Toxicology and Pharmacology of the Lanthanides

Evans, Christopher H.

doi:10.1007/978-1-4684-8748-0_8

Cited by 24 publications

(16 citation statements)

References 115 publications

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“…Some researchers reported that REE can improve protein and other nutrient utilization through stimulating activities of the hormones such as growth hormone and T3 (Xie et al., ; Yang et al., ; He et al., ). In addition, the antimicrobial and antioxidant effects of REE have been reported for animals (Evans, ; Xie and Wang, ; He et al., ).…”

Section: Introductionmentioning

confidence: 99%

Effects of cerium oxide supplementation to laying hen diets on performance, egg quality, some antioxidant enzymes in serum and lipid oxidation in egg yolk

Al-Sagan

Ürüşan

et al. 2016

Animal Physiology Nutrition

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This study was conducted to determine the effects of dietary cerium oxide levels (0, 100, 200, 300 or 400 mg/kg) on the laying performance, egg quality, some blood serum parameters and egg lipid peroxidation of laying hen. In total, one hundred and twenty 22-week-old brown Lohman LSL laying hens were randomly assigned to five groups equally (n = 24). Each treatment was replicated six times. Dietary supplementation of cerium oxide had no significant effect on feed intake and egg weight. The addition of cerium oxide to the laying hens' feed improved feed conversion ratio and increased (p < 0.05) egg production. Quality criteria of egg for except shell breaking strength were not affected by supplementing cerium oxide. In particular, supplementation of 200 and 300 mg/kg cerium oxide to the laying hens feed led to a significant (p < 0. 01) increase in egg shell breaking strength. Calcium and phosphorus concentration of serum increased significantly (p < 0.05) with supplementation of 100 mg/kg cerium oxide to laying hen diets. It was also observed that serum superoxide dismutase (SOD) activity and malondialdehyde (MDA) concentration decreased significantly with supplementation of cerium oxide in diets. Inclusion of cerium oxide resulted in a significant reduction in thiobarbituric acid reactive substance (TBARS) values in egg yolk in this study. It can be concluded that the addition of cerium oxide had positive effects on egg production, feed conversion ratio and egg shelf life. Based on the results of this study, it could be advised to supplement laying hens feed with cerium oxide as feed additives.

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Section: Introductionmentioning

confidence: 99%

Effects of cerium oxide supplementation to laying hen diets on performance, egg quality, some antioxidant enzymes in serum and lipid oxidation in egg yolk

Al-Sagan

Ürüşan

et al. 2016

Animal Physiology Nutrition

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“…Radioactive labels and most organic dyes are hazardous, are limited in dynamic range, and pose storage difficulties due to their flammability or limited useful lifetime. Lanthanides are relatively innocuous due to poor absorption in the gastrointestinal tract and, even when injected, normally cannot penetrate living cells. , …”

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confidence: 99%

Ultratrace Determination of Selected Lanthanides by Luminescence Enhancement

Jenkins

Murray

1996

Anal. Chem.

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The luminescence intensity of trivalent lanthanides, especially terbium(III) and europium(III), is shown to be enhanced by coordination with the ligand 2,6-pyridinedicarboxylic acid (DPA). Further enhancement can be obtained by forming a columinescent complex aggregate with ions such as gadolinium(III), terbium(III), lanthanum(III), or yttrium(III), where the Y(III) complex shows the greatest enhancement. A surfactant, sodium dodecyl sulfate (SDS), can be added to the solution to enhance the luminescence intensity of many lanthanide-ligand complexes by segregating the complex from quenchers. In this study, SDS has little effect on the limit of detection, but it does act to extend the linear dynamic range to include higher concentrations. The combination of columinescent complex with surfactant resulted in decreased luminescence intensity coupled with an increase in the background due to the light scattered by the surfactant micelles. A mechanism for the enhancement of the lanthanide luminescent intensity by energy transfer has been described by Xu et al. This study differs in that a lanthanide ion excitation band represents the most efficient excitation path and not a ligand excitation band. The complexes examined in this study have advantages over those used in prior studies since they do not require surfactants to achieve low limits of detection (100 parts per quadrillion, ppq, for Eu(DPA)(3)(3)(-) and 60 ppq for Tb(DPA)(3)(3)(-)), and they exhibit longer linear dynamic ranges (from 4 to 6 decades) than other columinescent systems.

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“…Our results suggest an uptake of Gd via phagocytosis either associated with organic medium compounds of proteose peptone or in the form of free ions. There are several suggested roles for the organic compound proteose peptone in this process: Besides providing essential nutrients, organic media compounds can stimulate food vacuole formation 63,64 , and for REE, it is known that they can speciate with organic medium compounds 11,65 . In general, the toxicity of heavy metals decreases with increasing organic content in the medium 25,28 .…”

Section: Discussionmentioning

confidence: 99%

Intracellular bioaccumulation of the rare earth element Gadolinium in ciliate cells resulting in biogenic particle formation and excretion

Kohl

Schweikert

Klaas

et al. 2023

Sci Rep

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Ciliates are abundant unicellular organisms capable of resisting high concentrations of metal ions in the environment caused by various anthropogenic activities. Understanding the cellular pathways involved in resistance to and detoxification of elements is required to predict the impact of ciliates on environmental element cycles. Here, we investigated the so far unknown process of tolerance, cellular uptake and bioaccumulation of the emerging rare earth element gadolinium (Gd) in the common ciliate Tetrahymena pyriformis. Gd treatment results in the intracellular formation and excretion of biogenic Gd-containing particles. This cellular process effectively removes dissolved Gd from the organic growth medium by 53.37% within 72 h. Based on light and electron microscopic observations, we postulate a detoxification pathway: Cells take up toxic Gd3+ ions from the medium by endocytosis, process them into stable Gd-containing particles within food vacuoles, and exocytose them. Stable biogenic particles can be isolated, which are relatively homogeneous and have a diameter of about 3 µm. They consist of the elements Gd, C, O, P, Na, Mg, K, and Ca. These findings broaden the view of metal ion accumulation by protists and are of relevance to understand environmental elemental cycles and may inspire approaches for metal recovery or bioremediation.

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Toxicology and Pharmacology of the Lanthanides

Cited by 24 publications

References 115 publications

Effects of cerium oxide supplementation to laying hen diets on performance, egg quality, some antioxidant enzymes in serum and lipid oxidation in egg yolk

Effects of cerium oxide supplementation to laying hen diets on performance, egg quality, some antioxidant enzymes in serum and lipid oxidation in egg yolk

Ultratrace Determination of Selected Lanthanides by Luminescence Enhancement

Intracellular bioaccumulation of the rare earth element Gadolinium in ciliate cells resulting in biogenic particle formation and excretion

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