Toxicological, toxicokinetic and gastroprotective evaluation of the benzaldehyde semicarbazone

Evaluation of acute toxicity and gastroprotective activity of curcuma purpurascens BI. rhizome against ethanol-induced gastric mucosal injury in rats

“…One of the contributing factors in gastric ulcer formation is ethanol. Due to the rapid penetration of ethanol into the gastric mucosa, it is widely utilized to induce experimental gastric ulcer in numerous in vivo studies [ 29 – 31 ]. The elevation in mucosal permeability and release of vasoactive products by ethanol result in vascular damage and gastric cell necrosis prior to the ulcer formation.…”

Synthesis, insecticidal and fungicidal activities of methyl 2-(methoxyimino)-2-(2-((1-(N′-nitrocarbamimidoyl)-2-hydrocarbylidenehydrazinyl)methyl)phenyl)acetates

“…A weak electrondonating or -withdrawing substituent at this position, such as a chlorine atom (6)(7)(8)(9)(10)(6)(7)(8)(9)(10)(11)(12) or alkyl group (6-15, 6-16) was benecial. But a strong substituent, such as a cyano (6-09), nitro (6-13), or alkyloxy (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) group signicantly reduced the activity. These observations were used to clearly sketch out the outlines of a structure-activity relationship model for this series of compounds and to identify the direction for optimization.…”

“…11,12 The crucial moiety, N 0 -nitrohydrazinecarboximidamide, along with its structural analogs semicarbazones and thiosemicarbazones, is a core structure of many other bioactive molecules. [13][14][15][16][17][18][19] For this study, we considered combining (2-(2-methoxyimino)methoxycarbonyl methyl)benzyl, a very common toxophore in fungicides, such as in tri-oxystrobin (5), with N 0 -nitrohydrazinecarboximidamides, so that a new class of bioactive compounds (6) could be created and investigated for agricultural application (Fig. 1).…”