Tracheal chondrosarcoma: A case report

Farrell, Michael; Gluckman, Jack L.; Biddinger, Paul

doi:10.1002/(sici)1097-0347(199809)20:6<568::aid-hed13>3.0.co;2-d

Cited by 17 publications

(17 citation statements)

References 13 publications

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“…Chondrosarcoma occurs more frequently in adults between the sixth and ninth decades of life, with a median age of 64 years and a range from 32 to 87 years at diagnosis. For low-grade tumours, the male to female ratio is 8:1, with no particular gender predilection for high-grade tumours [6]. These malignancies have a very slow growth, presenting as a bulky tumour and obstructing >75% of the tracheal lumen.…”

Section: Discussionmentioning

confidence: 99%

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Tracheal chondrosarcoma

et al. 2010

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Tracheal chondrosarcoma are rare diseases, with only 15 cases previously described in the literature between 1959 and 2008. Here we present a rare case of tracheal chondrosarcoma and a review of the literature. Our patient, a 72-year-old man, had progressive throat pain for 2 years before diagnosis. Clinical and imaging investigation revealed a giant tracheal mass that was partially debulked by laser for symptomatic relief. Histologically, the mass was characterized as a low-grade tracheal chondrosarcoma. The patient underwent external-beam radiotherapy (EBRT) and received 60 Gy. At the time this report was written, 7 years after the end of the treatment, the patient was alive and asymptomatic without evidence of locoregional disease. This case and some described in the literature demonstrate the value of EBRT as a single treatment modality in achieving local control. More experience is required to establish the definitive role of radiotherapy in low-grade tracheal chondrosarcoma.

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Section: Discussionmentioning

confidence: 99%

“…These malignancies have a very slow growth, presenting as a bulky tumour and obstructing >75% of the tracheal lumen. The defi nitive diagnosis is commonly delayed -usually 17.4 (1-72) months after symptoms began [6]. Histology of the low-grade chondrosarcoma and chondroma is diffi cult to determine.…”

Section: Discussionmentioning

confidence: 99%

Tracheal chondrosarcoma

et al. 2010

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“…Chondromas have predominantly intraluminal growth, whereas chondrosarcomas are more likely to cause thickening of the tracheal wall, with extraluminal extension. 5 Mediastinal lymphadenopathy was not noted in most of the cases, probably because there was no metastasis. Bronchoscopy is important to obtain a biopsy specimen and decide the treatment strategy.…”

Section: Discussionmentioning

confidence: 94%

“…Thus, only 14 cases of chondrosarcoma have been documented in the literature. [3][4][5][6] Those 14 and the present case are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 95%

Tracheal chondrosarcoma

Umezu

Tamura

Kobayashi

et al. 2008

Gen Thorac Cardiovasc Surg

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Tracheal chondrosarcomas are rare, with only 14 cases previously documented. We report a case of chondrosarcoma of the trachea and review other published cases. Our patient was a 34-year-old man who began to feel shortness of breath 8 months after initial hemoptysis. Transverse and coronal computed tomography demonstrated a tumor that was obstructing nearly 80% of the tracheal lumen at the thoracic inlet. A bronchoscopic biopsy specimen led to an initial diagnosis of chondroma. Five tracheal rings from the third to the seventh including the tumor were completely resected, and an end-to-end anastomosis was performed. The histological diagnosis of the surgical specimen showed it to be a chondrosarcoma. The patient was alive without recurrence at 6 years 4 months after surgery. Because recurrence after incomplete resection and malignant transformation can occur with chondromas, radical resection of the trachea is recommended for all cartilaginous tumors of the trachea.

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“…Patients with tracheal chondrosarcoma are often asymptomatic until the tumor occludes greater than 75% of the tracheal lumen [14, 17]. The most commonly reported symptoms include dyspnea (the most common symptom, occurring in 100% of these patients), nonproductive cough, and wheeze.…”

Section: Discussionmentioning

confidence: 99%

Tracheal Chondrosarcoma: Systematic Review of Tumor Characteristics, Diagnosis, and Treatment Outcomes with Case Report

Kutzner

Park

Zaheer

et al. 2017

Case Reports in Oncological Medicine

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To our knowledge this is the first systematic review of tracheal chondrosarcoma treatment outcomes. Management insights are thoroughly discussed. Men constitute 93.8% of cases, and most of these occur in the distal trachea. The most common symptom, dyspnea, occurs in virtually all patients. Extratracheal extension had occurred in 78.6% of patients. Definitive treatment with tracheal resection showed no recurrences in 10 patients with mean follow-up of 3.1 years. Adjuvant radiotherapy may be utilized for improving local control when open complete resection cannot be performed, but only after endoscopic excision of gross tumor.

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Tracheal chondrosarcoma: A case report

Cited by 17 publications

References 13 publications

Tracheal chondrosarcoma

Tracheal chondrosarcoma

Tracheal chondrosarcoma

Tracheal Chondrosarcoma: Systematic Review of Tumor Characteristics, Diagnosis, and Treatment Outcomes with Case Report

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