“…TPH-2 has been widely debated as a major candidate gene in numerous psychiatric disorders including MDD, anxiety, schizophrenia, and bipolar disorder ( Zill et al, 2004 ). Numerous candidate TPH-2 variants, namely rs4290270 ( Shen et al, 2011 ; Wang et al, 2015 ; Karanovic et al, 2017 ; Mei et al, 2018 ), rs4570625 ( Gao et al, 2012 ; Mandelli et al, 2012 ; Lehto et al, 2015 ; Han et al, 2017 ; Piel et al, 2018 ; Wigner et al, 2018 ), rs41317118 ( Xu et al, 2013 ), rs11178998 ( Xu et al, 2016 ; Ottenhof et al, 2018 ), rs7305115 ( Ke et al, 2006 ; Van der Auwera et al, 2014 ; Wang et al, 2015 ; Ottenhof et al, 2018 ), rs17110747 ( Tsai et al, 2009 ; Ottenhof et al, 2018 ), rs10748185 ( Serretti et al, 2011 ; Ottenhof et al, 2018 ), rs18438099 ( Anttila et al, 2009 ; Ottenhof et al, 2018 ), rs11316791, rs1386493, rs1386494 ( Haghighi et al, 2008 ), have been prominently associated with MDD. The exonal variants, rs7305115 and rs4290270, were prominently associated with MDD and disturbed sleep ( Utge, 2012 ; Mei et al, 2018 ).…”