Tracheal Replacement with Heavy Marlex Mesh

Estudo Da Reação Cicatricial E Da Resposta À Ventilação Mecânica Intraoperatória Em Transplantes Segmentares De Traquéia - Autólogos E Homólogos - Em Coelhos

“…Observou-se que tanto o transplante autólogo como o homólogo de segmentos circunferenciais de traquéia apresentaram-se factíveis experimentalmente em coelhos com complicações e viabilidade similares. Conforme evidenciado em outros estudos, [27][28][29][30][31] a ocorrência de rejeição, infecção, estenose, fístula e outras alterações cicatriciais podem ocorrer em ambos os tipos de enxertos. O maior tempo de sobrevida observado nos animais do Grupo I evidencia maior aceitação de enxerto autólogo em relação ao homólogo.…”

Prosthetic reconstruction of the trachea: A historical perspective

“…There was a proliferation of literature and animal studies in this field during the 1950s and 1960s[32-36]. This culminated in a better understanding of an ideal prosthesis in that the graft should be airtight, have adequate consistency, be well accepted by the host, cause minimal inflammatory reaction, be impervious to fibroblastic and bacterial invasion into the lumen but ideally allow ingrowth of respiratory epithelium along the lumen[15,33,35]. The decision of material to trial was often dependent upon industrial and commercial advances and availability, ranging from steel wire, tantalum, marlex, PTFE, dacron and teflon[2,29-36].…”

“…In addition, it was concluded that an entirely satisfactory tracheal graft will never be available[31,35]. The silicone airway is at least as satisfactory as any prosthesis yet fashioned for tracheal replacement and any alternative must be wholly dependable with minimal morbidity and mortality[31].…”

Polymeric implant materials for the reconstruction of tracheal and pharyngeal mucosal defects in head and neck surgery

“…In the 60ies and 70ies further materials were tested for tracheal reconstruction e.g. Marlex networks (polyethylene/polypropylene networks) [ 54 ], silicon rubber [ 55 ] and Marlex networks covered with cartilage and/or tracheal mucosa [ 56 ], [ 57 ]. These new materials also did not fulfill the comprehensive requirements for tracheal reconstruction regarding mechanical strength and adequate flexibility to avoid vascular arrosion induced by mechanical irritation.…”

“…These new materials also did not fulfill the comprehensive requirements for tracheal reconstruction regarding mechanical strength and adequate flexibility to avoid vascular arrosion induced by mechanical irritation. These materials lacked biocompatibility, an air- and liquid tight integration of the implant materials into the adjacent body tissues, an adequate stability against bacterial invasion and, especially, the epithelialization of the implant with a functional tracheal epithelium [ 54 ], [ 55 ], [ 56 ], [ 57 ].…”