Trace elements in human tissue. 1. A semi-quantitative spectrographic survey

Stitch, S. R.

doi:10.1042/bj0670097

Cited by 69 publications

(24 citation statements)

References 14 publications

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“…The comparison of our results with published data for Br, Fe, Rb, Sr, and Zn mass fraction in normal and cancerous prostate tissue [32][33][34][35][36][37][38][39][40][41][42][43][44] is shown in Table 3.…”

Section: Resultsmentioning

confidence: 81%

Trace Element Contents in Adenocarcinoma of Human Prostate Investigated by Energy Dispersive X-Ray Fluorescent Analysis

Zaichick¹,

Zaichick²

2016

J Adenocarcinoma

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Background: Adenocarcinoma of prostate is an internationally important health problem of the man, particularly in developed countries. The aim of this exploratory study was to evaluate whether significant changes in the prostatic tissue levels of Zn, as an androgen dependent trace element and Br, Fe, Rb, and Sr, as androgen independent trace elements, exist in the malignantly transformed prostate. Methods and findings:Prostatic tissue levels of Br, Fe, Rb, Sr, and Zn as well as ratio of Zn content to other trace element contents were prospectively evaluated in 35 patients with adenocarcinoma and 37 healthy male inhabitants. Measurements were performed using 109 Cd radionuclide-induced energy dispersive X-ray fluorescent analysis Tissue samples were divided into two portions. One was used for morphological study while the other was intended for trace element analysis. Mean values ± standard error of means (M ± SΕΜ) for mass fraction (mg/kg on dry mass basis) of trace element in the normal tissue was: Br 38.8 ± 5.6, Fe 118 ± 8, Rb 16.3 ± 1.1, Sr 2.5 ± 0.4, and Zn 1154 ± 119, respectively. M ± SΕΜ for ratio of mass fractions were: Zn/Br 38.7 ± 6.4, Zn/Fe 11.2 ± 1.3, Zn/Rb 71.7 ± 9.0 and Zn/Sr 534 ± 83, respectively. The contents of Rb and Zn were significantly lower (approximately 2 and 8 times, respectively) and those of Br and Sr was significantly higher (2.7 and 2.2 times, respectively) in cancerous tissues than in normal tissues. Conclusions:There are great changes in trace element contents and their relationships in the malignantly transformed tissue of prostate.

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Section: Resultsmentioning

confidence: 81%

Trace Element Contents in Adenocarcinoma of Human Prostate Investigated by Energy Dispersive X-Ray Fluorescent Analysis

Zaichick¹,

Zaichick²

2016

J Adenocarcinoma

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“…This indicates that Al accumulates in the body during continuous intake, even in subjects with normal renal function. Brain, bone, liver and serum Al concentrations increase with age (Stitch 1957;Zapatero et al 1995;Markesbery et al 1984;Roider and Drasch 1999;Shimizu et al 1994;Hellström et al 2005). …”

Section: Distributionmentioning

confidence: 99%

Aluminum in Food – The Nature and Contribution of Food Additives

Yokel¹

2012

Food Additive

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“…In earlier reported studies [31]- [64] significant changes of some trace element contents in hyperplastic and cancerous prostate in comparison with those in the normal prostatic tissue were observed. Moreover, a significant informative value of Zn content as a tumor marker for PCa diagnostics was shown by us [65] [66].…”

Section: Introductionmentioning

confidence: 99%

Trace Element Levels in Prostate Gland as Carcinoma’s Markers

Zaichick¹,

Zaichick²

2017

JCT

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Objectives: The aim of this study was to evaluate the changes in the prostatic levels of trace elements in the malignant human prostate. Methods: Contents of 43 trace elements in normal (N, n = 37), benign hypertrophic (BPH, n = 32) and cancerous (PCa, n = 60) prostate were investigated. Measurements were performed using instrumental neutron activation analysis and inductively coupled plasma mass spectrometry. Results: The mass fractions of all trace elements with the exception of La, Nb, and Yb show significant variations in cancerous prostate when compared with normal and BPH prostate. The contents of Co, Hg, Rb, Sc, Se, and Zn were significantly lower and those of Ag, Al, Au, B, Be, Bi, Br, Ce, Cr, Cs, Dy, Er, Gd, Ho, Li, Mn, Mo, Nd, Ni, Pb, Pr, Sb, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, Y, Yb, and Zr were significantly higher in PCa than in BPH tissues. When trace elements of cancerous prostate were compared with those in normal prostatic parenchyma, contents of Cd, Rb, Sc, Se, and Zn were significantly lower and Ag, Al, Au, B, Be, Bi, Br, Ce, Cr, Dy, Er, Fe, Gd, Hg, Ho, Li, Mn, Nd, Ni, Pr, Sb, Sm, Sn, Tb, Th, Tl, Y, and Zr were significantly higher. Conclusion: The Ag, Al, B, Br, Li, Mn, Ni, and Zn mass fraction in a needle-biopsy core can be used as the informative indicators for distinguishing malignant from benign prostate. Sensitivity, specificity, and accuracy of these tests were in range 72% -100%, 66% -100%, and 74% -98%, respectively.

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Trace elements in human tissue. 1. A semi-quantitative spectrographic survey

Cited by 69 publications

References 14 publications

Trace Element Contents in Adenocarcinoma of Human Prostate Investigated by Energy Dispersive X-Ray Fluorescent Analysis

Trace Element Contents in Adenocarcinoma of Human Prostate Investigated by Energy Dispersive X-Ray Fluorescent Analysis

Aluminum in Food – The Nature and Contribution of Food Additives

Trace Element Levels in Prostate Gland as Carcinoma’s Markers

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