Trabecular Bone Structure of the Calcaneus: Comparison of MR Imaging at 3.0 and 1.5 T with Micro-CT as the Standard of Reference

Phan, Carole; Matsuura, Maiko; Bauer, Jan; Dunn, Timothy; Newitt, David C.; Lochmueller, Eva M; Eckstein, F.; Majumdar, Sharmila; Link, Thomas M.

doi:10.1148/radiol.2392050574

Cited by 99 publications

(74 citation statements)

References 35 publications

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“…Trabecular structural parameters measured with 3.0 T are better defined than those at 1.5 T using micro-CT as a reference standard. Although correlations between 3.0 T and microCT are better than 1.5 T, increased trabecular broadening has been observed at 3.0 T due to an increase in susceptibility effect [36] . High correlation has been found also for trabecular number and spacing by comparing 3.0 T MR and high resolution pQCT.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 92%

“…A magnetic susceptibility difference of about 3 ppm existing between bone and marrow leads to signal dampening at the bonemarrow interface and, as a result, an artificial overestimation of trabecular dimension occurs. This artefact, known as trabecular broadening, is responsible for an apparent increase in trabecular thickness that vary with pulse sequence applied and field strength [36] . MR pulse sequence strongly affects MR susceptibility artefact but it is not clear yet which pulse sequence is the best for trabecular bone imaging [37,38] .…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

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Fractal lacunarity of trabecular bone and magnetic resonance imaging: New perspectives for osteoporotic fracture risk assessment

Alimazighi¹

2015

WJO

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Osteoporosis represents one major health condition for our growing elderly population. It accounts for severe morbidity and increased mortality in postmenopausal women and it is becoming an emerging health concern even in aging men. Screening of the population at risk for bone degeneration and treatment assessment of osteoporotic patients to prevent bone fragility fractures represent useful tools to improve quality of life in the elderly and to lighten the related socio-economic impact. Bone mineral density (BMD) estimate by means of dualenergy X-ray absorptiometry is normally used in clinical practice for osteoporosis diagnosis. Nevertheless, BMD alone does not represent a good predictor of fracture risk. From a clinical point of view, bone microarchitecture seems to be an intriguing aspect to characterize bone alteration patterns in aging and pathology. The widening into clinical practice of medical imaging techniques and the impressive advances in information technologies together with enhanced capacity of power calculation have promoted proliferation of new methods to assess changes of trabecular bone architecture (TBA) during aging and osteoporosis. Magnetic resonance imaging (MRI) has recently arisen as a useful tool to measure bone structure in vivo . In particular, high-resolution MRI techniques have introduced new perspectives for TBA characterization by non-invasive non-ionizing methods. However, texture analysis methods have not found favor with clinicians as they produce quite a few parameters whose interpretation is difficult. The introduction in biomedical field of paradigms, such as theory of complexity, chaos, and fractals, suggests new approaches and provides innovative tools to develop computerized methods that, by producing a limited number of parameters sensitive to pathology onset and progression, would speed up their application into clinical practice. Complexity of living beings and fractality of several physio-anatomic structures suggest fractal analysis as a promising approach to quantify morphofunctional changes in both aging and pathology. In this particular context, fractal lacunarity seems to be the proper tool to characterize TBA texture as it is able to describe both discontinuity of bone network and sizes of bone marrow spaces, whose changes are an index of bone fracture risk. In this paper, an original method of MRI texture analysis, based on TBA fractal lacunarity is described and discussed in the light of new perspectives for early diagnosis of osteoporotic fractures.

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Section: Magnetic Resonance Imagingmentioning

confidence: 92%

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Fractal lacunarity of trabecular bone and magnetic resonance imaging: New perspectives for osteoporotic fracture risk assessment

Alimazighi¹

2015

WJO

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“…This can be problematic in adolescents going through puberty at different times, because the timing of the growth spurt of puberty in these teenagers is variable. This is of particular importance in girls with AN in whom puberty is stalled or delayed and also because prolonged undernutrition can potentially lead to impaired statural growth.Researchers in several studies have used CT and magnetic resonance imaging to assess and analyze trabecular structure in vivo (10,16,20,(38)(39)(40)(41). Use of the distal radius for structure analysis has proved valuable in the prediction of vertebral fractures (20).…”

mentioning

confidence: 99%

Distal Radius in Adolescent Girls with Anorexia Nervosa: Trabecular Structure Analysis with High-Resolution Flat-Panel Volume CT

