Trace elements profile is associated with insulin resistance syndrome and oxidative damage in thyroid disorders: Manganese and selenium interest in Algerian participants with dysthyroidism

To expand our understanding of the roles of thyroid hormones on female reproduction, we induced hypo- and hyper-T rat models to investigate the roles of thyroid hormones on estrous cyclicity, as well as the antioxidative status in the ovaries of rats. In the current study, our data show that hypothyroidism (hypo-T) and hyperthyroidism (hyper-T) led to significantly reduced body weights and ovarain weights and delayed vaginal opening day. For hyper-T, thyroxine (T4), tri-iodothyronine (T3), progesterone (P4) and follicle-stimulating hormone (FSH) were significantly increased, while estradiol (E2) and luteinizing hormone (LH) were significantly decreased. For hypo-T rats, serum levels of total T4 and T3, E2, P4, FSH and LH were significantly increased, while concentrations of E2 and LH were significantly decreased. For ovary morphology, the numbers of secondary and antral follicles were significantly decreased with more atretic antral follicles and less corpora lutea in both hyper- and hypo-T groups. Both hyper-T and hypo-T treatment significantly decreased the expressions of thyroid hormone receptor α1 in the ovary. Hypo-T significantly reduced nitric oxide (NO), total NO synthase (tNOS), inducible NOS and constitutive NOS activities, but hyper-T increased them. For antioxidative parameters, hypo-T and hyper-T treatment significantly increased malondialdehyde (MDA) contents. The activities of both glutathione peroxidase (GSH-Px) and catalase (CAT) significantly decreased in the hypo-T group but increased in the hyper-T group. Total superoxide dismutase (T-SOD) activity was significantly increased in the hyper-T group. In summary, thyroid hormones alter estrous cyclicity and antioxidative status in the ovary of the rat may act through the NOS signaling pathway.

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“…; Maouche et al . ). In women, a disordered hypothalamic‐pituitary‐thyroid (HPT) axis manifested elevated T3/T4 ratios.…”

Section: Discussionmentioning

confidence: 97%

Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats

Wei

Fedail

Kong

et al. 2017

Animal Science Journal

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“…Neurocognitive and motor impairments observed in konzo, a motor neuron disease associated with cassava cyanogenic exposure in nutritionally challenged African children, may possibly be driven by the combined effects of cyanide toxicity and selenium deficiency (Bumoko et al, 2015). Selenium and a number of other trace elements may also influence goiter development and general thyroid metabolism (Kishosha et al, 2011;Maouche et al, 2015;El-Fadeli et al, 2016;Gashu et al, 2016). Liver function may be compromised in nickel-plating workers (El-Shafei, 2011).…”

Section: Health Outcomesmentioning

confidence: 99%

“…The relationship between many metals and antioxidant enzymes and the role of the oxidative stress and inflammation pathways needs to be further explored (Maouche et al, 2015). Molecular mechanisms of how oxidative stress acts as a driver for organ dysfunction and the impact of antioxidants to mediate the potential toxic effect of various metal exposures will be important research areas to continue to explore (Samir and Aref, 2011).…”

Section: Research Gapsmentioning

confidence: 99%

Environmental Health Research in Africa: Important Progress and Promising Opportunities

Joubert

Mantooth²,

McAllister

2020

Front. Genet.

