Groundwater is the main water supply in Suzhou City in China. In recent years, heavy metal contamination of urban groundwater sources has become a serious threat to water quality and human health. Groundwater samples from 87 monitoring wells were collected in the study area and analyzed using ICP-MS spectrometry, their major heavy metals concentrations have been analyzed by a series of chemical and statistical indexes for the evaluation of pollution status and dinking suitability. We found that heavy metals are evenly distributed in the groundwater source, 10% of the samples were of excellent quality and 75% were deemed good; however, 70% of the samples exceeded the allowed Mn content. In 62% of the samples, the carcinogenic risk of As exceeded the recommended levels. Based on the non-carcinogenic health risk values, the metals could be ordered as follows: Mn>Fe>Pb>Cu> As>Zn. Mn accounted for 71% of health risk, and the total health risk was mostly due to excess As. Therefore, the levels of As, Mn, and other heavy metal elements in this region warrant urgent regulatory strategies and methods to reduce the Mn concentration should be continuously investigated.