TP63 Gene Polymorphisms, Cooking Oil Fume Exposure and Risk of Lung Adenocarcinoma in Chinese Non-smoking Females

Yin, Zhihua; Cui, Zhigang; Ren, Yong; Su, Meng; Ma, Rui; He, Qincheng; Zhou, Baosen

doi:10.7314/apjcp.2013.14.11.6519

Cited by 14 publications

(13 citation statements)

References 29 publications

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“…In our previous published papers, cooking oil fume exposure was found to be significantly associated with the risk of lung cancer in non-smoking females [14–18], so in the present study we analyze the interaction between SNPs and cooking oil fume exposure. For cooking oil fume exposure, participants were asked about the frequency of cooking and types of oils.…”

Section: Methodsmentioning

confidence: 99%

“…Our previous reports showed that household exposure to cooking oil fume was associated with the risk of non-smoking female lung cancer [14–18]. A study in a high incidence population in North East India found that the interaction of XRCC1Gln/Gln genotype with exposure of exposure of cooking oil fumes was significantly associated with increased risk for lung cancer [19].…”

Section: Introductionmentioning

confidence: 99%

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Interaction between Polymorphisms in Pre-MiRNA Genes and Cooking Oil Fume Exposure on the Risk of Lung Cancer in Chinese Non-Smoking Female Population

et al. 2015

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BackgroundBoth genetic polymorphisms and environmental risk factors play important roles in the development of human chronic diseases including lung cancer. This is the first case-control study of interaction between polymorphisms in pre-miRNA genes and cooking oil fume exposure on the risk of lung cancer.MethodsA hospital-based case-control study of 258 cases and 310 controls was conducted. Six polymorphisms in miRNAs were determined by Taqman allelic discrimination method. The gene-environment interactions were assessed on both additive and multiplicative scale. The statistical analyses were performed mostly with SPSS.ResultsThe combination of the risk genotypes of five miRNA SNPs (miR-146a rs2910164, miR-196a2 rs11614913, miR-608 rs4919510, miR-27a rs895819 and miR-423 rs6505162) with risk factor (cooking oil fume exposure) contributed to a significantly higher risk of lung cancer, and the corresponding ORs (95% confidence intervals) were 1.91(1.04-3.52), 1.94 (1.16-3.25), 2.06 (1.22-3.49), 1.76 (1.03-2.98) and 2.13 (1.29-3.51). The individuals with both risk genotypes of miRNA SNPs and exposure to risk factor (cooking oil fumes) were in a higher risk of lung cancer than persons with only one of the two risk factors (ORs were 1.91, 1.05 and 1.41 for miR-146a rs2910164, ORs were 1.94, 1.23 and 1.34 for miR-196a2 rs11614913, ORs were 2.06, 1.41 and 1.68 for miR-608 rs4919510, ORs were 1.76, 0.82 and 1.07 for miR-27a rs895819, and ORs were 2.13, 1.15 and 1.02 for miR-423 rs6505162, respectively). All the measures of biological interaction indicate that there were not indeed biological interactions between the six SNPs of miRNAs and exposure to cooking oil fumes on an additive scale. Logistic models suggested that the gene-environment interactions were not statistically significant on a multiplicative scale.ConclusionsThe interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interaction between Polymorphisms in Pre-MiRNA Genes and Cooking Oil Fume Exposure on the Risk of Lung Cancer in Chinese Non-Smoking Female Population

et al. 2015

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“…Exposure to welding fumes at work place (Mannetje et al, 2012), cooking fumes (Yin et al, 2013), sedentary living (Yang et al, 2003), family history (Cote et al, 2012), exposure to wood dust (Bhatti et al, 2011), alcoholism (Bagnardi et al, 2010) and asbestos exposure (Markowitz et al, 2013) has also been reported in Caucasian, American, African and Asian populations as positive risk factors of lung cancer. But high OR value of 2.5 in Pakistani population for welding fumes in present study is higher than any other parts of the world.…”

Section: Causative Factorsmentioning

confidence: 99%

Risk Factors for Lung Cancer in the Pakistani Population

Luqman¹,

Javed²,

Daud³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Lung cancer is one of the most prevalent malignancies in the world and both incidence and mortality rates are continuing to rise in Pakistan. However, epidemiological studies to identify common lung cancer determinants in the Pakistani population have been limited. Materials and Methods: In this retrospective case-control study, 400 cases and 800 controls were enrolled from different hospitals of all provinces of Pakistan. Information about socio-demographic, occupational, lifestyle and dietary variables was extracted by questionnaire from all subjects. Odd ratios (ORs) and 95% confidence intervals (CIs) were calculated. and dose-response associations were also assessed for suitable factors.

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“…Exposure to cooking oil fumes might increase the risk of lung adenocarcinoma in Chinese nonsmoking females (adjusted OR=1.58, 95%CI=1.11-2.25, P=0.011). However, significant interaction of cooking oil fumes and TP63 polymorphisms was not observed [43]. Cao et al [44] demonstrated decreased cell viability, increased malondialdehyde (MDA) level, decreased superoxide dismutase (SOD) and glutathione (GSH) activities in a doseand time-dependent manner of CFs, which proved CFs may lead to toxicity in AEC II cells at a very low dose.…”

Section: B Cooking Fumes Effects On the Cellmentioning

confidence: 99%

Cooking Fumes and Relative Diseases

Wang¹,

Liu²,

He³

2017

Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)

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Abstract-Cooking fumes are mixture of various toxic components such as aldehydes, heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs), fat aerosols and particulate matters (PM), which are mainly produced during or after cooking. Due to the toxic contents of CFs, CFs might cause lung toxicity, immune toxicity, hereditary toxicity, potential carcinogenicity and so on to organism. There were several studies investigated the toxicity impact of CFs. However, comprehensive review about the production, composition harm to the contacts and reduction methods of CFs is still lacking. In this review, the production, composition and effects on the contacts of cooking fumes were presented. In addition, reduction methods of cooking fumes were also presented. This review would provide references for the avoidance of CFs relative disease and the comprehensive disposal of CFs.

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TP63 Gene Polymorphisms, Cooking Oil Fume Exposure and Risk of Lung Adenocarcinoma in Chinese Non-smoking Females

Cited by 14 publications

References 29 publications

Interaction between Polymorphisms in Pre-MiRNA Genes and Cooking Oil Fume Exposure on the Risk of Lung Cancer in Chinese Non-Smoking Female Population

Interaction between Polymorphisms in Pre-MiRNA Genes and Cooking Oil Fume Exposure on the Risk of Lung Cancer in Chinese Non-Smoking Female Population

Risk Factors for Lung Cancer in the Pakistani Population

Cooking Fumes and Relative Diseases

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