Toxicopathological evaluation of Picralima nitida seed aqueous extract in Wistar rats

Haematological Profile and Some Reproductive Indices of Male Albino Rats Treated with Ethanolic Stem Bark Extract of Picralima nitida

“…It could also be as a result of imbalance in the rate of production and destruction of blood corpuscles (erythropoiesis) as a result of administration of this extract. Sunmonu et al however reported no significant difference in the erythrocyte count rats treated with the aqueous extract of P. nitida seed when compared to the control group [48]. The erythrocyte count of rats administered cadmium chloride was the lowest.…”

“…This could also imply that either the incorporation of haemoglobin into the red blood cells or the morphology and osmotic fragility of the red blood cells were altered at the administration of the high dose (400 mg/kg body weight) of the extract. Again, Sunmonu et al [48] who used of the aqueous seed extract of P. nitida reported no significant effect on haemoglobin concentration of Wistar rats. The disparity observed may be as a result of difference in the phytochemical composition in different parts of this plant or the difference in the extraction solvent utilized.…”

“…It implies that the ethanolic stem bark extract of P. nitida is tolerable when administered at a dose of 100 mg/kg but have profound deleterious effects on the histoarchitecture of the testes when administered at higher doses of 200 mg/kg body weight and 400 mg/kg body weight. Other researchers [48] have reported that the ethanolic extract of P. nitida seed when administered at low doses produced no cellular abnormality of the spermatozoa in the testes and considered safe for consumption in animal model compared to chronic administration of high doses which are toxic and could pose deleterious effects to the testes which play vital Similarly, cadmium has also been reported to cause testicular necrosis among other toxic potentials [58].…”

“…The neutrophilia and monocytopenia observed with ethanolic stem bark extract in this research has been previously reported when rats were treated with seed extract of Picralima nitida. It has been suggested that it could be traced to usual inflammatory process or immune response accompanying injection of substances considered foreign by the animal's body, especially as toxic components are suspected to be contained in the plant extract and the heavy metal, leading to selective immune modulatory effect and localized toxicity [48].…”

Free Radical Scavenging Property of <i>Picralima nitida</i> Seed Extract on Malaria-Induced Albino Mice

“…In animals infected with Schistosoma mansonii, treatment with artesunate caused significant decrease in expression of Schistosome thioredoxin reductase and cytochrome c peroxidase compared to treatment with praziquantal [30]. Taofit et al [31] conducted a research on the toxicopathological evaluation of Picralima nitida seed aqueous extract in Wistar rats and found out that the extract exhibited mild and selected toxicity on the liver.…”