Toxoplasmose médullaire au cours de l’infection à VIH

Pittner, Y.; Dufour, J.-F.; David, Gary; Boibieux, A.; Peyramond, D.

doi:10.1016/j.medmal.2008.10.016

Cited by 6 publications

(1 citation statement)

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“…Review of the literature [1,2,3,5,6,7,10,11,12,13,14, 15,16,17,18,19,20,23,24,25,26,27,29,30,32,33] shows that virtually all cases of toxoplasmic myelitis or spinal cord lesions occurred either in persons who were immunecompromised by HIV infections or malignancies or their treatments or occasionally in infants with congenital toxoplasmosis at birth [3,23,28]. Herein, we describe our experience in the US National Collaborative Congenital Toxoplasmosis Study, where we have encountered 3 newborn infants with toxoplasmic spinal cord lesions.…”

Section: Discussionmentioning

confidence: 99%

Spinal Cord Lesions in Congenital Toxoplasmosis Demonstrated with Neuroimaging, Including Their Successful Treatment in an Adult

Burrowes

Boyer²,

Swisher³

et al. 2012

J. Neuroparasitol.

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Neuroimaging studies for persons in the National Collaborative Chicago-Based Congenital Toxoplasmosis Study (NCCCTS) with symptoms and signs referable to the spinal cord were reviewed. Three infants had symptomatic spinal cord lesions, another infant a Chiari malformation, and another infant a symptomatic peri-spinal cord lipoma. One patient had an unusual history of prolonged spinal cord symptoms presenting in middle age. Neuroimaging was used to establish her diagnosis and response to treatment. This 43 year-old woman with congenital toxoplasmosis developed progressive leg spasticity, weakness, numbness, difficulty walking, and decreased visual acuity and color vision without documented re-activation of her chorioretinal disease. At 52 years of age, spinal cord lesions in locations correlating with her symptoms and optic atrophy were diagnosed with 3 Tesla MRI scan. Treatment with pyrimethamine and sulfadiazine decreased her neurologic symptoms, improved her neurologic examination, and resolved her enhancing spinal cord lesions seen on MRI.

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