2012
DOI: 10.1152/jn.00692.2011
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Trace fear conditioning enhances synaptic and intrinsic plasticity in rat hippocampus

Abstract: Experience-dependent synaptic and intrinsic plasticity are thought to be important substrates for learning-related changes in behavior. The present study combined trace fear conditioning with both extracellular and intracellular hippocampal recordings to study learning-related synaptic and intrinsic plasticity. Rats received one session of trace fear conditioning, followed by a brief conditioned stimulus (CS) test the next day. To relate behavioral performance with measures of hippocampal CA1 physiology, brain… Show more

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Cited by 53 publications
(62 citation statements)
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“…Previous data demonstrated that the amount of conditioned fear was significantly correlated with the intrinsic excitability of hippocampal CA1 neurons in trace fear conditioned but not pseudoconditioned rats (Song et al, 2012). We therefore examined whether such correlations also exist in mPFC neurons after trace fear conditioning and extinction.…”
Section: Correlations Between Behavioral Performance and Intrinsic Exmentioning
confidence: 89%
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“…Previous data demonstrated that the amount of conditioned fear was significantly correlated with the intrinsic excitability of hippocampal CA1 neurons in trace fear conditioned but not pseudoconditioned rats (Song et al, 2012). We therefore examined whether such correlations also exist in mPFC neurons after trace fear conditioning and extinction.…”
Section: Correlations Between Behavioral Performance and Intrinsic Exmentioning
confidence: 89%
“…Biocytin-filled neurons were fixed in formalin for up to 4 weeks and processed for visualization using a streptavidin Alexa Flour 488 reaction as described previously (Song et al, 2012). Briefly, the slices were incubated in 3% H 2 O 2 /10% methanol for 45 min and washed with PBS, followed by 0.4% Triton X-100/2% BSA for 45 min.…”
Section: Methodsmentioning
confidence: 99%
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