TP53 codon 72 polymorphism in 12 populations of insular Southeast Asia and Oceania

Kashima, Taeko; Makino, Kumiko; Soemantri, Augustinua; Ishida, Takafumi

doi:10.1007/s10038-007-0168-8

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…The highly significant tumor suppressor gene, TP53, is implicated in a wide range of human cancers, including brain tumors (Biros et al, 2002). P53 is a multifunctional protein that plays central roles in cellular responses to DNA damage, cellular senescence and apoptosis to maintain genomic stability of a cell (Kashima et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors

Almeida

Custódio²,

Pinto³

et al. 2009

Genet. Mol. Res.

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AbSTRACT. The p53 tumor suppressor gene is the most frequently mutated gene in human cancer; this gene is mutated in up to 50% of human tumors. It has a critical role in the cell cycle, apoptosis and cell senescence, and it participates in many crucial physiological and pathological processes. Polymorphisms of p53 have been suggested to be associated with genetically determined susceptibility in various types of cancer. Another process involved with the Aberrant methylation of the promoter is an alternative epigenetic change in genetic mechanisms, leading to tumor suppressor gene inactivation. In the present study, we examined the TP53 Arg72Pro and Pro47Ser polymorphisms using PCR-RFLP and the pattern of methylation of the p53 gene by methylation-specific PCR in 90 extra-axial brain tumor samples. Patients who had the allele Pro of the TP53 Arg72Pro polymorphism had an increased risk of tumor development (odds ratio, OR = 3.23; confidence interval at 95%, 95%CI = 1.71-6.08; P = 0.003), as did the allele Ser of TP53 Pro47Ser polymorphism (OR = 1.28; 95%CI = 0.03-2.10; P = 0.01).Comparison of overall survival of patients did not show significant differences. In the analysis of DNA methylation, we observed that 37.5% of meningiomas, 30% of schwannomas and 52.6% of metastases were hypermethylated, suggesting that methylation is important for tumor progression. We suggest that TP53 Pro47Ser and Arg72Pro polymorphisms and DNA hypermethylation are involved in susceptibility for developing extra-axial brain tumors.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors

Almeida

Custódio²,

Pinto³

et al. 2009

Genet. Mol. Res.

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“…The Arg72 allele frequency among all samples of the Mandarese Austronesian-speaking ethnic group members was 0.44. A previous study revealed that the Arg72 allele frequencies among the two largest ethnic groups in South Sulawesi (Torajans and Buginese) from locations near West Sulawesi were 0.45 and 0.55, respectively [19]. Based on those findings, it can be postulated that the historical backgrounds of the Takandeang, Salleto, and Ahu village inhabitants were potentially closer to the Torajans than to the Buginese.…”

Section: Distribution Of the Tp53 Polymorphism (Rs1042522) In Takandementioning

confidence: 89%

Molecular and <em>in silico</em> Study of TP53 Codon 72 Polymorphism (rs1042522) in a Population Exposed to High Background Radiation in Mamuju-West Sulawesi

et al. 2020

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“…It was reported that the allele distribution at codon 72 of TP53 varies depending on geographical locations (44,45). Therefore, to clarify the association between codon 72 polymorphism and the glioma risk in different genetic backgrounds and remove heterogeneity, we analyzed the collected data by subgrouping the high-grade glioma group according to the geographical locations.…”

Section: Discussionmentioning

confidence: 99%

TP53 codon 72 polymorphism and glioma risk: A meta-analysis

et al. 2011

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Abstract. TP53 codon 72 polymorphism has been reported to affect regulatory networks central to glioma development. Although a number of published studies noted the association between TP53 codon 72 polymorphism and glioma risk, their conclusions were inconsistent. A meta-analysis was used to assess the possible association between TP53 codon 72 polymorphism and glioma risk. The PubMed databases were searched, relevant articles were identified and data were retrieved based on the inclusion criteria. The odds ratio (OR) and 95% confidence interval (95% CI) were determined on the pooled dataset. We retrieved eight different studies including 2,260 glioma cases and 3,506 controls. However, no association was found between the TP53 codon 72 polymorphism and glioma risk regarding the comparison between glioma cases and the controls. By further stratification based on criteria such as tumor grade, and the geographical location of the patients and the relevant controls, we found a significant association in the subgroup of patients with high-grade glioma in Europeans compared to controls in two models of TP53 codon 72 polymorphism, which include the dominant model [C/C + G/C vs. G/G: OR=1.35, 95% CI (1.14, 1.59), P=0.0005, P h =0.13] and the additive model [C allele vs. G allele: OR=1.16, 95% CI (1.02, 1.33), P=0.03, P h =0.37]. Our analysis suggests that TP53 codon 72 polymorphism is associated with an increased risk of high-grade glioma development in Europeans.

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TP53 codon 72 polymorphism in 12 populations of insular Southeast Asia and Oceania

Cited by 10 publications

References 19 publications

Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors

Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors

Molecular and <em>in silico</em> Study of TP53 Codon 72 Polymorphism (rs1042522) in a Population Exposed to High Background Radiation in Mamuju-West Sulawesi

TP53 codon 72 polymorphism and glioma risk: A meta-analysis

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