Toxicology and Forensic Entomology

Carvalho, Lucila Maria Lopes de

doi:10.1007/978-1-4020-9684-6_9

Cited by 12 publications

(15 citation statements)

References 31 publications

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“…A significantly accelerated growth rate was also observed by Bourel et al [66] for Lucilia sericata larvae feeding on tissues contaminated with morphine and by O'Brien and Turner [67] for Calliphora vicina larvae feeding on tissues contaminated with paracetamol. Diazepam also appeared to affect the size and shape of Chrysomya albiceps puparium [49]. Such studies demonstrate the risk of calculating an incorrect PMI min due to the drug modified rate of development of the immature stages [63] which can vary from a minimum of 18 h up to 96 h depending on the drug, the fly species, and the stage of development.…”

Section: Detection Of Drugs In Insectsmentioning

confidence: 96%

“…In such badly decomposed bodies, these immature stages and their remnants are not only useful for estimating the PMI min, but they can also be used as a reliable substrate for toxicological analysis, and can sometimes provide a more suitable biosample without any decomposition interference [47]. Most of the substances involved in drug-related deaths are detectable through analyses of maggots: opiates such as morphine and codeine, cocaine and benzoylecognine, amphetamines, tricyclic antidepressants, phenotiazines and benzodiazepines, steroids, barbiturates and several salicylates such as paracetamol [46,48,49]. Drugs and toxins have also been detected through analyses of empty puparial cases [50] and even beetle exuviae and fecal material [51].…”

Section: Detection Of Drugs In Insectsmentioning

confidence: 98%

“…The potential use of insects as alternative samples for detecting drugs and toxins has been well documented in the literature [44][45][46][47][48][49]. Fly larvae and pupae are often found on decomposing bodies and in their surroundings long after tissues traditionally sampled for toxicological analyses, such as blood, urine or solid organs, have disappeared.…”

Section: Detection Of Drugs In Insectsmentioning

confidence: 99%

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Forensic entomology: applications and limitations

Amendt¹,

Richards

Campobasso

et al. 2011

Forensic Sci Med Pathol

398

229

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Forensic entomology is the science of collecting and analysing insect evidence to aid in forensic investigations. Its main application is in the determination of the minimum time since death in cases of suspicious death, either by estimating the age of the oldest necrophagous insects that developed on the corpse, or by analysing the insect species composition on the corpse. In addition, toxicological and molecular examinations of these insects may help reveal the cause of death or even the identity of a victim, by associating a larva with its last meal, for example, in cases where insect evidence is left at a scene after human remains have been deliberately removed. Some fly species can develop not only on corpses but on living bodies too, causing myiasis. Analysis of larvae in such cases can demonstrate the period of neglect of humans or animals. Without the appropriate professional collection of insect evidence, an accurate and convincing presentation of such evidence in court will be hampered or even impossible. The present paper describes the principles and methods of forensic entomology and the optimal techniques for collecting insect evidence.

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Section: Detection Of Drugs In Insectsmentioning

confidence: 96%

Section: Detection Of Drugs In Insectsmentioning

confidence: 98%

Section: Detection Of Drugs In Insectsmentioning

confidence: 99%

See 1 more Smart Citation

Forensic entomology: applications and limitations

Amendt¹,

Richards

Campobasso

et al. 2011

Forensic Sci Med Pathol

398

229

View full text Add to dashboard Cite

show abstract

“…From a pure practical point of view, insects are of interest as they are present in high quantities and their remains (puparia or exuviae) are present for a long time, even when toxicological samples are no longer available [9]. In cases where religious and ethical beliefs result in problems collecting samples for toxicological analysis, insects could be a solution [10].…”

Section: Introductionmentioning

confidence: 99%

Entomotoxicology, experimental set-up and interpretation for forensic toxicologists

Gosselin¹,

Wille²,

Fernández³

et al. 2011

Forensic Science International

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“…Entomotoxicology also investigates the effects caused by drugs and toxins on arthropod development in order to assist the forensic postmortem interval estimates (Nolte et al 1992;Introna et al 2001). Most of the substances implicated in drug-related deaths are detectable through analyses of maggots: opiates such as morphine and codeine, cocaine and benzoylecognine, amphetamines, tricyclic antidepressants, phenothiazines and benzodiazepines, steroids, barbiturates, and several salicylates Carvalho 2010). Drugs and toxins have also been detected by analyzing of puparial cases (Pien et al 2004), and moreover, it is founded in beetle exuviae and fecal material (Miller et al 1994).…”

Section: Maggotmentioning

confidence: 99%

Helminthes and insects: maladies or therapies

El-Tantawy

2014

Parasitol Res

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By definition, parasites cause harm to their hosts. But, considerable evidence from ancient traditional medicine has supported the theory of using parasites and their products in treating many diseases. Maggots have been used successfully to treat chronic, long-standing, infected wounds which failed to respond to conventional treatment by many beneficial effects on the wound including debridement, disinfection, and healing enhancement. Maggots are also applied in forensic medicine to estimate time between the death and discovery of a corpse and in entomotoxicology involving the potential use of insects as alternative samples for detecting drugs and toxins in death investigations. Leeches are segmented invertebrates, famous by their blood-feeding habits and used in phlebotomy to treat various ailments since ancient times. Leech therapy is experiencing resurgence nowadays in health care principally in plastic and reconstructive surgery. Earthworms provide a source of medicinally useful products with potential antimicrobial, antiviral, and anticancer properties. Lumbrokinases are a group of fibrinolytic enzymes isolated and purified from earthworms capable of degrading plasminogen-rich and plasminogen-free fibrin and so can be used to treat various conditions associated with thrombotic diseases. Helminth infection has been proved to have therapeutic effects in both animal and human clinical trials with promising evidence in treating many allergic diseases and can block the induction of or reduce the severity of some autoimmune disorders as Crohn's disease or ulcerative colitis. What is more, venomous arthropods such as scorpions, bees, wasps, spiders, ants, centipedes, snail, beetles, and caterpillars. The venoms and toxins from these arthropods provide a promising source of natural bioactive compounds which can be employed in the development of new drugs to treat diseases as cancer. The possibility of using these active molecules in biotechnological processes can make these venoms and toxins a valuable and promising source of natural bioactive compounds. The therapeutic use of helminthes and insects will be of great value in biomedicine and further studies on insect toxins will contribute extensively to the development of Biomedical Sciences.

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Toxicology and Forensic Entomology

Cited by 12 publications

References 31 publications

Forensic entomology: applications and limitations

Forensic entomology: applications and limitations

Entomotoxicology, experimental set-up and interpretation for forensic toxicologists

Helminthes and insects: maladies or therapies

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