Trace Elements in Normal and Impaired Wound Healing

Söderberg, Thor A.

doi:10.1007/978-3-642-77882-7_16

Cited by 5 publications

(6 citation statements)

References 57 publications

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“…Its beneficial effect was firstly described by Strain and coworkers, 18 who observed an acceleration of healing in burned rats fed with a zinc‐enriched diet. This result has been confirmed, in vitro and in vivo , by many studies 17 . 19 For many years, zinc oxide‐containing ointments and pastes have been used for the treatment of wounds in humans and animals.…”

Section: Discussionsupporting

confidence: 64%

“…2 Zinc seems to be a very important trace element in wound healing. 17 Its bene®cial eect was ®rstly described by Strain and coworkers, 18 who observed an acceleration of healing in burned rats fed with a zinc-enriched diet. This result has been con®rmed, in vitro and in vivo, by many studies.…”

Section: Discussionmentioning

confidence: 97%

“…This result has been con®rmed, in vitro and in vivo, by many studies. 17,19 For many years, zinc oxide-containing ointments and pastes have been used for the treatment of wounds in humans and animals. A standardized formulation of zinc oxide and cod liver oil ointment used in Germany showed signi®cant bene®cial eects in a wound healing model in mice.…”

Section: Discussionmentioning

confidence: 99%

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Improvement and retardation of wound healing: effects of pharmacological agents in laboratory animal studies

Kietzmann

1999

Veterinary Dermatology

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Impaired wound healing is an important problem; retardation of healing may be induced by endogenous and/or exogenous factors and treatments capable of ameliorating these eects are needed. The eects of solutions containing light ichthyol or povidone iodine, of ointments containing zinc oxide (ZO) and/ or cod liver oil (CLO), and of a polyurethane-hydrogel foam wound dressing were examined on healing of full-thickness murine skin wounds impaired by systemic dexamethasone. The eects of the ointments were also studied on murine skin ulceration induced by subcutaneous sodium dodecyl sulphate solution. Light ichthyol at 1% and 2% but not at 5% and 10%, povidone iodine at 1% and the foam accelerated impaired healing. The ointments containing ZO or CLO accelerated healing of impaired full-thickness wounds and of ulcerated skin; ZO and CLO were synergistic. These studies demonstrate the value of murine models in the evaluation of agents employed in veterinary wound dressings.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Improvement and retardation of wound healing: effects of pharmacological agents in laboratory animal studies

Kietzmann

1999

Veterinary Dermatology

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“…Based on the geochemistry data obtained, it can be suggested that the superior performance of these clays may be a result of the absence of large mineral complexes and the abundance of exchangeable, charged elements including calcium, iron, magnesium and aluminum, able to modulate cellular processes in favor of wound repair. Indeed, many reports have suggested the beneficial effects of such trace element supplementation on various stages of the dermal wound healing process, especially iron [ 59 , 60 ]. However, the distinct absence of elements in Clay B (Kaolinite) implies that in leachate form, there would be very little bioactivity exhibited.…”

Section: Discussionmentioning

confidence: 99%

A New Look at the Purported Health Benefits of Commercial and Natural Clays

et al. 2021

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Clays attributed to have medicinal properties have been used since prehistoric times and are still used today as complementary medicines, which has given rise to unregulated “bioceutical” clays to treat skin conditions. Recently, clays with antibacterial characteristics have been proposed as alternatives to antibiotics, potentially overcoming modern day antibiotic resistance. Clays with suggested antibacterial properties were examined to establish their effects on common wound-infecting bacteria. Geochemical, microscopical, and toxicological characterization of clay particulates, their suspensions and filtered leachates was performed on THP-1 and HaCaT cell lines. Cytoskeletal toxicity, cell proliferation/viability (MTT assays), and migration (scratch wounds) were further evaluated. Clays were assayed for antibacterial efficacy using minimum inhibitory concentration assays. All clays possessed a mineral content with antibacterial potential; however, clay leachates contained insufficient ions to have any antibacterial effects. All clay leachates displayed toxicity towards THP-1 monocytes, while clay suspensions showed less toxicity, suggesting immunogenicity. Reduced clay cytotoxicity on HaCaTs was shown, as many leachates stimulated wound-healing responses. The “Green” clay exhibited antibacterial effects and only in suspension, which was lost upon neutralization. pH and its interaction with clay particle surface charge is more significant than previously understood to emphasize dangers of unregulated marketing and unsubstantiated bioceutical claims.

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“…Zinc is another transitional metallic element which is highly related to wound healing process. Zinc is mainly as essential component of many enzymes, which regulate the biochemical reactions during the wound healing process [82,83]. Zinc was found to be an essential cofactor of carbonic anhydrase, the first metalloenzyme discovered in 1940s [84].…”

Section: Skin Wound Healingmentioning

confidence: 99%

Conducting polymer based materials for on-skin applications

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Trace Elements in Normal and Impaired Wound Healing

Cited by 5 publications

References 57 publications

Improvement and retardation of wound healing: effects of pharmacological agents in laboratory animal studies

Improvement and retardation of wound healing: effects of pharmacological agents in laboratory animal studies

A New Look at the Purported Health Benefits of Commercial and Natural Clays

Conducting polymer based materials for on-skin applications

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