Toxoplasma gondii autophagy-related protein ATG7 maintains apicoplast inheritance by stabilizing and lipidating ATG8

Wu, Mimi; Ying, Jiaqi; Lin, Xuejing; Xu, Chao; Zheng, Xiaozi; Zheng, Yi; Fang, Zhouxi; Yan, Baolong; Zhang, Nu; Mou, Yani; Tan, Feng

doi:10.1016/j.bbadis.2023.166891

Cited by 5 publications

(3 citation statements)

References 66 publications

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“…Both of these systems are activated by the same E1-like enzyme, Atg7. LC3-I is activated by Atg7 and binds to phosphatidylethanolamine in the membrane to form LC3-II, which promotes the formation of autophagosomes and mediates autophagy . Chen et al found that Atg7 deletion would lead to impaired autophagy, thereby increasing the severity of skin damage associated with radiation exposure in mice.…”

Section: Discussionmentioning

confidence: 99%

“…LC3-I is activated by Atg7 and binds to phosphatidylethanolamine in the membrane to form LC3-II, which promotes the formation of autophagosomes and mediates autophagy. 55 Chen et al 56 found that Atg7 deletion would lead to impaired autophagy, thereby increasing the severity of skin damage associated with radiation exposure in mice. Wang et al 57 showed that Atg7 overexpression activates autophagy, thereby improving cardiac dysfunction induced by pressure overload and fetoproteinrelated cardiomyopathy.…”

Section: Discussionmentioning

confidence: 99%

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Lycopene Regulates Macrophage Immune Response through the Autophagy Pathway Mediated by RIPK1

Yao,

Liu,

Niu

et al. 2024

J. Agric. Food Chem.

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The effects of lycopene (LP) on macrophage immune responses were evaluated in this study. Compared with the control treatment, LP treatment significantly increased cell vitality, phagocytic activity, and chemokine production in RAW264.7 cells. Additionally, compared with the control treatment, 4 μM LP treatment significantly activated autophagy, enhanced mitochondrial membrane potential, and upregulated receptor-interacting protein kinase 1 (RIPK1), while necrostatin-1 significantly reversed these effects of LP. Furthermore, compared with that in the control group, RIPK1 was significantly upregulated in the 4 μM LP and 4 μM LP + spautin-1 groups, whereas p-mTOR levels were reduced. More importantly, compared with that in the control group, p62 was significantly downregulated, and Beclin1, LC3-II, and Atg7 were upregulated in the 4 μM LP group, while spautin-1 significantly reversed these effects of LP. These results confirm that LP activates the mTOR/Beclin1/LC3/p62 autophagy signaling pathway through RIPK1, thereby enhancing the immune response of macrophages.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lycopene Regulates Macrophage Immune Response through the Autophagy Pathway Mediated by RIPK1

Yao,

Liu,

Niu

et al. 2024

J. Agric. Food Chem.

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“…Autophagy is an evolutionarily conserved process that maintaining intracellular homeostasis by eliminating dysfunctional organelles, protein aggregates, and senescent proteins ( Levine and Kroemer, 2008 ). When pathogens (including DNA viruses, RNA viruses, bacteria, and parasites) infect host cells, they can induce immune responses such as autophagy within host cells ( Kimura et al., 2017 ; Liu et al., 2019 ; Xiao and Cai, 2020 ; Wu et al., 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Autophagy as a dual-faced host response to viral infections

Zhai,

Wang,

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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Autophagy selectively degrades viral particles or cellular components, either facilitating or inhibiting viral replication. Conversely, most viruses have evolved strategies to escape or exploit autophagy. Moreover, autophagy collaborates with the pattern recognition receptor signaling, influencing the expression of adaptor molecules involved in the innate immune response and regulating the expression of interferons (IFNs). The intricate relationship between autophagy and IFNs plays a critical role in the host cell defense against microbial invasion. Therefore, it is important to summarize the interactions between viral infections, autophagy, and the host defense mechanisms against viruses. This review specifically focuses on the interactions between autophagy and IFN pathways during viral infections, providing a comprehensive summary of the molecular mechanisms utilized or evaded by different viruses.

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TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in Toxoplasma gondii

Thaprawat,

Zhang,

Rentchler

et al. 2024

Autophagy Reports

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Toxoplasma gondii autophagy-related protein ATG7 maintains apicoplast inheritance by stabilizing and lipidating ATG8

Cited by 5 publications

References 66 publications

Lycopene Regulates Macrophage Immune Response through the Autophagy Pathway Mediated by RIPK1

Lycopene Regulates Macrophage Immune Response through the Autophagy Pathway Mediated by RIPK1

Autophagy as a dual-faced host response to viral infections

TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in Toxoplasma gondii

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