“…In fact, it has been shown that these models are able to reproduce the normal architecture of bone. The studies [4,5,9,10,21,22] are examples of bidimensional simulations, while in [16,18,23,24] 3D results are found. These models have also been used to predict the osteoporosis process [25] as well as effects related to the resorption phenomenon in host bone due to orthopedic implants [3,6,8,11,[26][27][28][29].…”