Toxicology Update

R, Von Burg

doi:10.1002/jat.2550120116

Cited by 9 publications

(2 citation statements)

References 3 publications

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“…Ni is increasing related to weight or BMI this is may be due to excessive meal intake that containing Ni results from food processing methods apparently add to the nickel levels already present in foodstuffs via: 1. Leaching from nickel-containing alloys in food processing equipments made from stainless steel; 2. the milling of flour; 3.catalytic hydrogenation of fats and oils by use of nickel catalysts [20]. Rich food sources of nickel include oatmeal, dried beans and peas, nuts, dark chocolate and soya products, and consumption of these products in larger amounts may increase the nickel intake to 900 µg/person/day or more [21].…”

Section: Discussionmentioning

confidence: 99%

Determination of Nickel Concentration in the Breast Milk of Lactating Mothers Living In Hilla City, Babylon, Iraq

Nassir

Al-Sharify

Baiee

2018

JUBPAS

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Background Human milk is the only source of food for infants during the first four to five months of their life. Some chemicals compood can be transferred from the body stores and from blood into the breast milk of a lactating mother. Objectives To determining and measurements of Nickel leval the human milk and to identify the associations of certain potential variables with the concentrations of these heavy metals. Subjects and Methods This is a cross-sectional study carried included a milk test by a randomly selected (68) women apparently healthy lactating women, who attended Babylon Maternity & children hospital in Al – Hilla city during the period mid of February through the end of April 2012. Breast milk was collected and analyzed to detect and measure Nickel using atomic absorption. A questionnaire paper was prepared to recorded the demographic variables. Weights and heights were measured to calculate the Body Mass Index. Results This study revealed that the mean concentrations of Nickel in the human milk was (23.83±15.57 ppb) which was remarkably high as compared with the concentrations reported by other studies done in other countries. The study shows that there was a statistically significant association (p<0.0s) between the high concentrations of Nickel and the followings associates ; living in urban regions ,living near highways , living near industrial regions and drinking river or tap water, being younger (<3oyears of age) or heaver increase weight and being cigarettes smokers. The prevalence rates of lactating mothers with abnormal concentrations of was 99%and 93% respectively indicating the serious environmental pollution in Hilla city. Conclusion Breast milk of lactating mothers in Hilla city is abnormally contaminated with; Nickel this public health problem need to be addressed.

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Section: Discussionmentioning

confidence: 99%

Determination of Nickel Concentration in the Breast Milk of Lactating Mothers Living In Hilla City, Babylon, Iraq

Nassir

Al-Sharify

Baiee

2018

JUBPAS

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“…brain). It is highly non‐toxic (estimated human lethal dose 0.5–5 g·kg −1 ) and non‐sensitizing (Von Burg, 1995)…”

Section: Cannabis Terpenoids: Neglected Entourage Compounds?mentioning

confidence: 99%

Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects

Russo

2011

British J Pharmacology

1,283

1,071

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Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it. More recently, the synergistic contributions of cannabidiol to cannabis pharmacology and analgesia have been scientifically demonstrated. Other phytocannabinoids, including tetrahydrocannabivarin, cannabigerol and cannabichromene, exert additional effects of therapeutic interest. Innovative conventional plant breeding has yielded cannabis chemotypes expressing high titres of each component for future study. This review will explore another echelon of phytotherapeutic agents, the cannabis terpenoids: limonene, myrcene, a-pinene, linalool, b-caryophyllene, caryophyllene oxide, nerolidol and phytol. Terpenoids share a precursor with phytocannabinoids, and are all flavour and fragrance components common to human diets that have been designated Generally Recognized as Safe by the US Food and Drug Administration and other regulatory agencies. Terpenoids are quite potent, and affect animal and even human behaviour when inhaled from ambient air at serum levels in the single digits ng·mL -1. They display unique therapeutic effects that may contribute meaningfully to the entourage effects of cannabis-based medicinal extracts. Particular focus will be placed on phytocannabinoid-terpenoid interactions that could produce synergy with respect to treatment of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections (including methicillin-resistant Staphylococcus aureus). Scientific evidence is presented for non-cannabinoid plant components as putative antidotes to intoxicating effects of THC that could increase its therapeutic index. Methods for investigating entourage effects in future experiments will be proposed. Phytocannabinoid-terpenoid synergy, if proven, increases the likelihood that an extensive pipeline of new therapeutic products is possible from this venerable plant.

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Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents

Cruzan¹,

Borghoff²,

Peyster³

et al. 2007

Regulatory Toxicology and Pharmacology

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Toxicology Update

Abstract: Note: The Toxicology Update represents a brief review of an often extensive literature base. Only some of the directly related references may he included.

Cited by 9 publications

References 3 publications

Determination of Nickel Concentration in the Breast Milk of Lactating Mothers Living In Hilla City, Babylon, Iraq

Determination of Nickel Concentration in the Breast Milk of Lactating Mothers Living In Hilla City, Babylon, Iraq

Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects

Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents

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