Bredella

Misra²,

Miller³

et al. 2008

Radiology

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Purpose:To examine trabecular microarchitecture with high-resolution flat-panel volume computed tomography (CT) and bone mineral density (BMD) with dual-energy x-ray absorptiometry (DXA) in adolescent girls with anorexia nervosa (AN) and to compare these results with those in normal-weight control subjects. Materials and Methods:The study was approved by the institutional review board and complied with HIPAA guidelines. Informed consent was obtained. Twenty adolescent girls, 10 with mild AN (mean age, 15.9 years; range, 13-18 years) and 10 ageand sex-matched normal-weight control subjects (mean age, 15.9 years; range, 12-18 years) underwent flat-panel volume CT of distal radius to determine apparent trabecular bone volume fraction (BV/TV), apparent trabecular number (TbN), apparent trabecular thickness (TbTh), and apparent trabecular separation (TbSp). All subjects underwent DXA of spine, hip, and whole body to determine BMD and body composition. The means and standard deviations (SDs) of structure parameters were calculated for AN and control groups. Groups were compared (Student t test). Linear regression analysis was performed. Results:AN subjects compared with control subjects, respectively, showed significantly lower mean values for BV/TV (0.37% Ϯ 0.05 [SD] vs 0.46% Ϯ 0.03, P ϭ .0002) and TbTh (0.31 mm Ϯ 0.03 vs 0.39 mm Ϯ 0.03, P Ͻ .0001) and higher mean values for TbSp (0.54 mm Ϯ 0.13 vs 0.44 mm Ϯ 0.04, P ϭ .02). TbN was lower in AN subjects than in control subjects, but the difference was not significant (1.17 mm Ϫ3 Ϯ 0.15 vs 1.22 mm Ϫ3 Ϯ 0.07, P ϭ .43). There was no significant difference in BMD between AN and control subjects. BMD parameters showed positive correlation with BV/TV and TbTh in the control group (r ϭ 0.55-0.84, P ϭ .05-.01) but not in AN patients. Conclusion:Flat-panel volume CT is effective in evaluation of trabecular structure in adolescent girls with AN and demonstrates that bone structure is abnormal in these patients compared with that in normal-weight control subjects despite normal BMD. RSNA, 2008 Note: This copy is for your personal, non-commercial use only. To order presentation-ready copies for distribution to your colleagues or clients, use the Radiology Reprints form at the end of this article. Low bone mineral density (BMD) is a serious complication of anorexia nervosa (AN) in adults and adolescents (1,2). Decreased bone mass occurs in multiple skeletal sites and is associated with a sevenfold increased fracture risk that may persist despite recovery (3,4). The onset of AN during the adolescent years is of particular concern because this is a crucial time for bone mass accrual toward achievement of peak bone mass. Deficits in the normal rate of bone mass accrual during this period can result in low peak bone mass and an increased risk of fractures in adult life (2,5). Dual-energy x-ray absorptiometry (DXA) is commonly used for the assessment of BMD; however, it is highly influenced by body size (6), which provides a diagnostic challenge in children with AN, because prolon...

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“…Different imaging modalities with various analysis techniques have been successfully applied in both in vitro and clinical in vivo settings to characterize bone geometry and internal structure (5)(6)(7)(8)(9)(10). Trabecular bone architecture is generally described by morphological parameters, such as bone volume/total volume (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), and trabecular number (Tb.N) (11,12).…”

mentioning

confidence: 99%

MRI texture analysis of femoral neck: Detection of exercise load‐associated differences in trabecular bone

Harrison

Nikander

Sikiö

et al. 2011

Magnetic Resonance Imaging

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Purpose: To assess the ability of co-occurrence matrix-based texture parameters to detect exercise load-associated differences in MRI texture at the femoral neck cross-section. Materials and Methods:A total of 91 top-level female athletes representing five differently loading sports and 20 referents participated in this cross-sectional study. Axial T1-weighted FLASH and T2*-weighted MEDIC sequence images of the proximal femur were obtained with a 1.5T MRI. The femoral neck trabecular bone at the level of the insertion of articular capsule was divided manually into regions of interest representing four anatomical sectors (anterior, posterior, superior, and inferior). Selected co-occurrence matrix-based texture parameters were used to evaluate differences in apparent trabecular structure between the exercise loading groups and anatomical sectors of the femoral neck.Results: Significant differences in the trabecular bone texture, particularly at the superior femoral neck, were observed between athletes representing odd-impact (soccer and squash) and high-magnitude exercise loading (powerlifting) groups and the nonathletic reference group.Conclusion: MRI texture analysis provides a quantitative method for detecting and classifying apparent structural differences in trabecular bone that are associated with specific exercise loading.

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Trabecular Bone Structure of the Calcaneus: Comparison of MR Imaging at 3.0 and 1.5 T with Micro-CT as the Standard of Reference

Abstract: MR imaging at 3.0 T provided a better measure of the trabecular bone structure than did MR imaging at 1.5 T. There was a trend for better differentiation of donors with from those without osteoporotic vertebral fractures at 3.0 T than at 1.5 T.

Cited by 99 publications

References 35 publications

Fractal lacunarity of trabecular bone and magnetic resonance imaging: New perspectives for osteoporotic fracture risk assessment

Fractal lacunarity of trabecular bone and magnetic resonance imaging: New perspectives for osteoporotic fracture risk assessment

Distal Radius in Adolescent Girls with Anorexia Nervosa: Trabecular Structure Analysis with High-Resolution Flat-Panel Volume CT

MRI texture analysis of femoral neck: Detection of exercise load‐associated differences in trabecular bone

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