and the other was an experimental group. The experimental group was assigned to receive the drug at a dose of 400 mg/kg of body weight orally. After 28 days of treatment, blood samples were collected for biochemical tests. Results: The research showed the following effects on the steroidal and gonadotropin hormone profile. In this study, serum circulating level of dehydroepiandrosterone sulfate (DHEA-S), testosterone level, progesterone, 17-beta-estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured to determine safety profile study of SGM after chronic administration. There were no significant differences in any parameters which is suggesting that SGM has no effect of the steroidal and hormone profile. Conclusions: According to studies, SGM has no harmful effect on the steroid and hormone profiles after chronic treatment. Further studies are needed to establish the safety aspects of SGM.

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Section: Discussionmentioning

confidence: 99%

Steroidal and gonadotropin hormone profile studies of a classical ayurvedic preparation of “Saraguna Balijarita Makardhwaja” after chronic administration to male Sprague-Dawley rats

Kishoara,

Munna,

Mousumi

et al. 2024

Int J Basic Clin Pharmacol

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“…Some herbs, if not used appropriately, can show toxic effects ( Table 1 ). 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 Ayurvedic texts classify herbs according to their safety and potential toxicity. The “Bhavaprakasha Nighantu” and other Ayurvedic pharmacopeias provide information about the toxicity, dosage, and contraindications of various herbs.…”

Section: Toxicological Aspectsmentioning

confidence: 99%

Ayurvedic Medicine: A Traditional Medical System and Its Heavy Metal Poisoning

Sikder

2024

Chonnam Med J

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Ayurveda is one of the oldest and most widely practiced traditional medical systems in the world. The ancient knowledge in this traditional medical system has yet to be fully explored. The interaction of rich knowledge from various traditional systems of medicine can open new pathways in the herbal drug discovery process. Apart from other hurdles in discovering plant-based medicines, the lack of knowledge of the differences and similarities between the theoretical doctrines of these systems is the greatest impediment to their convergence. Rasashastra is an Ayurvedic medicine section that deals with formulations that include minerals/metals, particularly Parad (mercury). According to the Ayurvedic Formulary of India, the most widely used heavy metals are mercury, arsenic, and lead. However, contemporary scientists are concerned about the use of heavy metals in Ayurvedic preparation. In this review article, we will discuss Ayurvedic medicine and the toxic effects of heavy metals.

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Toxicological Studies of the Ayurvedic Medicine “Naradiya Laksmivilasa Rasa” Used in Sinusitis

Cited by 2 publications

References 0 publications

Steroidal and gonadotropin hormone profile studies of a classical ayurvedic preparation of “Saraguna Balijarita Makardhwaja” after chronic administration to male Sprague-Dawley rats

Steroidal and gonadotropin hormone profile studies of a classical ayurvedic preparation of “Saraguna Balijarita Makardhwaja” after chronic administration to male Sprague-Dawley rats

Ayurvedic Medicine: A Traditional Medical System and Its Heavy Metal Poisoning

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