Toxoplasmosis, Lymphoma, or Both?

Barlotta, Flora M.; Ochoa, Manuel; Neu, Harold C.; Ultmann, John E.

doi:10.7326/0003-4819-70-3-517

Cited by 23 publications

(1 citation statement)

References 43 publications

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“…Protozoa: Toxoplasma gondii may cause severe foetal or neonatal disease, but clinical manifestations in older children and adults are usually mild. However, fatal generalized toxoplasmosis may occur in patients receiving immunosuppressive drugs after homotransplantation, or in those suffering from malignant disease of the lymphoreticular system (Reynolds et al 1966, Vietzke et al 1968, Barlotta et al 1969. Vietzke et al described extensive necrotizing encephalitis in patients developing toxoplasma infection secondary to malignant disease.…”

Section: Morbid Anatomical and Histological Features Of Unusual Infecmentioning

confidence: 99%

The Complications of Immunosuppression

Gowing

1970

Proceedings of the Royal Society of Medicine

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Section: Morbid Anatomical and Histological Features Of Unusual Infecmentioning

confidence: 99%

The Complications of Immunosuppression

Gowing

1970

Proceedings of the Royal Society of Medicine

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Skin Lesions With Disseminated Toxoplasmosis in a Patient With the Acquired Immunodeficiency Syndrome

Hirschmann¹,

Chu

1988

Arch Dermatol

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membrane may be decreased, absent, or biochemically altered. Structural and/or functional abnormalities may exist within the epidermis of skin from patients with EB simplex that, in the presence of heat and/or mechanical trauma, lead to intraepidermal blister formation.These abnormalities within both groups suggest that there are several distinct functional and biochemical abnormalities in patients with recessive dystrophic EB and in some patients with EB simplex. In recessive dystro¬ phic EB, these abnormalities may contribute directly to blister formation.Retinoids may be reasonable therapy for certain forms of EB. Recent studies have shown that certain retinoids inhibit collagenase and gelatinase activity in human skin fibroblast cultures, suggesting that retinoids can modulate collagenase in vitro by two mechanisms: by decreasing the synthesis of collagenase and by inducing the synthesis of a fibroblast-derived inhibitor of collagenase activity. A pilot study using low-dose (0.4 mg/kg/d) isotretinoin in three patients with severe recessive dystrophic EB showed a mean reduction of 67% in the number of bullae.4 However, etretinate therapy was found to be ineffective in one patient with recessive dystrophic EB.5Our patient with localized EB simplex had a marked reduction in blistering and acceleration in healing of blisters while receiving low-dose isotretinoin. We conclude that retinoids, in particular isotretinoin, may be a useful therapeutic option in patients with EB simplex.

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Acquired Toxoplasmosis

et al. 1975

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The neurological manifestations of six cases of acquired central nervous system toxoplasmosis are compared with the 39 well-documented cases from the literature. Half of the patients had underlying systemic diseases (18 malignant neoplasms, two renal transplants, three collagen vascular diseases) treated with intensive immunosuppressive therapy. The remainder had primary toxoplasmosis. Three major neurological patterns were seen: (1) diffuse encephalopathy with or without seizures, (2) meningoencephalitis, and (3) singular or multiple progressive mass lesions. Routine neurological diagnostic studies were not helpful. The Sabin-Feldman dye test or IgM indirect fluorescent antibody test or both were effective in confirming the diagnosis. Twenty-seven patients died without a clinical diagnosis of toxoplasmosis. The diagnosis was made terminally in four additional patients. Thirteen of fourteen patients who received a full course of sulfadiazine or pyrimethamine or both did well. Toxoplasmosis should be considered in the immunosuppressed patient who appears with neurological involvement.

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Toxoplasmosis, Lymphoma, or Both?

Cited by 23 publications

References 43 publications

The Complications of Immunosuppression

The Complications of Immunosuppression

Skin Lesions With Disseminated Toxoplasmosis in a Patient With the Acquired Immunodeficiency Syndrome

Acquired Toxoplasmosis

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