2016
DOI: 10.1093/ijnp/pyw070
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TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs

Abstract: Background:Variation in genes implicated in monoamine neurotransmission may interact with environmental factors to influence antidepressant response. We aimed to determine how a range of single nucleotide polymorphisms in monoaminergic genes influence this response to treatment and how they interact with childhood trauma and recent life stress in a Chinese sample. An initial study of monoaminergic coding region single nucleotide polymorphisms identified significant associations of TPH2 and HTR1B single nucleot… Show more

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Cited by 25 publications
(13 citation statements)
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“…TPH-2 has been widely debated as a major candidate gene in numerous psychiatric disorders including MDD, anxiety, schizophrenia, and bipolar disorder ( Zill et al, 2004 ). Numerous candidate TPH-2 variants, namely rs4290270 ( Shen et al, 2011 ; Wang et al, 2015 ; Karanovic et al, 2017 ; Mei et al, 2018 ), rs4570625 ( Gao et al, 2012 ; Mandelli et al, 2012 ; Lehto et al, 2015 ; Han et al, 2017 ; Piel et al, 2018 ; Wigner et al, 2018 ), rs41317118 ( Xu et al, 2013 ), rs11178998 ( Xu et al, 2016 ; Ottenhof et al, 2018 ), rs7305115 ( Ke et al, 2006 ; Van der Auwera et al, 2014 ; Wang et al, 2015 ; Ottenhof et al, 2018 ), rs17110747 ( Tsai et al, 2009 ; Ottenhof et al, 2018 ), rs10748185 ( Serretti et al, 2011 ; Ottenhof et al, 2018 ), rs18438099 ( Anttila et al, 2009 ; Ottenhof et al, 2018 ), rs11316791, rs1386493, rs1386494 ( Haghighi et al, 2008 ), have been prominently associated with MDD. The exonal variants, rs7305115 and rs4290270, were prominently associated with MDD and disturbed sleep ( Utge, 2012 ; Mei et al, 2018 ).…”
Section: Introductionmentioning
confidence: 99%
“…TPH-2 has been widely debated as a major candidate gene in numerous psychiatric disorders including MDD, anxiety, schizophrenia, and bipolar disorder ( Zill et al, 2004 ). Numerous candidate TPH-2 variants, namely rs4290270 ( Shen et al, 2011 ; Wang et al, 2015 ; Karanovic et al, 2017 ; Mei et al, 2018 ), rs4570625 ( Gao et al, 2012 ; Mandelli et al, 2012 ; Lehto et al, 2015 ; Han et al, 2017 ; Piel et al, 2018 ; Wigner et al, 2018 ), rs41317118 ( Xu et al, 2013 ), rs11178998 ( Xu et al, 2016 ; Ottenhof et al, 2018 ), rs7305115 ( Ke et al, 2006 ; Van der Auwera et al, 2014 ; Wang et al, 2015 ; Ottenhof et al, 2018 ), rs17110747 ( Tsai et al, 2009 ; Ottenhof et al, 2018 ), rs10748185 ( Serretti et al, 2011 ; Ottenhof et al, 2018 ), rs18438099 ( Anttila et al, 2009 ; Ottenhof et al, 2018 ), rs11316791, rs1386493, rs1386494 ( Haghighi et al, 2008 ), have been prominently associated with MDD. The exonal variants, rs7305115 and rs4290270, were prominently associated with MDD and disturbed sleep ( Utge, 2012 ; Mei et al, 2018 ).…”
Section: Introductionmentioning
confidence: 99%
“…The promoter region of the TPH2 gene lacks a CpG island; however, there are numerous scattered CpG sites and an enriched signal of DNA hypomethylation at the 5′-UTR locus ( Chen and Miller, 2012 ). A recent study has shown that hypermethylation of the CpG-site in the TPH2 gene during early-life stress could reduce antidepressant response within the first 2 weeks of treatment in patients with MDD ( Xu et al, 2016 ; Shen et al, 2020 ). Furthermore, methylation of a single CpG site in the promoter region of TPH2 significantly decreases TPH2 gene expression levels.…”
Section: Early Life Social Stress-induced Epigenetic Changes In Serotmentioning
confidence: 99%
“…В проведенных ранее исследованиях были показаны влияние полиморфизма гена TPH2 на развитие большого депрессивного расстройства (БДР), суицидального поведения, обсессивно-компульсивного расстройства, а также его связь с синдромом дефицита внимания и гиперактивности (СДВГ) [8][9][10][11]. Также при психотических расстройствах отмечена зависимость между полиморфизмом гена TPH2 и ответом на лечение антидепрессантами из группы ингибиторов обратного захвата серотонина [12][13][14]. Данных о связи полиморфизма гена ТРН2 с ожирением в научной литературе в настоящее время нет.…”
Section: обоснованиеunclassified