tPA Receptors and the Fibrinolytic Response in Multiple Sclerosis Lesions

Gverić, Djordje; Herrera, Blanca; Cuzner, M. L.

doi:10.1016/s0002-9440(10)62334-6

Cited by 25 publications

(21 citation statements)

References 53 publications

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“…tPA is a critical element in shaping the complex and fundamental roles of astrocytes in the control of the brain homeostasis. The demonstration shown here of tPA sorting between neurons and astrocytes suggests critical roles for tPA in diseases of the CNS, such as ischemic brain injuries, head and spinal trauma, and multiple sclerosis (Gveric et al, 2005). Also, uptake of tPA by astrocytes may influence physiological processes that involve tPA, such as those related to learning and memory , anxiety (Pawlak et al, 2003), and addiction (Nagai et al, 2004).…”

Section: Discussionmentioning

confidence: 75%

Glutamate Controls tPA Recycling by Astrocytes, Which in Turn Influences Glutamatergic Signals

Cassé¹,

Bardou²,

Danglot³

et al. 2012

J. Neurosci.

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Tissue-type plasminogen activator (tPA) regulates physiological processes in the brain, such as learning and memory, and plays a critical role in neuronal survival and neuroinflammation in pathological conditions. Here we demonstrate, by combining mouse in vitro and in vivo data, that tPA is an important element of the cross talk between neurons and astrocytes. The data show that tPA released by neurons is constitutively endocytosed by astrocytes via the low-density lipoprotein-related protein receptor, and is then exocytosed in a regulated manner. The exocytotic recycling of tPA by astrocytes is inhibited in the presence of extracellular glutamate. Kainate receptors of astrocytes act as sensors of extracellular glutamate and, via a signaling pathway involving protein kinase C, modulate the exocytosis of tPA. Further, by thus capturing extracellular tPA, astrocytes serve to reduce NMDA-mediated responses potentiated by tPA. Overall, this work provides the first demonstration that the neuromodulator, tPA, may also be considered as a gliotransmitter.

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Section: Discussionmentioning

confidence: 75%

Glutamate Controls tPA Recycling by Astrocytes, Which in Turn Influences Glutamatergic Signals

Cassé¹,

Bardou²,

Danglot³

et al. 2012

J. Neurosci.

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“…ANXA2 is a calcium and phospholipid-binding protein. Several molecules known to bind to ANXA2 affect a number of physiologically and pathologically important functions [Brownstein et al, 2004;Gveric et al, 2005]. It has been found to be up-regulated in liver cancer [Mohammad et al, 2008].…”

Section: Anxa2 Was Found To Be Related To Liver Fibrosismentioning

confidence: 99%

Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis

Zhang

Xia

Zhang

et al. 2010

J of Cellular Biochemistry

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It is important to study the mechanism of liver fibrogenesis, and find new non-invasive biomarkers. In this study, we used subcellular proteomic technology to study the plasma membrane (PM) proteins related to immune liver fibrosis and search for new non-invasive biomarkers. A rat liver fibrosis model was induced by pig serum injection. The liver fibrogenesis from stage (S) S0-1, S2, S3-4, and S4 was detected by Masson staining and HE staining in this rat model after 2, 4, 6, and 8 weeks of treatment. The liver PM was enriched and analyzed using subcellular proteomic technology. The differentially expressed proteins were verified by Western blotting, immunohistochemistry, and ELISA. PM with 149-fold purification was obtained and 22 differentially expressed proteins were identified. Of which, annexin A2 (ANXA2) was detected to be increased obviously in S4 compared with S0-1, and verified by Western blotting of rat liver tissue and immunohistochemistry of rat and human liver tissue. The expression of ANXA2 in human plasma with S1-2 was also found to be up-regulated for 1.4-fold than that in S0. Furthermore, ANXA2 was detected to translocate from nuclear membrane and cytosol to PM as HBV stimulation through immunocytochemical analysis in vitro. This study identified 22 differentially expressed proteins related to liver fibrosis, and verified a potential biomarker (ANXA2) for non-invasive diagnosis of immune liver fibrosis. To our knowledge, it was the first time to dynamically study the proteins related to liver fibrosis and select biomarkers for liver fibrosis diagnosis through PM proteome research.

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“…ANXA2 is a calcium and phospholipid binding protein. Several molecules are known to bind to ANXA2 affecting a number of physiologically and pathologically important functions [5][6][7][8]. ANXA2 is involved in the plasminogen/plasmin system as a receptor for tissue plasminogen activator (tPA), plasminogen (PLG) and plasmin (PN).…”

Section: Introductionmentioning

confidence: 99%

Direct effects of alcohol on hepatic fibrinolytic balance: Implications for alcoholic liver disease

Seth

Hogg

Gorrell

et al. 2008

Journal of Hepatology

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tPA Receptors and the Fibrinolytic Response in Multiple Sclerosis Lesions

Abstract: Axonal damage in multiple sclerosis (MS) lesions is

Cited by 25 publications

References 53 publications

Glutamate Controls tPA Recycling by Astrocytes, Which in Turn Influences Glutamatergic Signals

Glutamate Controls tPA Recycling by Astrocytes, Which in Turn Influences Glutamatergic Signals

Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis

Direct effects of alcohol on hepatic fibrinolytic balance: Implications for alcoholic liver disease

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