Toxoplasma infection and systemic lupus erythematosus: analysis of the serological response by immunoblotting.

Noel, I; Balfour, A H; Wilcox, Michael

doi:10.1136/jcp.46.7.628

Cited by 12 publications

(4 citation statements)

References 23 publications

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“…A high T. gondii antibody seroprevalence (as well as to the cytomegalovirus and the Epstein-Barr virus) has been observed in systemic lupus erythematosus, and it has been suggested that antibodies raised to the pathogen may contribute to the autoimmunity characteristic of this condition via pathogen/host protein mimicry [16, 54, 55]. Conversely, T. gondii infection has been shown to prevent the development of lupus-related nephritis in rabbits [56], a factor perhaps related to the immunosuppressant properties of parasitic infection.…”

Section: Resultsmentioning

confidence: 99%

Toxoplasmosis and Polygenic Disease Susceptibility Genes: ExtensiveToxoplasma gondiiHost/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

Carter

2013

Journal of Pathogens

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Toxoplasma gondii is not only implicated in schizophrenia and related disorders, but also in Alzheimer's or Parkinson's disease, cancer, cardiac myopathies, and autoimmune disorders. During its life cycle, the pathogen interacts with ~3000 host genes or proteins. Susceptibility genes for multiple sclerosis, Alzheimer's disease, schizophrenia, bipolar disorder, depression, childhood obesity, Parkinson's disease, attention deficit hyperactivity disorder (P from 8.01E − 05 (ADHD) to 1.22E − 71) (multiple sclerosis), and autism (P = 0.013), but not anorexia or chronic fatigue are highly enriched in the human arm of this interactome and 18 (ADHD) to 33% (MS) of the susceptibility genes relate to it. The signalling pathways involved in the susceptibility gene/interactome overlaps are relatively specific and relevant to each disease suggesting a means whereby susceptibility genes could orient the attentions of a single pathogen towards disruption of the specific pathways that together contribute (positively or negatively) to the endophenotypes of different diseases. Conditional protein knockdown, orchestrated by T. gondii proteins or antibodies binding to those of the host (pathogen derived autoimmunity) and metabolite exchange, may contribute to this disruption. Susceptibility genes may thus be related to the causes and influencers of disease, rather than (and as well as) to the disease itself.

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Section: Resultsmentioning

confidence: 99%

Toxoplasmosis and Polygenic Disease Susceptibility Genes: ExtensiveToxoplasma gondiiHost/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

Carter

2013

Journal of Pathogens

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“…First, we should note that it is not uncommon for adult sera to manifest naturally occurring antibodies against T. gondii [33] and the presence of these natural antibodies could reflect the crossreactivity of parasite antigens with antigens from the host [27]. This is well supported by the observation that ATxA from healthy individuals cross-react with malignant cervical tissue antigens [34].…”

Section: Discussionmentioning

confidence: 97%

“…Previous case reports and case-control studies have linked ATxA with polymyositis [16], rheumatoid arthritis (RA) [17e19], autoimmune thyroid diseases [20,21], Crohn's disease [22], anti phospholipid syndrome [23], Wegener's granulomatosis [24] and autoimmune bullous diseases [25]. While ATxA have been previously associated with SLE [26], subsequent studies challenged this association [27,28]. In our recent study conducted in type 1 diabetes mellitus patients, we found a negative association of ATxA with this autoimmune disease [29].…”

Section: Introductionmentioning

confidence: 95%

Prevalence of anti-toxoplasma antibodies in patients with autoimmune diseases

Shapira¹,

Agmon‐Levin²,

Selmi³

et al. 2012

Journal of Autoimmunity

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“…Also, some parasitic infections play several significant roles in the formation and worsening of autoimmune diseases. For example, the traces of toxoplasmosis have been noticed in many autoimmune diseases, such as autoimmune thyroid disease, systemic sclerosis, rheumatoid arthritis, and discoid lupus erythematosus (5)(6)(7). It seems that parasite and host antigens' high resemblance can cause autoimmune disorders by a parasitic infection (7).…”

Section: Introductionmentioning

confidence: 99%

The Role of Toxoplasma gondii Infection Among Multiple Sclerosis Patient Compared to Ordinary People in South of Iran: A Case-Control Study

et al. 2020

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Background: Toxoplasmosis is a common parasitic disease, which leads to serious disease symptoms in immunocompromised hosts and infants. Recent epidemiologic surveys showed that microbial agents may be associated with some cases of multiple sclerosis (MS). Objectives: This case-control study aimed to examine the role of Toxoplasma gondii in MS by evaluating sero-frequency of anti-T. gondii IgG (ATXAb) antibody between patients with MS and ordinary people in Shiraz Province, south of Iran during 2016 - 2018. Methods: Serum samples obtained from MS patients (n = 130), and a group of age and gender-matched controls (n = 130) with the same socioeconomic status with the patients’ group were collected to evaluate the prevalence of T. gondii IgG antibodies (ATXAb). Moreover, the presence of the ATXAb antibody of the patients and controls was determined by the ELISA test. SPSS 20 software was used to perform the statistical analysis (SPSS, inc., Chicago, USA). Results: Out of 130 (35.4%) cases with MS and 130 (13.8%) controls, 46 and 18 subjects were seropositive for ATXAb, respectively. Based on the chi-square test, a significant difference was observed in terms of the positivity rates of ATXAb between the MS patient group and the control group (P = 0.001). The mean ± standard deviation ATXAb levels in controls and MS patients were found to be 61 ± 34 and 114 ± 47 IU/mL, respectively. Also, there were statistically significant differences between the levels of these two groups (P = 0.001). Conclusions: Given the relationship between toxoplasmosis and MS, it is possible that the prevalence of MS decreases by increasing hygiene and preventing toxoplasmosis.

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Toxoplasma infection and systemic lupus erythematosus: analysis of the serological response by immunoblotting.

Cited by 12 publications

References 23 publications

Toxoplasmosis and Polygenic Disease Susceptibility Genes: ExtensiveToxoplasma gondiiHost/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

Toxoplasmosis and Polygenic Disease Susceptibility Genes: ExtensiveToxoplasma gondiiHost/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

Prevalence of anti-toxoplasma antibodies in patients with autoimmune diseases

The Role of Toxoplasma gondii Infection Among Multiple Sclerosis Patient Compared to Ordinary People in South of Iran: A Case-Control Study

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