TP53 rs1042522 and rs8064946 variants in myocardial infarction

Abstract

OBJECTIVE: This study investigated the hypothesis that the single nucleotide polymorphisms (SNPs) of TP53 gene are related to a risk of myocardial infarction. METHODS: The coding SNP at codon 72 (rs1042522) and non-coding rs8064946 SNP were genotyped by polymerase chain reaction with sequence specifi c primers in 205 Czech patients with myocardial infarction and 148 Czech control subjects. RESULTS: The distribution of both SNPs was in agreement with the Hardy-Weinberg equilibrium and was similar to other European populations. Our power analysis showed 96 % of probability to detect an odd ratio equal to 2. Neither rs1042522 nor rs8064946 were associated with the risk of myocardial infarction. The haplotypes combined of rs1042522 and rs8064946 were not associated with myocardial infarction in the present study. CONCLUSION: The TP53 SNPs are not strongly associated with genetic predisposition to myocardial infarction

Identification and Interaction Analysis of Molecular Markers in Myocardial Infarction by Integrated Bioinformatics Analysis

“…The subsequent construction of the miRNA-hub gene regulatory network and TF- hub gene regulatory network using the respective hub gens identified miRNA and TFs as potential key markers involved in MI. Chen et al [222], Li and Zhang [223], Wang et al [224], Zhao et al [225], Lin et al [226], Liao et al [227], Izadpanah et al [228], Wang et al [229] and Hakobjanyan et al [230] reported that the expression of the hsa-mir-409-3p, hsa-mir-320d, hsa-mir-107, hsa-mir-139-5p, NRF1, TEAD1, GATA2, E2F1 and TP53 are correlated with disease grades of MI. hsa-mir-301a-5p [231], hsa-mir-29a-5p [232], hsa-mir-296-5p [233], CREB1 [234] and FOXA1 [235] were linked with progression of diabetes mellitus, but these genes might be novel target for MI.…”