Toxicopathologic and pharmacologic properties of piperacetazine, a potent tranquilizing agent

Weaver, Lawrence C.; Mitchell, Frank E.; Kerley, T.L.

doi:10.1016/0041-008x(63)90081-4

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…The potency of piperacetazine as compared with chlorpromazine is presented in the following Acute toxicity Mouse 0.5 activity, reduced resistance to handling, marked ataxia, and profound depression with higher doses. 2 Subacute toxicity. Quide ( piperacetazine) was administered orally for a period of 90 days at dosage levels of up to 50 mg./kg./day in rats and 40 mg./Kg./day in dogs.…”

Section: Pharmacologymentioning

confidence: 99%

Piperacetazine (Quide tablets)

1969

Clin Pharma and Therapeutics

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Section: Pharmacologymentioning

confidence: 99%

Piperacetazine (Quide tablets)

1969

Clin Pharma and Therapeutics

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“…pyl}-phenothiazine) and benzosulfonate (1-methyl-2-{-(2-methylsulfinyl-dibenzothiazinyl 10)-ethyl-1 }-piperidine) have been recently synthesized (4,5). Hence it is of interest to determine if they possess antiarrhythmic activity.…”

mentioning

confidence: 99%

Effect of Two Recently Synthesized Phenothiazine Derivatives Upon Experimental Cardiac Arrhythmias

Madan

1971

Jpn.J.Pharmacol

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Chlorpromazine has been reported to suppress cardiac arrhythrnias produced ex perimentally (1, 2) and those observed in clinical practice (3). Two new phenothiazine derivatives, namely piperacetazine (2-acetyl-10-{-3 [-4-(fl-hydroxyethyl)-piper] dine] pro pyl}-phenothiazine) and benzosulfonate (1-methyl-2-{-(2-methylsulfinyl-dibenzothiazinyl 10)-ethyl-1 }-piperidine) have been recently synthesized (4, 5). Hence it is of interest to determine if they possess antiarrhythmic activity. MATERIAL AND METHODSFreshly prepared I % solutions in isotonic saline of benzosulfonate and piperacetazine were used. Cardiac arrhythmias were produced in vagotornized mongrel dogs of both sexes weighing between 8 and 18 kg by the following techniques:1. Acetylcholine-induced atrial fibrillation Twelve animals were anaesthetized with intravenous pentobarbital sodium, 30 mg/ kg. Atrial fibrillation was produced according to the method of Scherf and Chick (6) which was followed in all essential details as described by Schallek (7). A small pledget of cotton soaked in 5 per cent acetylcholine was placed on the area of sino-atrial node.One minute later, atrial fibrillation was induced by pinching the atrium and its duration noted. Two such controls were taken after which the procedure was repeated a third time. After the atria were fibrillating for a minute, the drug to be tested was injected and reduction in the duration of fibrillation noted. Atrial flutter incluced by injury-stimulationAccording to the method of Rosenblueth and Garcia Ramos (8) 3. Aconitine-induced atrial arrhythmia Atrial arrhythmia was produced by the method of Scherf (9) in 13 dogs which were anaesthetized as above. A cotton pledget soaked in 0.05% solution of aconitine hydro

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Piperacetazine 3819‐00‐9

2004

Sax's Dangerous Properties of Industrial Materials

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Toxicopathologic and pharmacologic properties of piperacetazine, a potent tranquilizing agent

Cited by 4 publications

References 3 publications

Piperacetazine (Quide tablets)

Piperacetazine (Quide tablets)

Effect of Two Recently Synthesized Phenothiazine Derivatives Upon Experimental Cardiac Arrhythmias

Piperacetazine 3819‐00‐9

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