Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma

Leon, John Mark de; Azarbod, Parham; Chen, Andrew; Morales, Esteban; Nouri‐Mahdavi, Kouros; Coleman, Anne L.; Yu, Fei; Afifi, Abdelmonem A.

doi:10.1016/j.ophtha.2015.09.027

Cited by 87 publications

(66 citation statements)

References 47 publications

(22 reference statements)

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“…In eyes with progressive normal tension glaucoma, Iverson et al 7 and Shigeeda et al 8 reported mean postoperative MD change of −0.25 dB/year and −0.44 dB/year respectively, compared with −1.05 dB/year preoperatively in both cohorts. In a recent study by Caprioli et al ,10 the mean decay rate (measured by the VF index) in patients who underwent trabeculectomy slowed from −2.4±9.3%/year preoperatively to −0.6±13.1% after surgery.…”

Section: Discussionmentioning

confidence: 90%

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Rates of glaucomatous visual field change after trabeculectomy

et al. 2016

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Section: Discussionmentioning

confidence: 90%

“…In order to avoid the possibility of a regression to the mean effect, we compared our rates of progression post surgery with a control group matched by baseline MD and composed of patients who were treated medically, without ever having glaucoma surgery. A similar approach was used by Caprioli et al 10 in a recently published manuscript.…”

Section: Discussionmentioning

confidence: 99%

Rates of glaucomatous visual field change after trabeculectomy

et al. 2016

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“…Second, we focused on IOP reduction but not on restoration or improved visual function. A recent study by Caprioli et al indicated that trabeculectomy might reverse the glaucomatous dysfunction of retinal ganglion cells and their central projections [44].…”

Section: Discussionmentioning

confidence: 99%

Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study

Dang¹,

Wang²,

Cen³

et al. 2018

Preprint

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To evaluate the 2-year efficacy and safety of ab interno trabeculectomy with the Trabectome in Chinese primary open-angle glaucoma (POAG) patients. This was a multicenter, retrospective study and included POAG patients with or without visually-significant cataracts. The primary outcome was intraocular pressure (IOP) reduction. Secondary outcomes included reduction of glaucoma medications, surgical complications, and success at 2-years. Success was defined as: 1) IOP < 21 mmHg and at least 20% IOP reduction from baseline after 3 months at any two consecutive visits, and 2) no additional glaucoma surgery required. A total of 42 patients were enrolled; thirteen had a history of failed glaucoma surgery. Twelve patients underwent Trabectome surgery combined with phacoemulsification while the remainder underwent Trabectome surgery alone. Overall, the mean preoperative IOP was 21.4±1.23 mmHg. The Trabectome lowered IOP to 18.5± 0.94 mmHg at 2 years (P<0.05). The number of glaucoma medications also decreased from a baseline of 2.0±0.9 to 1.2± 0.21 at 2 years (P=0.04). The overall success was 78%, with patients undergoing combined surgery having a higher success than those with Trabectome surgery alone (100% vs. 76%). No major complications were seen. The Trabectome appears to be an efficient and safe procedure in Chinese POAG patients in the longterm.

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“…The ultimate goal is to slow or stop structural and functional progression while maintaining or enhancing overall quality of life. Some recent evidence also suggests that VF improvement may be achieved with IOP lowering [77]. The treating ophthalmologists should strive to maintain the IOP in a stable range to prevent further damage of the optic nerve [78].…”

Section: Treatment Goalsmentioning

confidence: 99%

Medical Management of Glaucoma in the 21st Century from a Canadian Perspective

Harasymowycz

Birt

Gooi

et al. 2016

Journal of Ophthalmology

100

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Glaucoma is a medical term describing a group of progressive optic neuropathies characterized by degeneration of retinal ganglion cells and retinal nerve fibre layer and resulting in changes in the optic nerve head. Glaucoma is a leading cause of irreversible vision loss worldwide. With the aging population it is expected that the prevalence of glaucoma will continue to increase. Despite recent advances in imaging and visual field testing techniques that allow establishment of earlier diagnosis and treatment initiation, significant numbers of glaucoma patients are undiagnosed and present late in the course of their disease. This can lead to irreversible vision loss, reduced quality of life, and a higher socioeconomic burden. Selection of therapeutic approaches for glaucoma should be based on careful ocular examination, patient medical history, presence of comorbidities, and awareness of concomitant systemic therapies. Therapy should also be individualized to patients' needs and preferences. Recent developments in this therapeutic field require revisiting treatment algorithms and integration of traditional and novel approaches in order to ensure optimal visual outcomes. This article provides an overview of recent developments and practice trends in the medical management of glaucoma in Canada. A discussion of the surgical management is beyond the scope of this paper.

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Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma

Cited by 87 publications

References 47 publications

Rates of glaucomatous visual field change after trabeculectomy

Rates of glaucomatous visual field change after trabeculectomy

Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study

Medical Management of Glaucoma in the 21st Century from a Canadian Perspective

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