Toxoplasmosis

Montoya, José G.; Contopoulos‐Ioannidis, Despina G.

doi:10.1007/978-3-030-63384-4_5

Cited by 7 publications

(5 citation statements)

References 89 publications

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“…In recent years, medical professionals have become increasingly aware of the risk posed by toxoplasmosis to pregnant women and their growing fetus 15,23 . Disease transmission can be minimized by increasing disease awareness and knowledge, particularly among women of childbearing age.…”

Section: Discussionmentioning

confidence: 99%

An Observational Study to Assess the Level of Awareness and Perception of Toxoplasmosis among women of Childbearing age in Gaza City, Palestine

Dardona,

Hindi,

Hafidi

et al. 2023

PJMHS

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Background: Toxoplasmosis is one of the world's most ubiquitous parasitic infections. According to numerous published studies and data, this disease affects approximately one-third of the world's population. In addition, it is caused by the obligatory intracellular parasite, Toxoplasma gondii. Aim: To assess the level of toxoplasmosis awareness and knowledge among women of childbearing age in Gaza City, Palestine, as well as determine potential risk factors for toxoplasmosis. It is worth emphasizing that the researched region, Gaza City, is one of the world's most densely populated cities. Method: The study's assessment approach involved the distribution of 400 questionnaires to women of childbearing age. Aside from gender and age, no other criteria were considered for assessment purposes. Results: The findings of this questionnaire revealed that 38.25% of respondents had heard of this disease, 47.00% were knowledgeable about the means of transmission, and 35.00% were aware of the measures for managing and preventing toxoplasmosis. The most shocking finding was that merely 21.50% of respondents received counseling or information about this ailment, either through educational stages or from their treating physician. Additionally, the findings revealed that consuming raw meat, rearing domestic cats, direct contact with stray cats, and soil are all-important potential risk factors for acquiring this disease. Conclusion: As a result, the study attempted to shed light on the inadequacy of toxoplasmosis knowledge and awareness, particularly among women of childbearing age in the study region. Considering this, the study recommends additional efforts to raise and develop a strong standard for toxoplasmosis knowledge and awareness among women of childbearing age in the study area. Key words: Toxoplasmosis – childbearing age – awareness – risk factors – Gaza, Palestine.

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Section: Discussionmentioning

confidence: 99%

An Observational Study to Assess the Level of Awareness and Perception of Toxoplasmosis among women of Childbearing age in Gaza City, Palestine

Dardona,

Hindi,

Hafidi

et al. 2023

PJMHS

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“…As taxas mais altas são encontradas em países da América Latina, enquanto as taxas mais baixas são relatadas no Sudeste Asiático. (20,21) No Brasil, a prevalência de soropositividade em gestantes é elevada, sendo mais frequente em mulheres com baixa condição socioeconômica e em regiões rurais. (18) A associação entre lesões oculares e T congênita está bem estabelecida e inclui principalmente retinocoroidite, atrofia do nervo óptico, estrabismo e microftalmia, mas existe casos raros de maculopatia em torpedo.…”

Section: Kun Et Al (2018)unclassified

“…(5) Assim, um achado clássico nos recém-nascidos que desenvolvem catarata por T é uma cicatriz coriorretiniana extensa, podendo também vir acompanhada de descolamento de retina. (21) Cataratas subcapsulares posteriores são observadas com mais frequência, seguidas de cataratas nucleares, subcapsulares anteriores e polares anteriores. (23) Em casos de catarata unilateral, pode-se observar diferença na avaliação clínica oftalmológica entre os dois olhos, devendo ser levado em conta para o melhor resultado cirúrgico.…”

Section: Kun Et Al (2018)unclassified

Catarata congênita nas infecções intrauterinas mais comuns (STORCH): revisão de literatura

Yang,

Bosso,

Freire

et al. 2024

Revista Brasileira De Oftalmologia

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“…Humans contract infection by the parasite either horizontally by accidental ingestion of oocysts shed in feline feces or by ingestion of tissue cysts that persist in the muscles and nervous system of the intermediate hosts during consumption of undercooked meat or by consumption of food or drink contaminated with oocysts accidentally ( Dubey, 2009 ). The parasite can also transmitted vertically by transplacental infection with tachyzoites passed from the mother to their offspring ( Montaya and Liesenfeld, 2004 ; Montoya and Contopoulos-Ioannidis, 2021 ). This wide range of hosts and several modes of transmission reflects the importance of toxoplasmosis as a typical zoonotic disease for all warm-blooded animals, including humans ( Tenter et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Tamoxifen Increased Parasite Burden and Induced a Series of Histopathological and Immunohistochemical Changes During Chronic Toxoplasmosis in Experimentally Infected Mice

et al. 2022

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The global distribution of breast cancer and the opportunistic nature of the parasite have resulted in many patients with breast cancer becoming infected with toxoplasmosis. However, very limited information is available about the potential effects of tamoxifen on chronic toxoplasmosis and its contribution to the reactivation of the latent infection. The present study investigated the potential effects of tamoxifen on chronic toxoplasmosis in animal models (Swiss albino mice). Following induction of chronic toxoplasmosis and treatment with the drug for 14 and 28 days, the anti-parasitic effects of tamoxifen were evaluated by parasitological assessment and counting of Toxoplasma cysts. In addition, the effects of the drug on the parasite load were evaluated and quantitated using TaqMan real-time quantitative PCR followed by investigation of the major histopathological changes and immunohistochemical findings. Interestingly, tamoxifen increased the parasite burden on animals treated with the drug during 14 and 28 days as compared with the control group. The quantification of the DNA concentrations of Toxoplasma P29 gene after the treatment with the drug revealed a higher parasite load in both treated groups vs. control groups. Furthermore, treatment with tamoxifen induced a series of histopathological and immunohistochemical changes in the kidney, liver, brain, and uterus, revealing the exacerbating effect of tamoxifen against chronic toxoplasmosis. These changes were represented by the presence of multiple T. gondii tissue cysts in the lumen of proximal convoluted tubules associated with complete necrosis in their lining epithelium of the kidney section. Meanwhile, liver tissue revealed multiple T. gondii tissue cysts in hepatic parenchyma which altered the structure of hepatocytes. Moreover, clusters of intracellular tachyzoites were observed in the lining epithelium of endometrium associated with severe endometrial necrosis and appeared as diffuse nuclear pyknosis combined with sever mononuclear cellular infiltration. Brain tissues experienced the presence of hemorrhages in pia mater and multiple T. gondii tissue cysts in brain tissue. The severity of the lesions was maximized by increasing the duration of treatment. Collectively, the study concluded novel findings in relation to the potential role of tamoxifen during chronic toxoplasmosis. These findings are very important for combating the disease, particularly in immunocompromised patients which could be life-threatening.

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Toxoplasmosis

Cited by 7 publications

References 89 publications

An Observational Study to Assess the Level of Awareness and Perception of Toxoplasmosis among women of Childbearing age in Gaza City, Palestine

An Observational Study to Assess the Level of Awareness and Perception of Toxoplasmosis among women of Childbearing age in Gaza City, Palestine

Catarata congênita nas infecções intrauterinas mais comuns (STORCH): revisão de literatura

Tamoxifen Increased Parasite Burden and Induced a Series of Histopathological and Immunohistochemical Changes During Chronic Toxoplasmosis in Experimentally Infected Mice

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