Toxicoproteomics: Preclinical Studies

Merrick, B. Alex; Bruno, Maribel

doi:10.1002/9780470249055.ch25

Preclinical Development Handbook 2007

DOI: 10.1002/9780470249055.ch25

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Toxicoproteomics: Preclinical Studies

B. Alex Merrick

Maribel Bruno

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2015

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Cited by 1 publication

References 109 publications

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Proteomics in pharmaceutical research and development

Cutler

Voshol

2015

Proteomics Clinical Apps

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In the 20 years since its inception, the evolution of proteomics in pharmaceutical industry has mirrored the developments within academia and indeed other industries. From initial enthusiasm and subsequent disappointment in global protein expression profiling, pharma research saw the biggest impact when relating to more focused approaches, such as those exploring the interaction between proteins and drugs. Nowadays, proteomics technologies have been integrated in many areas of pharmaceutical R&D, ranging from the analysis of therapeutic proteins to the monitoring of clinical trials. Here, we review the development of proteomics in the drug discovery process, placing it in a historical context as well as reviewing the current status in light of the contributions to this special issue, which reflect some of the diverse demands of the drug and biomarker pipelines.

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Proteomics in pharmaceutical research and development

Cutler

Voshol

2015

Proteomics Clinical Apps

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Toxicoproteomics: Preclinical Studies

Cited by 1 publication

References 109 publications

Proteomics in pharmaceutical research and development

Proteomics in pharmaceutical research and development

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