Toxicopathological effects of feeding aflatoxins B1 in broilers and its ameliosration with indigenous mycotoxin binder

Saleemi, Muhammad Kashif; Ashraf, Kamran; Gul, Shafia Tehseen; Naseem, Muhammad Noman; Sajid, Marina; Mohsin, Mashkoor; He, Cheng; Zubair, Muhammad; Khan, Ahrar

doi:10.1016/j.ecoenv.2019.109712

Cited by 47 publications

(43 citation statements)

References 28 publications

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“…AFB 1 can also cause apoptosis, gross and histopathological lesions in different organs, especially in liver, kidney, muscles and bursa of Fabricius (Chen et al 2014;Peng et al 2014). It was reported that AFB 1 intoxication could increase mortality, liver and kidney pathology, and decrease bodyweight and feed intake for broilers (Saleemi et al 2019). Therefore, it is necessary to develop effective detoxification strategies to increase AFB 1 degradation and alleviate AFB 1 -induced inflammatory and immunosuppression in chickens.…”

Section: Introductionmentioning

confidence: 99%

Effects of compound probiotics and aflatoxin-degradation enzyme on alleviating aflatoxin-induced cytotoxicity in chicken embryo primary intestinal epithelium, liver and kidney cells

et al. 2021

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Aflatoxin B1 (AFB1) is one of the most dangerous mycotoxins for humans and animals. This study aimed to investigate the effects of compound probiotics (CP), CP supernatant (CPS), AFB1-degradation enzyme (ADE) on chicken embryo primary intestinal epithelium, liver and kidney cell viabilities, and to determine the functions of CP + ADE (CPADE) or CPS + ADE (CPSADE) for alleviating cytotoxicity induced by AFB1. The results showed that AFB1 decreased cell viabilities in dose-dependent and time-dependent manners. The optimal AFB1 concentrations and reactive time for establishing cell damage models were 200 µg/L AFB1 and 12 h for intestinal epithelium cells, 40 µg/L and 12 h for liver and kidney cells. Cell viabilities reached 231.58% (p < 0.05) for intestinal epithelium cells with CP addition, 105.29% and 115.84% (p < 0.05) for kidney and liver cells with CPS additions. The further results showed that intestinal epithelium, liver and kidney cell viabilities were significantly decreased to 87.12%, 88.7% and 84.19% (p < 0.05) when the cells were exposed to AFB1; however, they were increased to 93.49% by CPADE addition, 102.33% and 94.71% by CPSADE additions (p < 0.05). The relative mRNA abundances of IL-6, IL-8, TNF-α, iNOS, NF-κB, NOD1 (except liver cell) and TLR2 in three kinds of primary cells were significantly down-regulated by CPADE or CPSADE addition, compared with single AFB1 group (p < 0.05), indicating that CPADE or CPSADE addition could alleviate cell cytotoxicity and inflammation induced by AFB1 exposure through suppressing the activations of NF-κB, iNOS, NOD1 and TLR2 pathways.

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Section: Introductionmentioning

confidence: 99%

Effects of compound probiotics and aflatoxin-degradation enzyme on alleviating aflatoxin-induced cytotoxicity in chicken embryo primary intestinal epithelium, liver and kidney cells

et al. 2021

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“…Various segments of nephrons are attached by aflatoxins in addition to its metabolites. The possible reason, the aflatoxin prompts protein reduction so increases the kidney cells necrosis 17 . Previous studies reported that exposer to aflatoxins induced kidney syndromes 18 , deteriorating variations in renal tubular cells in addition to unusual change of glomerular epithelial cells 19 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Aflatoxin B1 and Patulinin Blood of Iraqi Renal Failure patients

