Tracheal granuloma pyogenicum with erlotinib treatment for lung cancer

Local Bevacizumab Treatment of Juvenile‐Onset Respiratory Papillomatosis Might Induce Multiple Tracheal Pyogenic Granulomas

“…As of 2016, only 16 cases of solitary pyogenic granuloma of the trachea had been reported 5 . In addition, only one case of multiple pyogenic granulomas, remarkably similar to our case, was reported previously 4 . However, in that case, the granulomas developed in an adult patient after treating lung cancer intravenously with the epidermal growth factor receptor inhibitor, erlotinib 4 …”

“…Moreover, we speculated that the jet ventilation might have facilitated the spreading of bevacizumab into the trachea and tracheal epithelium. Due to the lack of another explanation for the presence of a pyogenic granuloma in the trachea of our patient, we made the diagnosis after ruling out other potential causes and based on similarities to a previously published case report of an adult patient 4 …”

“…It might cause a pertinacious cough, and it could potentially obstruct breathing, when localized in trachea. Moreover, pyogenic granuloma was also reported to cause hemoptysis 4,5 . As of 2016, only 16 cases of solitary pyogenic granuloma of the trachea had been reported 5 .…”

Tracheal Lobular Capillary Haemangioma: A Rare Benign Cause of Recurrent Haemoptysis

“…Circulatory assistance with extracorporeal membrane oxygenation was employed as a precautionary measure when debulking a large LCH in a 23-year-old pregnant female in the report by Prakash et al [ 10 ]. Putora et al propose this lesion occurring as a consequence of erlotinib chemotherapy in a 64-year-old patient with squamous cell lung cancer; interestingly, complete resolution of the LCH was noted on discontinuation of erlotinib and no invasive intervention was necessary [ 18 ].…”

Subglottic Lobular Capillary Hemangioma: A Case Report

“…LCH in the gastrointestinal tract has also been reported [5]. LCH lesions are very rare in the airway, with only a few cases reported to date [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] and subglottic LCH is unique. Here, we present the case of an 11-year-old boy who presented with a subglottic LCH, posing both a diagnostic and therapeutic challenge.…”