Toxicometallomics of Cadmium, Manganese and Arsenic with Special Reference to the Roles of Metal Transporters

Himeno, Seiichiro; Sumi, Daigo; Fujishiro, Hitomi

doi:10.5487/tr.2019.35.4.311

Cited by 20 publications

(10 citation statements)

References 50 publications

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“…Mutant rice that was obtained by using ion-beam irradiation has begun to be cultivated in Japan. In this rice, the function of OsNramp5 is lost, and thus Cd is not accumulated [72].…”

Section: Exposure To Cadmium and Toxicitymentioning

confidence: 95%

“…Under normal physiological conditions, MTs bind zinc and copper, while the binding to cadmium depends on the accumulation of this metal ion in the kidney, which varies with age. In mammalian cells, Zn transporters, such as ZIP8 and ZIP14, have been reported to function as transporters for Mn(II) and Cd(II), contributing to the maintenance of Mn homeostasis and metallothionein-independent transports of Cd, respectively [72].…”

Section: Cadmium and Metallothioneinsmentioning

confidence: 99%

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The Effects of Cadmium Toxicity

Genchi

Sinicropi

Lauria

et al. 2020

IJERPH

1,616

602

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Cadmium (Cd) is a toxic non-essential transition metal that poses a health risk for both humans and animals. It is naturally occurring in the environment as a pollutant that is derived from agricultural and industrial sources. Exposure to cadmium primarily occurs through the ingestion of contaminated food and water and, to a significant extent, through inhalation and cigarette smoking. Cadmium accumulates in plants and animals with a long half-life of about 25–30 years. Epidemiological data suggest that occupational and environmental cadmium exposure may be related to various types of cancer, including breast, lung, prostate, nasopharynx, pancreas, and kidney cancers. It has been also demonstrated that environmental cadmium may be a risk factor for osteoporosis. The liver and kidneys are extremely sensitive to cadmium’s toxic effects. This may be due to the ability of these tissues to synthesize metallothioneins (MT), which are Cd-inducible proteins that protect the cell by tightly binding the toxic cadmium ions. The oxidative stress induced by this xenobiotic may be one of the mechanisms responsible for several liver and kidney diseases. Mitochondria damage is highly plausible given that these organelles play a crucial role in the formation of ROS (reactive oxygen species) and are known to be among the key intracellular targets for cadmium. When mitochondria become dysfunctional after exposure to Cd, they produce less energy (ATP) and more ROS. Recent studies show that cadmium induces various epigenetic changes in mammalian cells, both in vivo and in vitro, causing pathogenic risks and the development of various types of cancers. The epigenetics present themselves as chemical modifications of DNA and histones that alter the chromatin without changing the sequence of the DNA nucleotide. DNA methyltransferase, histone acetyltransferase, histone deacetylase and histone methyltransferase, and micro RNA are involved in the epigenetic changes. Recently, investigations of the capability of sunflower (Helianthus annuus L.), Indian mustard (Brassica juncea), and river red gum (Eucalyptus camaldulensis) to remove cadmium from polluted soil and water have been carried out. Moreover, nanoparticles of TiO2 and Al2O3 have been used to efficiently remove cadmium from wastewater and soil. Finally, microbial fermentation has been studied as a promising method for removing cadmium from food. This review provides an update on the effects of Cd exposure on human health, focusing on the cellular and molecular alterations involved.

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“…Mutant rice that was obtained by using ion-beam irradiation has begun to be cultivated in Japan. In this rice, the function of OsNramp5 is lost, and thus Cd is not accumulated [72].…”

Section: Exposure To Cadmium and Toxicitymentioning

confidence: 95%

Section: Cadmium and Metallothioneinsmentioning

confidence: 99%

The Effects of Cadmium Toxicity

Genchi

Sinicropi

Lauria

et al. 2020

IJERPH

1,616

602

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“…Retrograde axonal transport of toxic metals to the LC neuronal cell bodies could result in accumulation of these toxicants [21]. (3) Metal transporters are responsible for the selective uptake of metals such as mercury, cadmium, iron, and manganese in several different cell types [71][72][73]. Future studies of the cellular distribution of these metal transporters in LC neurons could shed light on their role in the selective uptake of metals.…”

Section: Plos Onementioning

confidence: 99%

Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus

et al. 2020

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Objective Damage to locus ceruleus neurons could play a part in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis because of impairment of the blood-brain barrier and enhanced neuroinflammation. The locus ceruleus has connections throughout the brain and spinal cord, so the characteristic widespread multifocal pathology in these disorders could be due to damage to different subsets of locus ceruleus neurons. Previous studies have shown that only certain locus ceruleus neurons accumulate the neurotoxic metal mercury. To find out if concentrations of other toxic metals or of essential trace elements also vary between individual locus ceruleus neurons, we used synchrotron X-ray fluorescence microscopy on frozen sections of locus ceruleus neurons taken from people with multiple sclerosis, in whom the locus ceruleus is structurally intact.

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“…In an aerobic environment, mostly the arsenate [As(V)] form predominates, whereas the arsenite [As(III)] form is predominant in anaerobic conditions. A higher As(III) contamination in paddy fields due to water logged conditions and the presence of a potential As(III) accumulator plant, rice, are both of serious concern [9,10].…”

Section: Introductionmentioning

confidence: 99%

Arsenic Remediation through Sustainable Phytoremediation Approaches

et al. 2021

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Arsenic contamination of the environment is a serious problem threatening the health of millions of people exposed to arsenic (As) via drinking water and crops grown in contaminated areas. The remediation of As-contaminated soil and water bodies needs to be sustainable, low-cost and feasible to apply in the most affected low-to-middle income countries, like India and Bangladesh. Phytoremediation is an aesthetically appreciable and successful approach that can be used for As decontamination with use of the best approach(es) and the most promising plant(s). However, phytoremediation lacks the required speed and sometimes the stress caused by As could diminish plants’ potential for remediation. To tackle these demerits, we need augment plants’ potential with appropriate technological methods including microbial and nanoparticles applications and genetic modification of plants to alleviate the As stress and enhance As accumulation in phytoremediator plants. The present review discusses the As phytoremediation prospects of soil and water bodies and the usefulness of various plant systems in terms of high biomass, high As accumulation, bioenergy potential, and economic utility. The potential and prospects of assisted phytoremediation approaches are also presented.

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Toxicometallomics of Cadmium, Manganese and Arsenic with Special Reference to the Roles of Metal Transporters

Cited by 20 publications

References 50 publications

The Effects of Cadmium Toxicity

The Effects of Cadmium Toxicity

Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus

Arsenic Remediation through Sustainable Phytoremediation Approaches

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