Basaad Abdzaid AL-Fatlawi

2021

MLU

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Objectives: The current study aimed to investigate and evaluatethe Aflatoxin B1 and Patulin in blood samples of patients with Renal Failure. Method:Hundred fifty blood samples collected from patients with Renal Failure were included in this study. The agerange of patients was 1-61 years. Toxin extraction from the samples was done by Thin Layer Chromatography technique (TLC).Results: There were 100 from 150 samples of blood containedAflatoxinB1and Patulin. The highest percentage blood samples contamination with Aflatoxin B1 was (18.181 %) at age group (11-30) years and Patulin was (20 %) that collected from persons at age group (11-20) years,the percentage of blood samples that contamination withAflatoxin B1 and Patulin that collected from the female was (52.727 % and 53.33%). Conclusion:Persons in Najaf province high exposure to mycotoxins from foods (apples,pear and peach) that present in local markets, that are contaminated with mycotoxins. This suggests that these mycotoxins may be a risk factor of renal failure.

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“…Published data have shown that the toxicity of aflatoxin negatively affect the productivity, reproductive performance, morphological and histopathological changes, as well as immune system of birds (Saleemi et al, 2020;Mogadam & Azizpour, 2011;Magnoli et al, 2011;Bryden, 2012;Yunus et al, 2011;Peng et al, 2015). According to Fouad et al (2019), the concentration of aflatoxin in feed was the main factor associated with the occurrence of aflatoxicosis in poultry.…”

Section: Growth Performancementioning

confidence: 99%

The Performance, Nutrient Digestibility, Aflatoxin B1 Residue, and Histopathological Changes of Broilers Exposed to Dietary Mycosorb

Nalle¹,

Supit²,

Angi

et al. 2021

Trop. Anim. Sci. J.

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Aflatoxin B1 (AFB1) is the most dangerous type of aflatoxin that can impair poultry productivity even in low concentrations. The harmful effects of AFB1 should be minimized. The present study was conducted to evaluate the performance, nutrient digestibility, AFB1 residue, and histopathological changes of broilers fed AFB1 diets supplemented with mycosorb. Two hundred-forty 1-day old broiler chicks were allocated randomly to 24 pens (10 birds/pen). The experimental design was a 4 x 2 factorial arrangement, with AFB1 level and yeast glucomannan (mycosorb) supplementation as the main factors. The treatment diets were control diet; control diet + mycosorb; AFB1 diets (10.36 ppb); AFB1 diets (10.36 ppb) + mycosorb; AFB1 diets (26.97 ppb); AFB1 diets (26.97 ppb) + mycosorb; AFB1 diets (61.06 ppb); AFB1 diets (61.06 ppb) + mycosorb. The results showed that there was no interaction effect was found between the level of AFB1 and mycosorb on the performance and nutrient digestibility. The level of AFB1 did not affect dry matter digestibility coefficient but affected (p<0.05) crude fat digestibility coefficient of broilers. Except for proventriculus, level of AFB1 did not affect bird’s gut size. AFB1 residue was not detected in the broiler tissues fed all diets. Mycosorb alone ameliorated (p<0.05) feed conversion ratio (FCR) of growing birds. The birds fed 61.06 ppb AFB1 diets had darker liver than those fed similar diets added with mycosorb. The addition of mycosorb in AFB1 diets did not heal the hemorrhagic intestines of the birds. In conclusion, feeding low level of AFB1 diets added with mycosorb did not improve the bird’s performance, nutrient digestibility, or gut health. Mycosorb alone improved feed efficiency of the experimental birds.

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Toxicopathological effects of feeding aflatoxins B1 in broilers and its ameliosration with indigenous mycotoxin binder

Cited by 47 publications

References 28 publications

Effects of compound probiotics and aflatoxin-degradation enzyme on alleviating aflatoxin-induced cytotoxicity in chicken embryo primary intestinal epithelium, liver and kidney cells

Effects of compound probiotics and aflatoxin-degradation enzyme on alleviating aflatoxin-induced cytotoxicity in chicken embryo primary intestinal epithelium, liver and kidney cells

Evaluation of Aflatoxin B1 and Patulinin Blood of Iraqi Renal Failure patients

The Performance, Nutrient Digestibility, Aflatoxin B1 Residue, and Histopathological Changes of Broilers Exposed to Dietary Mycosorb

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