Tracers for Sympathetic Cardiac Neurotransmission Imaging

Thackeray, James T.; DaSilva, Jean N.; Elsinga, Philip H.

doi:10.1007/978-3-662-45074-1_5

Cited by 2 publications

(5 citation statements)

References 76 publications

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“…Currently, several norepinephrine 11 C-labelled analogues are available and under investigation. [ 11 C]meta-Hydroxyephedrine ([ 11 C]mHED, Figure 1 ) is one of them and is the most widely used PET radiotracer for imaging the presynaptic function of the sympathetic nervous system [ 4 , 6 , 13 ]. [ 11 C]mHED is rapidly transported into sympathetic neurons by the norepinephrine transporters by uptake-1 and stored in vesicles.…”

Section: Positron Emission Tomography (Pet) Radiotracersmentioning

confidence: 99%

“…Hydroxyephedrine is synthesized by N-methylation of metaraminol which is a synthetic false neurotransmitter of norepinephrine. 1) is structurally identical to the endogenous neurotransmitter and is the second most common radiopharmaceutical for imaging of the sympathetic nervous system using PET [4,17]. It can be synthesised from norepinephrine by direct N-methylation reporting high radiochemical purity and yield and high specific activity.…”

Section: C-labeled Radiotracersmentioning

confidence: 99%

“…The parasympathetic arm of the heart nervous system primarily uses acetylcholine (ACh) and alternatively peptides as the physiological neurotransmitters. N -[ 11 C]- methylquinuclidinyl benzilate ([ 11 C]-MQNB) has been the tracer with the highest affinity towards muscarinic acetylcholine receptors and is considered the best representative of radiopharmaceuticals assessing the parasympathetic arm of the cardiac autonomous nervous system [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…These radiotracers can be categorized into three main categories, the labelled neurotransmitters such as [ 18 F] dopamine and [ 11 C] epinephrine, the substrate analogues such as [ 123 I]-MIBG, [ 11 C]-mHED and [ 11 C]-phenylephrine and uptake-1 inhibitors such as [ 11 C]-methylreboxetine [ 4 ]. Each one of the aforementioned radiotracers exhibits unique characteristics, giving different information on the function of the cardiac nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac Autonomic Nervous System and Ventricular Arrhythmias: The Role of Radionuclide Molecular Imaging

Fesas¹,

Giannoula

Vrachimis

et al. 2021

Diagnostics

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Widely established compared to myocardial perfusion imaging, cardiac autonomous nervous system (CANS) assessment by radiopharmaceutical means is of potential use especially to arrhythmogenic diseases not correlated with anatomic or functional alterations revealed by classical imaging techniques. Molecular imaging of both pre- and postsynaptic functions of the autonomous nervous system is currently feasible, since single photon emission tomography (SPECT) and positron emission tomography (PET) have the ability to reveal the insights of molecular pathophysiology depicting both sympathetic and parasympathetic imbalance in discrete heart pathologies. This review provides not only a brief presentation of radiopharmaceuticals used for non-invasive CANS imaging in the case of ventricular arrhythmias, but also a current update on ventricular tachycardias, cardiomyopathies, Brugada and Long QT syndrome literature.

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Section: Positron Emission Tomography (Pet) Radiotracersmentioning

confidence: 99%

Section: C-labeled Radiotracersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cardiac Autonomic Nervous System and Ventricular Arrhythmias: The Role of Radionuclide Molecular Imaging

Fesas¹,

Giannoula

Vrachimis

et al. 2021

Diagnostics

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“…As such, there has been exploration of the potential to image signal transduction following adrenergic receptor stimulation. While few of these compounds have yet been evaluated in a clinical setting, the preclinical evidence supports long-term development of multitracer studies, including candidate radiotracers of intracellular signalling, for instance [ 11 C]-rolipram [ 19 – 21 ].…”

Section: Pet Ligands To Imaging the Autonomic Myocardial Functionmentioning

confidence: 99%

PET imaging of the autonomic myocardial function: methods and interpretation

Noordzij

Slart

2015

Clin Transl Imaging

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Cardiac positron emission tomography (PET) is mainly applied in myocardial perfusion and viability detection. Noninvasive imaging of myocardial innervation using PET is a valuable additional methodology in cardiac imaging. Novel methods and different PET ligands have been developed to measure presynaptic and postsynaptic function of the cardiac neuronal system. Obtained PET data can be analysed quantitatively or interpreted qualitatively. Thus far, PET is not a widely used clinical application in autonomic heart imaging; however, due to its technical advantages, the excellent properties of the imaging agents, and the availability of tools for quantification, it deserves a better position in the clinic. From a historical point of view, the focus of PET software packages for image analysis was mainly oncology and neurology driven. Actually, commercially available software for cardiac PET image analysis is still only available for the quantification of myocardial blood flow. Thus far, no commercial software package is available for the interpretation and quantification of PET innervation scans. However, image data quantification and analysis of kinetic data can be performed using adjusted generic tools. This paper gives an overview of different neuronal PET ligands, interpretation and quantification of acquired PET data.

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Tracers for Sympathetic Cardiac Neurotransmission Imaging

Cited by 2 publications

References 76 publications

Cardiac Autonomic Nervous System and Ventricular Arrhythmias: The Role of Radionuclide Molecular Imaging

Cardiac Autonomic Nervous System and Ventricular Arrhythmias: The Role of Radionuclide Molecular Imaging

PET imaging of the autonomic myocardial function: methods and interpretation

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