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The World Health Organization in 2016 estimated that over 20% of the global disease burden and deaths were attributed to modifiable environmental factors. However, data clearly characterizing the impact of environmental exposures and health endpoints in African populations is limited. To describe recent progress and identify important research gaps, we reviewed literature on environmental health research in African populations over the last decade, as well as research incorporating both genomic and environmental factors. We queried PubMed for peer-reviewed research articles, reviews, or books examining environmental exposures and health outcomes in human populations in Africa. Searches utilized medical subheading (MeSH) terms for environmental exposure categories listed in the March 2018 US National Report on Human Exposure to Environmental Chemicals, which includes chemicals with worldwide distributions. Our search strategy retrieved 540 relevant publications, with studies evaluating health impacts of ambient air pollution (n=105), indoor air pollution (n = 166), heavy metals (n = 130), pesticides (n = 95), dietary mold (n = 61), indoor mold (n = 9), per-and polyfluoroalkyl substances (PFASs, n = 0), electronic waste (n = 9), environmental phenols (n = 4), flame retardants (n = 8), and phthalates (n = 3), where publications could belong to more than one exposure category. Only 23 publications characterized both environmental and genomic risk factors. Cardiovascular and respiratory health endpoints impacted by air pollution were comparable to observations in other countries. Air pollution exposures unique to Africa and some other resource limited settings were dust and specific occupational exposures. Literature describing harmful health effects of metals, pesticides, and dietary mold represented a context unique to Africa. Studies of exposures to phthalates, PFASs, phenols, and flame retardants were very limited. These results underscore the need for further focus on current and emerging environmental and chemical health risks as well as better integration of genomic and environmental factors in African research studies. Environmental exposures with distinct routes of exposure, unique co-exposures and co-morbidities, combined with the extensive genomic diversity in Africa may lead to the identification of novel mechanisms underlying complex disease and promising potential for translation to global public health.

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“…The activation of immune cells leads to an intracellular increase of their Ca 2+ concentration as a potential consequence of ion misbalance, especially that of biometals [69]. As summarized in Table 1, numerous clinical studies emphasize the increase/depletion or disturbances of biometal ratios in the pathophysiology of metabolic disorders [33, 70, 71]. Bioactive metals such as Mg 2+ , Zn 2+ , Se 2+ , Cu 2+ , and Mn 2+ are collectively considered as antioxidant trace elements [70, 72].…”

Section: Biometals In Metabolic Disordersmentioning

confidence: 99%

“…As summarized in Table 1, numerous clinical studies emphasize the increase/depletion or disturbances of biometal ratios in the pathophysiology of metabolic disorders [33, 70, 71]. Bioactive metals such as Mg 2+ , Zn 2+ , Se 2+ , Cu 2+ , and Mn 2+ are collectively considered as antioxidant trace elements [70, 72]. They act as cofactors for antioxidant metalloenzymes [72, 73]: Cu 2+ and Zn 2+ have been identified as cofactors of cytoplasmic superoxide dismutase (Cu-Zn-SOD) [31] and Mn 2+ as a cofactor of mitochondrial SOD (Mn-SOD) [30].…”

Section: Biometals In Metabolic Disordersmentioning

confidence: 99%

The Central Role of Biometals Maintains Oxidative Balance in the Context of Metabolic and Neurodegenerative Disorders

Pokusa

Trančiková

2017

Oxidative Medicine and Cellular Longevity

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Traditionally, oxidative stress as a biological aspect is defined as an imbalance between the free radical generation and antioxidant capacity of living systems. The intracellular imbalance of ions, disturbance in membrane dynamics, hypoxic conditions, and dysregulation of gene expression are all molecular pathogenic mechanisms closely associated with oxidative stress and underpin systemic changes in the body. These also include aspects such as chronic immune system activation, the impairment of cellular structure renewal, and alterations in the character of the endocrine secretion of diverse tissues. All of these mentioned features are crucial for the correct function of the various tissue types in the body. In the present review, we summarize current knowledge about the common roots of metabolic and neurodegenerative disorders induced by oxidative stress. We discuss these common roots with regard to the way that (1) the respective metal ions are involved in the maintenance of oxidative balance and (2) the metabolic and signaling disturbances of the most important biometals, such as Mg2+, Zn2+, Se2+, Fe2+, or Cu2+, can be considered as the central connection point between the pathogenesis of both types of disorders and oxidative stress.

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Trace elements profile is associated with insulin resistance syndrome and oxidative damage in thyroid disorders: Manganese and selenium interest in Algerian participants with dysthyroidism

Cited by 23 publications

References 65 publications

Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats

Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats

Environmental Health Research in Africa: Important Progress and Promising Opportunities

The Central Role of Biometals Maintains Oxidative Balance in the Context of Metabolic and Neurodegenerative Disorders

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