Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis

Yu, Chunlin; Yin, Xiujing; Li, Aoyu; Li, Rongfeng; Yu, Huahua; Xing, Ronge; Liu, Song; Li, Pengcheng

doi:10.1016/j.jprot.2023.105048

Cited by 3 publications

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Severe systemic allergic reactions sometimes occur, mainly due to prior exposure to antigenic toxins or similar biological components, and species-specific immunoglobulin antibodies in serum can remain high for several years [ 16 , 26 ]. Moreover, the multiple bioactive constituents within jellyfish venom can elicit immune responses via associated signaling pathways and cellular mechanisms [ 27 , 28 ]. For instance, Yap et al proposed that cnidarian pore-forming toxins (PFTs) exhibit similarities to bacterial PFTs, which can induce K + efflux by penetrating the plasma membrane.…”

Section: Immune Responsesmentioning

confidence: 99%

Jellyfish Stings: A Review of Skin Symptoms, Pathophysiology, and Management

Peng,

Liu,

Chen

et al. 2024

Med Sci Monit

View full text Add to dashboard Cite

With the surge in the human coastal population and the increasing frequency of human activities along the coast, cases of marine envenomation, particularly jellyfish envenomation, have notably risen. Jellyfish stings can induce a spectrum of symptoms that vary in severity, encompassing skin injuries, acute systemic venom effects, delayed indirect sequelae, and even fatality, causing significant distress to patients. Among these manifestations, the occurrence of skin lesions following jellyfish stings is prevalent and substantial. These lesions are characterized by evident blister formation, development of bullae, subcutaneous hemorrhage, erythema, papules, wheal, ecchymosis, and ulceration or skin necrosis. Local cutaneous manifestations may persist for several weeks or even months after the initial sting. Despite aggressive treatment, many skin injuries still result in significant pigmentation or scarring after recovery. To address this issue effectively, it is imperative to conduct comprehensive evidence-based medical research, elucidate various components within jellyfish venom, and elucidate its pathogenic mechanism to develop targeted treatment programs. This article aims to review the skin symptoms, pathophysiology, and management of jellyfish stings. Such considerations can provide comprehensive guidance to medical professionals and the public and minimize the harm caused by jellyfish stings.

show abstract

Section: Immune Responsesmentioning

confidence: 99%

Jellyfish Stings: A Review of Skin Symptoms, Pathophysiology, and Management

Peng,

Liu,

Chen

et al. 2024

Med Sci Monit

View full text Add to dashboard Cite

show abstract

Real-time precision detection algorithm for jellyfish stings in neural computing, featuring adaptive deep learning enhanced by an advanced YOLOv4 framework

Zhu,

Feng,

2024

Front. Neurorobot.

View full text Add to dashboard Cite

IntroductionSea jellyfish stings pose a threat to human health, and traditional detection methods face challenges in terms of accuracy and real-time capabilities.MethodsTo address this, we propose a novel algorithm that integrates YOLOv4 object detection, an attention mechanism, and PID control. We enhance YOLOv4 to improve the accuracy and real-time performance of detection. Additionally, we introduce an attention mechanism to automatically focus on critical areas of sea jellyfish stings, enhancing detection precision. Ultimately, utilizing the PID control algorithm, we achieve adaptive adjustments in the robot's movements and posture based on the detection results. Extensive experimental evaluations using a real sea jellyfish sting image dataset demonstrate significant improvements in accuracy and real-time performance using our proposed algorithm. Compared to traditional methods, our algorithm more accurately detects sea jellyfish stings and dynamically adjusts the robot's actions in real-time, maximizing protection for human health.Results and discussionThe significance of this research lies in providing an efficient and accurate sea jellyfish sting detection algorithm for intelligent robot systems. The algorithm exhibits notable improvements in real-time capabilities and precision, aiding robot systems in better identifying and addressing sea jellyfish stings, thereby safeguarding human health. Moreover, the algorithm possesses a certain level of generality and can be applied to other applications in target detection and adaptive control, offering broad prospects for diverse applications.

show abstract

Elucidation of Medusozoan (Jellyfish) Venom Constituent Activities Using Constellation Pharmacology

Yanagihara,

Giglio,

Hurwitz

et al. 2024

Toxins

View full text Add to dashboard Cite

Within the phylum Cnidaria, sea anemones (class Anthozoa) express a rich diversity of ion-channel peptide modulators with biomedical applications, but corollary discoveries from jellyfish (subphylum Medusozoa) are lacking. To bridge this gap, bioactivities of previously unexplored proteinaceous and small molecular weight (~15 kDa to 5 kDa) venom components were assessed in a mouse dorsal root ganglia (DRG) high-content calcium-imaging assay, known as constellation pharmacology. While the addition of crude venom led to nonspecific cell death and Fura-2 signal leakage due to pore-forming activity, purified small molecular weight fractions of venom demonstrated three main, concentration-dependent and reversible effects on defined heterogeneous cell types found in the primary cultures of mouse DRG. These three phenotypic responses are herein referred to as phenotype A, B and C: excitatory amplification (A) or inhibition (B) of KCl-induced calcium signals, and test compound-induced disturbances to baseline calcium levels (C). Most notably, certain Alatina alata venom fractions showed phenotype A effects in all DRG neurons; Physalia physalis and Chironex fleckeri fractions predominantly showed phenotype B effects in small- and medium-diameter neurons. Finally, specific Physalia physalis and Alatina alata venom components induced direct excitatory responses (phenotype C) in glial cells. These findings demonstrate a diversity of neuroactive compounds in jellyfish venom potentially targeting a constellation of ion channels and ligand-gated receptors with broad physiological implications.

show abstract

Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis

Cited by 3 publications

References 55 publications

Jellyfish Stings: A Review of Skin Symptoms, Pathophysiology, and Management

Jellyfish Stings: A Review of Skin Symptoms, Pathophysiology, and Management

Real-time precision detection algorithm for jellyfish stings in neural computing, featuring adaptive deep learning enhanced by an advanced YOLOv4 framework

Elucidation of Medusozoan (Jellyfish) Venom Constituent Activities Using Constellation Pharmacology

Contact Info

Product

Resources

About