Trabeculectomy bleb-associated infections

Purpose: To compare the efficacy and safety of collagen matrix implant (Ologen â ; OLO) with mitomycin C (MMC) in phacotrabeculectomy. Methods: Prospective, single-centre, nonblinded, randomized controlled trial. A total of 53 eyes of 45 patients were enrolled in the study protocol with 27 eyes randomly assigned to OLO and 26 to MMC. The follow-up was 12 months. The primary outcome measure was mean change from baseline intraocular pressure (IOP) in both groups after 12 months. The secondary outcome measures were cumulative success rates at 12 months with Kaplan-Meier analysis, change in number of medications, change in best corrected visual acuity (BCVA), and bleb morphology assessed using Moorfields Bleb Grading System and anterior segment swept-source optical coherence tomography. Results: The mean IOP decreased from 26.4 AE 6.1 mmHg to 13.7 AE 3.8 in the OLO group and from 23.4 AE 3.6 mmHg to 13.3 AE 2.8 in the MMC group at 1 year without significant intergroup differences. At 1 year, the overall success rates were 92.6% and 92.3% in the OLO and MMC groups, respectively. There were no significant differences in the overall success rates, BCVA, number of medications, morphology of the filtering blebs and rate of complications at the end of the follow-up. Conclusion: Ologen (OLO) provides similar surgical outcomes in phacotrabeculectomy compared with adjunctive MMC. It may be a new, safe and effective alternative to MMC for combined phacoemulsification and trabeculectomy surgery.

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“…blebitis and endophthalmitis (Razeghinejad et al. ). Moreover, antimetabolites may cause long‐term problems, like endothelial cell loss.…”

Section: Introductionmentioning

confidence: 99%

Phacotrabeculectomy using collagen matrix implant (Ologen^®) versus mitomycin C: a prospective randomized controlled trial

Właź

Rozegnał-Madej

Żarnowski

2019

Acta Ophthalmologica

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“…Major surgical factors are posterior capsular rupture poor corneal wound construction and other inadequate wound closure leading to hypotony [ 50 , 56 – 60 ]. As for systemic risk factors, patients with diabetes mellitus are more likely to be infected after surgeries [ 50 , 53 , 58 , 61 ]. As for microbiology, the most prevalent organisms of culture-positive postcataract endophthalmitis are the gram-positive organisms, and 70% of gram-positive bacteria are coagulase-negative Staphylococcus [ 62 – 64 ].…”

Section: Discussionmentioning

confidence: 99%

Research Trends and Hotspot Analysis of Conjunctival Bacteria Based on CiteSpace Software

Wang

Huang

2020

BioMed Research International

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Objective. To sort out the literature related to conjunctival bacteria and summarize research hotspots and trends of this field. Materials and Methods. The relevant literature data from 1900 to 2019 was retrieved from the Web of Science Core Collection database. After manual selection, each document record includes title, author, keywords, abstract, year, organization, and citation. We imported the downloaded data into CiteSpace V (version 5.5R2) to draw the knowledge map and conduct cooperative network analysis, discipline and journal analysis, cluster analysis, and burst keyword analysis. Results. After manual screening, there were 285 relevant papers published in the last 28 years (from 1991 to 2019), and the number is increasing year by year. The publications of conjunctival bacteria were dedicated by 1381 authors of 451 institutions in 56 countries/regions. The United States dominates this field (82 literatures), followed by Germany (23 literatures) and Japan (23 literatures). Overall, most cited papers were published with a focus on molecular biology, genetics, nursing, and toxicology. Most papers fall into the category of ophthalmology, veterinary sciences, and pharmacology and pharmacy. The only organized cluster is the “postantibiotic effect,” and the top 5 keywords with the strongest citation bursts include “postoperative endophthalmiti(s),” “infectious keratoconjunctiviti(s),” “conjunctiviti(s),” “resistance,” and “diversity”. Conclusion. The global field of conjunctival bacteria has expanded in the last 28 years. The United States contributes most. However, there are little cooperation among authors and institutions. Overall, this bibliometric study organized one cluster, “postantibiotic effect”, and identified the top 5 hotspots in conjunctival bacteria research: “postoperative endophthalmiti(s),” “infectious keratoconjunctiviti(s),” “conjunctiviti(s),” “resistance,” and “diversity”. Thus, further research focuses on these topics that may be more helpful to prevent ocular infection and improve prophylaxis strategies to bring a benefit to patients in the near future.

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“…Trabeculectomy bleb-associated infections are a serious and vision-threatening complication whose incidence varies among different studies; however, there is cumulative evidence that the incidence of bleb-associated infections has reduced over time [43]. The Collaborative Initial Glaucoma Treatment Study (CIGTS) found a 5-year risk of blebitis and bleb-associated endophthalmitis of 1.5% and 1.1%, respectively, after trabeculectomy [44].…”

Section: Infectionmentioning

confidence: 99%

EX-PRESS Glaucoma Filtration Device: Management of Complications

Nicolai

Franceschi

Pelliccioni

et al. 2020

Vision

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The EX-PRESS glaucoma filtration device appears to be an effective addition to our options to treat refractory glaucoma. The possibility to create a sclerostomy without tissue excision provides a safe and reliable outflow pathway for aqueous that is standard in size, reducing much of the variability associated with a surgical procedure. Prospective randomized studies comparing EX-PRESS implantation with trabeculectomy show encouraging results. However, complications usually encountered in filtration surgery have been reported, and EX-PRESS implantation can also lead to specific device-related complications. This article reviews the most common complications associated with this procedure.

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Trabeculectomy bleb-associated infections

Cited by 53 publications

References 193 publications

Phacotrabeculectomy using collagen matrix implant (Ologen^®) versus mitomycin C: a prospective randomized controlled trial

Phacotrabeculectomy using collagen matrix implant (Ologen^®) versus mitomycin C: a prospective randomized controlled trial

Research Trends and Hotspot Analysis of Conjunctival Bacteria Based on CiteSpace Software

EX-PRESS Glaucoma Filtration Device: Management of Complications

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Trabeculectomy bleb-associated infections

Cited by 53 publications

References 193 publications

Phacotrabeculectomy using collagen matrix implant (Ologen®) versus mitomycin C: a prospective randomized controlled trial

Phacotrabeculectomy using collagen matrix implant (Ologen®) versus mitomycin C: a prospective randomized controlled trial

Research Trends and Hotspot Analysis of Conjunctival Bacteria Based on CiteSpace Software

EX-PRESS Glaucoma Filtration Device: Management of Complications

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Product

Resources

About

Phacotrabeculectomy using collagen matrix implant (Ologen^®) versus mitomycin C: a prospective randomized controlled trial

Phacotrabeculectomy using collagen matrix implant (Ologen^®) versus mitomycin C: a prospective randomized controlled trial