TP53 Codon 72 Polymorphisms and Lung Cancer Risk in the Bangladeshi Population

Chowdhury, Miraj Kobad; Moniruzzaman, Md.; Emran, Abdullah Al; Mostafa, Mohammad Golam; Kuddus, Ruhul; Uddin, Md. Aftab

doi:10.7314/apjcp.2015.16.8.3493

Cited by 10 publications

(8 citation statements)

References 30 publications

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“…A total of 12 case-control studies were included in this meta-analysis to find out the association of TP53 codon 72 Arg/Pro polymorphism with lung cancer and breast cancer in the South Asian population based on the inclusion criteria (Shabnaz et al, 2016;Hashemi et al, 2018;Aziz et al, 2013;Suresh et al, 2011;Syeed et al, 2010;Ihsan et al, 2011;Tilak et al, 2013;Chowdhury et al, 2015;Mostaid et al, 2014;Saikia et al, 2014;Sharma et al, 2014). Among these, six studies evaluated the association for breast cancer (950 cases and 882 controls) and the other six studies for lung cancer (975 cases and 1,397 controls).…”

Section: Study Characteristicsmentioning

confidence: 99%

Association of TP53 Codon 72 Arg>Pro Polymorphism with Breast and Lung Cancer Risk in the South Asian Population: A Meta-Analysis

Jafrin

Aziz

Anonna

et al. 2020

Asian Pac J Cancer Prev

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Background: A transversion missense polymorphism of the TP53 tumor suppressor gene at the codon 72 codes proline instead of arginine causes an altered p53 protein expression and has been found to be associated with an elevated risk of various cancer; especially breast and lung cancer. As the previous case-control studies on the South Asian population have shown controversial results, we performed a meta-analysis to evaluate a precise estimation of the relationship between the TP53 Arg72Pro polymorphism with breast and lung cancer. Methods: A total of 12 related studies on the South Asian population have been included through comprehensive database searching. Six studies were selected for breast cancer meta-analysis involving 950 cases and 882 controls; the other six studies were for lung cancer meta-analysis including 975 cases and 1397 controls. The results have been determined by using the Review Manager (RevMan) 5.3. Additionally, the stability of our analysis was assessed by heterogeneity, publication bias analysis and sensitivity testing. Results: A significantly increased risk of breast cancer was found in Pro allele (Pro vs. Arg), co-dominant model 2 (Pro/Pro vs. Arg/Arg), dominant model (Pro/Pro + Arg/Pro vs. Arg/Arg). In case of lung cancer, significantly increased risk was found in the allele, co-dominant 1, co-dominant 2, co-dominant 3, dominant, and recessive models. No association with other genetic models with breast and lung cancer risk was found in the South Asian population. Conclusions: Our results indicate that TP53 Arg72Pro polymorphism is a risk factor for the development of breast cancer and lung cancer in the South Asian population.

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Section: Study Characteristicsmentioning

confidence: 99%

Association of TP53 Codon 72 Arg>Pro Polymorphism with Breast and Lung Cancer Risk in the South Asian Population: A Meta-Analysis

Jafrin

Aziz

Anonna

et al. 2020

Asian Pac J Cancer Prev

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“…They found that rs1042522 C>G polymorphism conferred higher susceptibility to thyroid cancer [39]. In a study conducted among the Bangladeshi population including 50 histopatho-logically confirmed lung cancer patients and 50 age-matched controls, Chowdhury et al found that the TP53 gene rs1042522 CC genotype is a risk factor for lung cancer [40]. Wu et al .…”

Section: Discussionmentioning

confidence: 99%

The TP53 gene rs1042522 C>G polymorphism and neuroblastoma risk in Chinese children

Wang

Zhu

et al. 2017

Aging

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TP53, a tumor suppressor gene, plays a critical role in cell cycle control, apoptosis, and DNA damage repair. Previous studies have indicated that the TP53 gene Arg72Pro (rs1042522 C>G) polymorphism is associated with susceptibility to various types of cancer. We evaluated the association of the TP53 gene rs1042522 C>G polymorphism with neuroblastoma susceptibility in a hospital-based study among the Chinese Han population. Enrolled were 256 patients and 531 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) generated using logistic regression models were used to determine the strength of the association of interest. No association was detected between rs1042522 C>G polymorphism and neuroblastoma risk. In our stratification analysis of age, gender, sites of origin, and clinical stages, we observed that subjects with rs1042522 CG/GG genotypes had a lower risk of developing neuroblastoma in the mediastinum (Adjusted OR=0.52, 95% CI=0.33-0.82, P=0.005) than those carrying the CC genotype. These results indicate that TP53 gene rs1042522 C>G polymorphism may exert a weak and site-specific effect on neuroblastoma risk in Southern Chinese children and warrant further confirmation.

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“…Cai et al have reported that smokers with Pro/Pro genotype had a 2.00-fold increased risk of hepatocellular carcinoma in a Chinese population when compared with non-smoking individuals with Arg/Arg genotype (26). In a population in Bangladesh, it has been reported that TP53Pro allele as a risk factor for lung cancer overrepresented among smokers compared to controls (OR = 1.8 -10.0, P ≤ 0.01 -0.03) (27). On the other hand, a significant interaction has been reported between TP53 Pro/Pro genetic polymorphism and smoking in esophageal squamous cell carcinoma (OR = 5.29, 95% CI = 2.91 -9.61) (28).…”

Section: Discussionmentioning

confidence: 99%

TP53 Codon 72 Genetic Polymorphism, rs1042522, Modifies the Association Between Tobacco Smoking and Breast Cancer Risk

Moradinasab

Ostovar

Nabipour

et al. 2017

Iran Red Crescent Med J

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Background: TP53 tumor suppressor gene participates in several pathways involving in carcinogenesis such as cell cycle control, DNA repair, and apoptosis. A common TP53 SNP (guanine/cytosine nucleotide substitution at codon 72), rs1042522, affects the function of p53 protein and may influence tumor behavior in response to environmental carcinogens. Objectives: This study investigates the association between TP53 codon 72 polymorphisms, tobacco smoking, and breast cancer risk in southern Iranian women from Bushehr. Methods: A case-control study was conducted on 144 cases with histologically confirmed invasive breast carcinoma and 162 randomly selected healthy controls with no previous cancer history in their family. TP53 codon 72 genotype was determined by using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique. Results: Analysis revealed that smoking frequency was significantly higher in cases compared to controls (OR = 2.31, 95%CI = 1.33-3.99, P = 0.003) and the association between smoking and breast cancer was only significant for individuals with Arg/Pro genotype (OR = 3.23, 95% CI = 1.47 -7.06, P = 0.003). On the other hand, there was no statistically considerable difference in the allele and genotype distribution between cases and controls. Conclusions: These results should be confirmed in larger studies, but suggest that TP53 Arg/Pro genotype modifies the risk of breast cancer in tobacco smokers and causes significantly more susceptibility to breast cancer due to smoking.

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TP53 Codon 72 Polymorphisms and Lung Cancer Risk in the Bangladeshi Population

Cited by 10 publications

References 30 publications

Association of TP53 Codon 72 Arg>Pro Polymorphism with Breast and Lung Cancer Risk in the South Asian Population: A Meta-Analysis

Association of TP53 Codon 72 Arg>Pro Polymorphism with Breast and Lung Cancer Risk in the South Asian Population: A Meta-Analysis

The TP53 gene rs1042522 C>G polymorphism and neuroblastoma risk in Chinese children

TP53 Codon 72 Genetic Polymorphism, rs1042522, Modifies the Association Between Tobacco Smoking and Breast Cancer Risk

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