TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Squamous cell carcinoma of the oral cavity (OSCC) is the most common head-andneck malignancy. Importantly, we are experiencing an alarming rise in the incidence of oropharyngeal squamous cell carcinoma (OPSCC) globally. Oncogenic viruses, human papillomavirus (HPV) and Epstein-Barr virus (EBV), are known to be co-associated with OSCC and OPSCC cases. However, the reported incidence of HPV and EBV coinfection in OSCCs and OPSCCs globally is unknown. To address this, we performed a formal meta-analysis and systematic review on published studies that report the detection of both EBV and HPV in OSCCs and OPSCCs. Our analysis revealed 18 relevant studies out of a total of 1820 cases (1181 from the oral cavity and 639 from the oropharynx). Overall, HPV and EBV co-infection was found in 11.9% of OSCC and OPSCC cases combined (95% CI: 8%-14.1%). Based on anatomical subsite, dual positivity estimates were 10.5% (95% CI: 6.7%-15.1%) for OSCC and 14.2% (95% CI: 9.1%-21.3%) for OPSCC. The highest dual positivity rates described were in European countries: for OSCC 34.7% (95% CI: 25.9%-44.6%) in Sweden and for OPSCC, 23.4% (95% CI: 16.9%-31.5%) in Poland. Given these substantive prevalence rates, the value of detecting dual infection in the diagnosis and prognosis of these cancers deserves careful longitudinal studies, as do implications for cancer prevention and therapy. We further proposed molecular mechanisms that could explain how HPV and EBV could co-contribute to the aetiology of OSCCs and OPSCCs.

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“…Two articles incorrectly recorded samples of OSCC in OPSCC, namely Jarzynski et al. (2017) and Polz‐Gruszka, Morshed, Jarzyński, et al. (2015).…”

Section: Resultsmentioning

confidence: 99%

Human papillomavirus and Epstein‐Barr virus co‐infection in oral and oropharyngeal squamous cell carcinomas: A systematic review and meta‐analysis

Rahman

Shaikh

Gopinath

et al. 2023

Molecular Oral Microbiology

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“…An increased frequency of TP53 promoter methylation was evidenced in HR-HPV/EBV-infected OPSCCs compared to HR-HPV or EBV infection alone [ 222 ]. Additionally, HPV/EBV coinfection was associated with the E-cadherin gene (CDH1) and RB1 promoter methylation in cervical lesions [ 223 ].…”

Section: Possible Mechanisms Of Hr-hpv/ebv Cooperationmentioning

confidence: 99%

High-Risk Human Papillomavirus and Epstein–Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis

Blanco

Carrillo-Beltrán

Corvalán

et al. 2021

Biology

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High-risk human papillomaviruses (HR-HPVs) and Epstein–Barr virus (EBV) are recognized oncogenic viruses involved in the development of a subset of head and neck cancers (HNCs). HR-HPVs are etiologically associated with a subset of oropharyngeal carcinomas (OPCs), whereas EBV is a recognized etiological agent of undifferentiated nasopharyngeal carcinomas (NPCs). In this review, we address epidemiological and mechanistic evidence regarding a potential cooperation between HR-HPV and EBV for HNC development. Considering that: (1) both HR-HPV and EBV infections require cofactors for carcinogenesis; and (2) both oropharyngeal and oral epithelium can be directly exposed to carcinogens, such as alcohol or tobacco smoke, we hypothesize possible interaction mechanisms. The epidemiological and experimental evidence suggests that HR-HPV/EBV cooperation for developing a subset of HNCs is plausible and warrants further investigation.

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TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Cited by 2 publications

References 16 publications

Human papillomavirus and Epstein‐Barr virus co‐infection in oral and oropharyngeal squamous cell carcinomas: A systematic review and meta‐analysis

Human papillomavirus and Epstein‐Barr virus co‐infection in oral and oropharyngeal squamous cell carcinomas: A systematic review and meta‐analysis

High-Risk Human Papillomavirus and Epstein–Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis

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