Tp-e/QT ratio as an index of arrhythmogenesis

Gupta, Prasad; Patel, Chinmay; Patel, Harsh; Narayanaswamy, Srinivasa; Malhotra, Binu; Green, Jared T.; Yan, Gan‐Xin

doi:10.1016/j.jelectrocard.2008.07.016

Cited by 515 publications

(541 citation statements)

References 46 publications

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“…T p T e dispersion, T p T e /QT ratio and T p T e /QTc ratio are also used as an electrocardiographic index of ventricular arrhythmogenesis 12,21. Sicouri et al found a relationship between ventricular arrhythmia and prolonged T p T e interval 22…”

Section: Discussionmentioning

confidence: 99%

“…T peak –T end (T p T e ) interval is defined as the interval between the peak point and endpoint of the T wave on surface electrocardiography and is a novel index of transmural dispersion of ventricular repolarisation 10. T p T e /QT ratio and T p T e /QT c ratio were used in previous studies as an electrocardiographic index in the evaluation of risk of ventricular arrhythmia 11,12…”

Section: Introductionmentioning

confidence: 99%

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Carbon monoxide poisoning increases Tpeak-Tend dispersion and QTc dispersion : cardiovascular topic

Eroğlu¹,

Uz²,

Işılak³

et al. 2014

CVJA

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SummaryObjectiveCarbon monoxide (CO) poisoning leads to cardiac dysrhythmia. Increased heterogeneity in ventricular repolarisation on electrocardiogram (ECG) shows an increased risk of arrhythmia. A number of parameters are used to evaluate ventricular repolarisation heterogeneity on ECG. The aim of our study is to investigate the effect of acute CO poisoning on indirect parameters of ventricular repolarisation on ECG.MethodsSixty-seven patients were included in this case–control study. Thirty patients with acute CO poisoning were assigned to group 1 (19 females, mean age: 30.8 ± 11.3 years). A control group was formed with patients without known cardiac disease (group 2, n = 37; 25 females, mean age: 26.0 ± 5.2 years). Twelve-lead ECG and serum electrolyte levels were recorded in all patients. Also, carboxyhaemoglobin (COHb) levels were recorded in group 1. Tpeak–Tend (TpTe) interval, TpTe dispersion, TpTe/QT ratio, QT interval and QTd durations were measured as parameters of ventricular repolarisation. Corrected QT (QTc) and QTc dispersion (QTcd) intervals were determined with the Bazett’s formula.ResultsThe mean COHb level in group 1 was 27.6 ± 7.4% and mean duration of CO exposure was 163.5 ± 110.9 min. No statistically significant difference was found in age, gender, serum electrolytes or blood pressure levels between the groups. QRS, QT, QTc, TpTe interval and TpTe/QT ratio were similar between the groups (p > 0.05). QTcd (65.7 ± 64.4 vs 42.1 ± 14.2 ms, p = 0.003) and TpTe dispersion (40.5 ± 14.8 vs 33.2 ± 4.9 ms, p = 0.006) were significantly longer in group 1 than group 2. COHb level was moderately correlated with TpTe dispersion (r = 0.29; p = 0.01).ConclusionTo our knowledge, this is the first study to investigate TpTe interval and dispersion in CO poisoning. Our results showed that TpTe dispersion and QTc dispersion increased after CO poisoning.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Carbon monoxide poisoning increases Tpeak-Tend dispersion and QTc dispersion : cardiovascular topic

Eroğlu¹,

Uz²,

Işılak³

et al. 2014

CVJA

View full text Add to dashboard Cite

show abstract

“…It has been shown that the QT interval lengthened and QTd increased after sympathetic system activity or catecholamine discharge [28]. The Tp-e interval and Tp-e/QT ratio have been used as indices of ventricular repolarization to predict ventricular arrhythmias and sudden cardiac death [13][14][15][16][17]. Several investigators have studied repolarization patterns in patients with SCF and have shown that QTd, Tp-e interval and Tp-e/QT ratio were increased compared to controls [11,29].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Tp-e might be a predictor of ventricular tachycardias and cardiovascular mortality [14,15]. However, changes in body weight and heart rate affect the Tp-e interval [16]. To address this issue, the Tp-e/QT ratio was suggested as a more accurate measure for the dispersion of ventricular repolarization compared to QTd, corrected QTd, and Tp-e intervals, and to be independent of alterations in heart rate [16,17].…”

Section: The Relationship Between Ventricular Repolarization Indexesmentioning

confidence: 99%

“…However, changes in body weight and heart rate affect the Tp-e interval [16]. To address this issue, the Tp-e/QT ratio was suggested as a more accurate measure for the dispersion of ventricular repolarization compared to QTd, corrected QTd, and Tp-e intervals, and to be independent of alterations in heart rate [16,17]. The total white blood cell (WBC) count and its subtypes, such as neutrophil, lymphocyte, and neutrophil/lymphocyte ratio (NLR), can be used as an indicator of systemic inflammation [18].…”

Section: The Relationship Between Ventricular Repolarization Indexesmentioning

confidence: 99%

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The Relationship between Ventricular Repolarization Indexes and Neutrophil to Lymphocyte Ratio in Patients with Slow Coronary Flow

Suner¹,

Yaşar²

2016

Ann Clin Lab Res

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Cardiac Corrected QT Interval Changes Among Patients Treated for COVID-19 Infection During the Early Phase of the Pandemic

et al. 2021

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IMPORTANCECritical illness, a marked inflammatory response, and viruses such as SARS-CoV-2 may prolong corrected QT interval (QTc). OBJECTIVE To evaluate baseline QTc interval on 12-lead electrocardiograms (ECGs) and ensuing changes among patients with and without COVID-19. DESIGN, SETTING, AND PARTICIPANTS This cohort study included 3050 patients aged 18 years and older who underwent SARS-CoV-2 testing and had ECGs at Columbia University Irving Medical Center from March 1 through May 1, 2020. Patients were analyzed by treatment group over 5 days, as follows: hydroxychloroquine with azithromycin, hydroxychloroquine alone, azithromycin alone, and neither hydroxychloroquine nor azithromycin. ECGs were manually analyzed by electrophysiologists masked to COVID-19 status. Multivariable modeling evaluated clinical associations with QTc prolongation from baseline. EXPOSURES COVID-19, hydroxychloroquine, azithromycin. MAIN OUTCOMES AND MEASURES Mean QTc prolongation, percentage of patients with QTc of 500 milliseconds or greater.RESULTS A total of 965 patients had more than 2 ECGs and were included in the study, with 561 (58.1%) men, 198 (26.2%) Black patients, and 191 (19.8%) aged 80 years and older. There were 733 patients (76.0%) with COVID-19 and 232 patients (24.0%) without COVID-19. COVID-19 infection was associated with significant mean QTc prolongation from baseline by both 5-day and 2-day multivariable models 15.29 to 26.33] milliseconds;

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Tp-e/QT ratio as an index of arrhythmogenesis

Cited by 515 publications

References 46 publications

Carbon monoxide poisoning increases Tpeak-Tend dispersion and QTc dispersion : cardiovascular topic

Carbon monoxide poisoning increases Tpeak-Tend dispersion and QTc dispersion : cardiovascular topic

The Relationship between Ventricular Repolarization Indexes and Neutrophil to Lymphocyte Ratio in Patients with Slow Coronary Flow

Cardiac Corrected QT Interval Changes Among Patients Treated for COVID-19 Infection During the Early Phase of the Pandemic

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