Trabecular bone modulus–density relationships depend on anatomic site

Morgan, Elise F.; Bayraktar, Harun H.; Keaveny, Tony M.

doi:10.1016/s0021-9290(03)00071-x

Cited by 1,001 publications

(784 citation statements)

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“…Current finite element approaches use empirical methods (Morgan et al 2003) to define isotropic mechanical behaviour based on observed bone mineral density values derived from the grey values in µCT scans. The multiscale model developed herein has shown that tissue behaviour is highly anisotropic and dependant on factors other than bone mineral density.…”

Section: Discussionmentioning

confidence: 99%

A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone

Vaughan

McCarthy

McNamara

2012

Journal of the Mechanical Behavior of Biomedical Materials

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Section: Discussionmentioning

confidence: 99%

A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone

Vaughan

McCarthy

McNamara

2012

Journal of the Mechanical Behavior of Biomedical Materials

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“…Falling is a dynamic event involving high strain rates. Material properties of bone tissue are not only volume fraction dependent and anisotropic (Helgason et al, 2008;Morgan et al, 2003), but are also visco-elastic and visco-plastic (i.e. stiffer and stronger, but more brittle) under impact-compared to quasi-static loading conditions (Carter and Hayes, 1977).…”

Section: Introductionmentioning

confidence: 99%

Nonlinear quasi-static finite element simulations predict in vitro strength of human proximal femora assessed in a dynamic sideways fall setup

Варга

Schwiedrzik

Zysset

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Nonlinear quasi-static finite element simulations predict in vitro strength of human proximal femora assessed in a dynamic sideways fall setup, Journal of the Mechanical Behavior of Biomedical Materials, http://dx.doi. org/10.1016/j.jmbbm.2015.11.026 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. was negligible for all predictions. These results suggest that quasi-static homogenized finite element analysis may be used to predict mechanical properties of proximal femora in the dynamic sideways fall situation.

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“…Factors such as porosity, mineralization, collagen fibre orientation, diameter and spacing and other aspects of histological structure strongly affect mechanical properties; have positive effect on crack initiation and negative influence on their growth [4]. The effect of bone quantity on the mechanical behaviour and structural integrity of bone was established previously [5,6], however, more in-depth investigations are still required of the contributory effects of microstructure, material properties, and microcrack propagation [3,7]. These can be characterized as bone quality measures; an improved understanding of bone quality, particularly, resistance to crack initiation and propagation can help in accessing bone fracture risk [8].…”

Section: Introductionmentioning

confidence: 99%

Micro-scale modelling of bovine cortical bone fracture: Analysis of crack propagation and microstructure using X-FEM

Abdel-Wahab

Maligno

Silberschmidt

2012

Computational Materials Science

124

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• This is the author's version of a work that was accepted for publication in Computational Materials Science.Changes resulting from the publishing process, such as peer review, editing, corrections, structural for- Micro-scale modelling of bovine cortical bone fracture: Analysis of crack propagation and microstructure using X-FEM Adel A. Abdel-Wahab, Angelo R. Maligno, and Vadim V. SilberschmidtWolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK Abstract Bone fracture susceptibility increased by factors such as bone loss, microstructure changes, and material properties variations. Therefore, investigation of the microstructure and material properties effect on the crack propagation and the global response at macro-scale level is of great importance. A non-uniform distribution of osteons in a cortical bone tissue results in a localization of deformation processes. Such localization can affect bone performance under external load and initiate fracture or assist its propagation. Once the fracture initiates, that distribution can play an important role on the crack propagation process at micro-scale level. Subsequently, the global response at macro-scale level could also be affected. In this study, a two-dimensional numerical (finite-element) fracture model for osteonal bovine cortical bone was developed with account for its microstructure using X-FEM. The topology of a transverse-radial cross section of a bovine cortical bone was captured with optical microscopy. The mechanical properties for the microstructural features of the cross-section were obtained with a use of the nanoindentation technique. Both the topology and nanoindentation data were used as input to the model formulated with the Abaqus 6.10 finite-element software. The area, directly reflecting micro-scale information, was embedded into the region with homogenised properties of the cortical bone. The simulations provide the macro-scale global response, crack propagation paths and the distribution of maximum principal stress fields at the micro-scale level for three different microscopic topologies; homogeneous, two phase composite model and threr phase composite model under tensile loading condition. The calculated stress fields for various cases of topologies demonstrate different patterns due to implementation of microstructural features in the finite-element model. There is an important role of the microstructure on the crack propagation trajectory. The suggested approach emphasizes the importance of microstructural features, especially cement lines, in development of bone failure.

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Trabecular bone modulus–density relationships depend on anatomic site

Cited by 1,001 publications

References 44 publications

A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone

A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone

Nonlinear quasi-static finite element simulations predict in vitro strength of human proximal femora assessed in a dynamic sideways fall setup

Micro-scale modelling of bovine cortical bone fracture: Analysis of crack propagation and microstructure using X-FEM

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