Toxoplasmosis-associated abortion and stillbirth in Tehran, Iran

Ghasemi, Fatemeh; Rasti, Sima; Piroozmand, Ahmad; Bandehpour, Mojgan; Kazemi, Bahram; Mousavi, Seyed Gholam Abbas; Abdoli, Amir

doi:10.3109/14767058.2014.996127

Cited by 27 publications

(33 citation statements)

References 20 publications

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“…Based on the results of Ghasemi et al. (2015a,b), only the T. gondii IgM seropositivity was significantly higher in women with abortion (3.6%) than normal delivery women (0.9%) ( P = 0.37%). Also, Ghasemi et al.…”

Section: Discussionmentioning

confidence: 94%

“…; Ghasemi et al. ). The overall seroprevalence rates of toxoplasmosis are 39.9% (95% CI: 26.1–53.7) among childbearing age women in Iran (Borna et al.…”

Section: Discussionmentioning

confidence: 97%

“…; Ghasemi et al. ). On the other hand, there is little information about the impact of ToRCH co‐infections on the outcome of pregnancy.…”

Section: Introductionmentioning

confidence: 97%

“…Hence, congenital infections predominantly occur in mothers that acquired these infections in the first time during pregnancy (Shet 2011;Vergnano and Heath 2013). However, several studies reported an association between ToRCH seropositivity with a history of bad obstetric outcomes (Turbadkar et al 2003;Aljumaili et al 2013;Ramana et al 2013;Alsamarai et al 2014;Malik et al 2014;Ghasemi et al 2015b). On the other hand, there is little information about the impact of ToRCH co-infections on the outcome of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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ToRCH “co‐infections” are associated with increased risk of abortion in pregnant women

Rasti

Ghasemi

Abdoli

et al. 2016

Congenital Anomalies

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ToRCH infections (toxoplasmosis, rubella, cytomegalovirus and Herpes simplex virus) have long been known to be associated with bad obstetric outcomes. However, little information is available about the impact of ToRCH co-infections on the outcome of pregnancy. Hence, we tested the IgG and IgM antibodies to Toxoplasma gondii, Rubella, Cytomegalovirus and Herpes Simplex Virus among 81 pregnant women with abortion (case group) and 98 pregnant women with normal delivery (control group). In the single-infection model, only CMV-IgM seropositivity was significantly increased in case than control group (25.9% in case and 12.2 % in control, OR = 2.5, P = 0.019). In the co-infection model, 14 patterns were recognized, but two patterns were significantly increased in the case than the control group. Co-infection of T. gondii IgG + CMV IgM was 9.1-fold increased in the case than the control group (8.6% in the case and 1% in control, OR = 9.1; P = 0.024). Also, co-infection of T. gondii IgG + HSV IgG + CMV IgM was 7.7-fold increased in case than the control group (7.4% in case and 1 % in control, OR = 7.7; P = 0.04). Although the OR of other co-infections was higher in the case than the control group, the difference was not statistically significant. These findings indicate that ToRCH co-infections are associated with increased risk of abortion than single infection. Hence, the rates of co-infections should be considered in prenatal screening of ToRCH infections.

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Section: Discussionmentioning

confidence: 94%

“…; Ghasemi et al. ). The overall seroprevalence rates of toxoplasmosis are 39.9% (95% CI: 26.1–53.7) among childbearing age women in Iran (Borna et al.…”

Section: Discussionmentioning

confidence: 97%

“…; Ghasemi et al. ). On the other hand, there is little information about the impact of ToRCH co‐infections on the outcome of pregnancy.…”

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

ToRCH “co‐infections” are associated with increased risk of abortion in pregnant women

Rasti

Ghasemi

Abdoli

et al. 2016

Congenital Anomalies

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“…Sporulated oocytes act as an infection source for intermediate and final hosts of the parasite (Chikweto et al, ). T. gondii is an important cause of congenital anomalies and miscarriage in humans and animals (Abdoli et al, ; Ghasemi et al, ; Rasti et al, ; Remington & Desmonts, ). Toxoplasmosis in chickens usually has no symptoms, but rarely observed symptoms, such as anorexia, emaciation, decreased egg production, blindness and death (Dubey, ).…”

Section: Introductionmentioning

confidence: 99%

Molecular detection and genotype identification of Toxoplasma gondii in domestic and industrial eggs

Khademi

Ghaffarifar

Dalimi

et al. 2018

Journal of Food Safety

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Birds are important intermediated hosts of Toxoplasma gondii. Consumption of chicken meat and its infected products is one of the main sources of human infection with T. gondii. However, little information is available about T. gondii infection in egg. In this study, the contamination of industrial and local eggs with Toxoplasma was investigated by PCR method targeting the RE gene in two tropical cities of Iran. Genotypes of T. gondii were determined by PCR‐RFLP method targeting the SAG3 gene. T. gondii DNA was detected in 11% (22/200) of the eggs. Genotyping of 14 T. gondii isolates revealed that all of the isolates were belonged to genotype III of T. gondii. Sequencing of the isolates by the SAG3 gene showed 95%–100% similarity with the T. gondii isolates in GenBank. Practical applications The findings of this study suggested that consumption of raw or undercooked eggs might play a role in human infection with Toxoplasma. Hence, consumption of adequately cooked eggs should be considered for prevention of human toxoplasmosis.

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Identification and multilocus genotyping of Toxoplasma gondii isolates from congenital infection in north of Iran

et al. 2022

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Toxoplasmosis-associated abortion and stillbirth in Tehran, Iran

Cited by 27 publications

References 20 publications

ToRCH “co‐infections” are associated with increased risk of abortion in pregnant women

ToRCH “co‐infections” are associated with increased risk of abortion in pregnant women

Molecular detection and genotype identification of Toxoplasma gondii in domestic and industrial eggs

Identification and multilocus genotyping of Toxoplasma gondii isolates from congenital infection in north of Iran

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