Tracheal reconstruction using alcohol-stored homologous cartilage and autologous cartilage in the rabbit model

Characterization of a biologically derived rabbit tracheal scaffold

“…For tracheal defects exceeding one‐third of the trachea or recurrent disease no alternative treatment exist. Experimental studies using autologous and alcohol‐stored homologous cartilage for tracheal reconstruction in a rabbit model have shown poor tissue integration and cartilage formation . Artificial prostheses are associated with material migration, infection, and contamination .…”

“…Experimental studies using autologous and alcohol-stored homologous cartilage for tracheal reconstruction in a rabbit model have shown poor tissue integration and cartilage formation. 18 Artificial prostheses are associated with material migration, infection, and contamination. 19 Cryopreserved tracheal allografts in growing rabbits have shown a patent airways over a period of 3 months but no growth of the implants.…”

Comparison of costal cartilage and Dacron® graft in laryngotracheal reconstruction: an experimental study

“…[22] They established that autografts were superior in that they contained considerably higher percentage of viable cells (95%/30%) with less resorption, fibrosis and necrosis. All autografts, but only 65% of the homografts were epithelized.…”

Intracordal Injections With Allogenic Cartilage in a Canine Paralyzed Vocal Fold Model: Long-Term Results

“…4, 2012 resistant to rejection, the chronic resorption of allogenic cartilage has been reported. 10,11 Host response to allogenic cartilage graft was induced by MHC class II antigen presented in the perichondrium. 17 MHC class II antigen expression was found on cells of the superficial area of the perichondrium of the cartilage.…”

“…9 Despite immunological privilege because of the matrix, chronic resorption of homologous allogenic cartilage has been reported. 10,11 Several methods including irradiation, chemical treatments (alcohol, formaldehyde, Merthiolate, and detergent), and cryopreservation can lead to a decrease in antigen expression. [12][13][14][15] For example, irradiated allogenic cartilage has been a good candidate material for rhinoplasty.…”