Toxoplasmosis, Pancreatitis, Obesity and Drug Discovery

Oz, Helieh S.

doi:10.4172/2165-7092.1000138

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…These findings support the concept that Toxoplasma may contribute to the pathogenesis of autoimmune disease. 2,41,42 Chronic IBD is mainly of Crohn's disease and ulcerative colitis. IBD is an autoimmune with altered gut microbiome and an exaggerated immune response, with excess toxins released from gram-negative lipopolysaccharide (LPS), bypassing the compromised, and leaky inflamed gut mucosa.…”

Section: Toxoplasmosis and Autoimmune Diseasementioning

confidence: 99%

Fetomaternal and Pediatric Toxoplasmosis

2017

J Pediatr Infect Dis

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Toxoplasmosis is one of the most important causes of foodborne illnesses and inflammatory complications, as well as congenital disorders. Promiscuous Toxoplasma is transmitted by contaminated food and animal produce, water, vegetations, fruits and sexually through semen. Toxoplasma infects nucleated cells with a unique tropism for muscles and central nervous system and a mind bugging malicious effect. Pregnant women with acute or reactivated toxoplasmosis can transmit Toxoplasma via transplacental to the fetus. The severity of congenital toxoplasmosis depends on the gestation period, as infection in early pregnancy causes more severe consequences. Congenital toxoplasmosis complications include miscarriage, encephalitis, neurological retardation, mental illnesses, auditory and visual inflammatory disorders, cardiovascular abnormalities, and pains. Current therapies are inefficient for congenital and chronic toxoplasmosis or have severe side effects with life threatening complications. There is an urgent need for effective and safe therapeutic modalities to treat complications of toxoplasmosis and effective vaccines to eliminate the infectious agent. This investigation will discuss pathogenesis of feto-maternal, congenital and pediatric toxoplasmosis, the current available therapies in practice, and explore those therapeutic modalities in experimental stages for promising future trials.

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Section: Toxoplasmosis and Autoimmune Diseasementioning

confidence: 99%

Fetomaternal and Pediatric Toxoplasmosis

2017

J Pediatr Infect Dis

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Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies

Majidiani

Dalvand

Daryani

et al. 2016

The Brazilian Journal of Infectious Diseases

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Association between serum amylase levels and CD4 cell counts in newly diagnosed people living with HIV: A case-control study

Yang

Xia

et al. 2023

Medicine

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Serum amylase is a direct reflection of pancreatic injury. Several clinical studies have indicated that antiretroviral therapy may be the main cause of increased serum amylase in people living with human immunodeficiency virus (PLWH). However, other probable causes including direct human immunodeficiency virus infection, opportunistic infections and neoplasms, alcohol abuse, and use of illicit drugs, which can also affect pancreatic amylase levels were not considered in these studies. In our study, we collected clinical data from newly diagnosed PLWH who had not received antiretroviral therapy, and examined the association between serum amylase levels and CD4 cell counts. Between November 2018 and September 2021, a total of 344 newly diagnosed PLWH and 344 healthy controls were recruited at Ningbo Yinzhou No 2 Hospital. Serum amylase levels, CD4 cell counts and other clinical features were measured. Relationships between serum amylase levels and clinical parameters were evaluated using correlation analysis. Multiple linear regression analyses were performed to identify the independent risk factors. Newly diagnosed PLWH had lower CD4 cell counts and higher serum amylase levels than healthy controls ( P < .05). Serum amylase levels were negatively correlated with CD4 cell counts ( r = −0.506, P < .001). In multiple linear regression analyses, CD4 cell counts (β = −0.327, 95% confidence interval = −0.051–−0.022, P < .001) were independently associated with serum amylase levels. CD4 cell counts were independently associated with serum amylase levels in newly diagnosed PLWH. Thus, close monitoring of serum amylase may be significant in preventing opportunistic infections of PLWH, since low CD4 cell counts are associated with an increased risk of opportunistic infections.

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Toxoplasmosis, Pancreatitis, Obesity and Drug Discovery

Cited by 4 publications

References 25 publications

Fetomaternal and Pediatric Toxoplasmosis

Fetomaternal and Pediatric Toxoplasmosis

Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies

Association between serum amylase levels and CD4 cell counts in newly diagnosed people living with HIV: A case-control study

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