Toxoplasmosis seroprevalence in rheumatoid arthritis patients: A systematic review and meta-analysis

Hosseininejad, Zahra; Sharif, Mehdi; Sarvi, Shahabeddin; Amouei, Afsaneh; Hosseini, Seyed Abdollah; Nayeri, Tooran; Anvari, Davood; Saberi, Reza; Gohardehi, Shaban; Mizani, Azadeh; Sadeghi, Mitra

doi:10.1371/journal.pntd.0006545

Cited by 43 publications

(35 citation statements)

References 41 publications

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“…We pooled each study estimate using a random-effects model to obtain an overall summary estimate of each Echinococcus isolate genotype (G1, G2, G3, and G6), as well as the accompanying 95% confidence intervals (CIs). Heterogeneity between the results was assessed based on the Q test and the I 2 indicator [37-39]. In addition, the Egger test was used to investigate the presence of publication bias.…”

Section: Methodsmentioning

confidence: 99%

A systematic review and meta-analysis of the genetic characterization of human echinococcosis in Iran, an endemic country

et al. 2019

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Human echinococcosis is an infectious disease caused by tapeworms belonging to the species Echinococcus. This parasite has a worldwide distribution and is considered a neglected tropical disease by the World Health Organization. Due to the diversity of Echinococcus spp. hosts, as well as variation in geographical, climatic, and socio-ethnic conditions, the question of the strains or genotypes of Echinococcus spp. that are involved in human infections is important. The aim of this study was to provide a summary of the available data on genotypes of Echinococcus obtained from the Iranian population. Four international databases (PubMed, Scopus, Science Direct, and Web of Science) and 4 Persian databases (Magiran, Scientific Information Database, Iran Medex, and IranDoc) were searched for cross-sectional studies that reported the genotypes of Echinococcus spp. in human echinococcosis cases using molecular methods in Iran through July 2018. The Newcastle-Ottawa Scale was used to assess the quality of the selected studies. A total of 559 cases of human cystic echinococcosis were reported in the 21 included articles. The majority of cases belonged to genotype G1 (89.2%; 95% confidence interval [CI], 80.1 to 95.8), genotype G6 (8.2%; 95% CI, 2.8 to 15.9), and genotype G3 (2.3%; 95% CI, 1.1 to 3.9). Since genotype G1 of Echinococcus appears to be the most prevalent genotype affecting humans in Iran, disease control initiatives aimed at sheep intermediate hosts may be the most beneficial. In addition, educational programs and serological screening in individuals may help reduce the national impact of the disease.

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Section: Methodsmentioning

confidence: 99%

A systematic review and meta-analysis of the genetic characterization of human echinococcosis in Iran, an endemic country

et al. 2019

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“…[ 7 8 ] Women during pregnancy and immunocompromised persons (cancer, Rheumatoid arthritis, transplant, and HIV/AIDS infected) include the high risk groups for T. gondii . [ 9 10 11 12 ]…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of toxoplasma gondii infection: An umbrella review of updated systematic reviews and meta-analyses

Rahmanian

Jahromi

et al. 2020

J Family Med Prim Care

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Objectives: Toxoplasmosis is one of the neglected parasitic disease in humans and animals that produced via toxoplasma gondii. This study we implemented an umbrella review of all existing systematic reviews, meta-analyzing studies to apprise, and summarize seroprevalence of human toxoplasmosis in worldwide. Methods: The search was carried out in databases including: Pub Med, Google Scholar, Science Direct, Scopus, Web of Science, Cochrane, and global health from their start dates until December 2018 in Persian and English language. A total of 21 systematics review and meta-analysis met the inclusion criteria of umbrella review. The Q test and the I 2 statistic were used to evaluate heterogeneities. Quality assessment were performed and made use of the AMSTAR tool. Results: The estimated pooled seroprevalence of T. gondii infection in blood donors, Immunocompromised patients, childbearing age women, general population, newborns and children, pregnant women and overall was 33% (95% CI, 29.0–38.0%), 42.0% (95 CI, 34.0–49.0%), 32.0% (CI, 26.0–38.0%), 42.0% (CI, 38.0–45.0%), 4.0% (CI, 2.0–5.0%), 40.0% (CI,37.0–44.0%), and 36% (CI, 24.0–48.0%), respectively. Conclusion: The results of our umbrella review show a higher seroprevalence of T. gondii infection in immunocompromised patients, general population, pregnant women, blood donors, childbearing age women, and newborn groups, respectively. Routine serologic screening test and health education by primary care physicians for Toxoplasmosis is recommended to be conducted in high-risk groups in the endemic region.

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“…T. gondii remains dormant in infected tissues and may reactivate in immunocompromised individuals, leading to potentially fatal complications [10,11]. HIV patients and hematopoietic stem cell and heart transplant recipients are more susceptible to T. gondii infection [12].…”

Section: Introductionmentioning

confidence: 99%

Serological and molecular rapid diagnostic tests for Toxoplasma infection in humans and animals

Khan

Noordin

2019

Eur J Clin Microbiol Infect Dis

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Infection by Toxoplasma gondii is prevalent worldwide. The parasite can infect a broad spectrum of vertebrate hosts, but infection of fetuses and immunocompromised patients is of particular concern. Easy-to-perform, robust, and highly sensitive and specific methods to detect Toxoplasma infection are important for the treatment and management of patients. Rapid diagnostic methods that do not sacrifice the accuracy of the assay and give reproducible results in a short time are highly desirable. In this context, rapid diagnostic tests (RDTs), especially with point-of-care (POC) features, are promising diagnostic methods in clinical microbiology laboratories, especially in areas with minimal laboratory facilities. More advanced methods using microfluidics and sensor technology will be the future trend. In this review, we discuss serological and molecular-based rapid diagnostic tests for detecting Toxoplasma infection in humans as well as animals.

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Toxoplasmosis seroprevalence in rheumatoid arthritis patients: A systematic review and meta-analysis

Cited by 43 publications

References 41 publications

A systematic review and meta-analysis of the genetic characterization of human echinococcosis in Iran, an endemic country

A systematic review and meta-analysis of the genetic characterization of human echinococcosis in Iran, an endemic country

Seroprevalence of toxoplasma gondii infection: An umbrella review of updated systematic reviews and meta-analyses

Serological and molecular rapid diagnostic tests for Toxoplasma infection in humans and animals

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